CSPG4

CSPG4
識別號
别名	CSPG4；, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4, CSPG4A
外部ID	OMIM：601172 MGI：2153093 HomoloGene：20445 GeneCards：CSPG4
基因位置（人类）
染色体	15號染色體
终止	75,712,848 bp
基因位置（小鼠）
染色体	小鼠9号染色体
终止	56,807,154 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• signal transducer activity; • protein kinase binding;
細胞組分	• integral component of membrane; • cell projection; • 膜; • 粘着斑; • 细胞膜; • integral component of plasma membrane; • 細胞外區域; • cell surface; • lysosomal lumen; • apical plasma membrane; • Golgi lumen; • 外排體; • lamellipodium membrane; • 细胞外间质; • collagen-containing extracellular matrix;
生物學過程	• glycosaminoglycan metabolic process; • 细胞分化; • intracellular signal transduction; • transmembrane receptor protein tyrosine kinase signaling pathway; • chondroitin sulfate biosynthetic process; • multicellular organism development; • 血管新生; • positive regulation of peptidyl-tyrosine phosphorylation; • chondroitin sulfate catabolic process; • dermatan sulfate biosynthetic process; • 細胞增殖; • tissue remodeling; • 訊息傳遞; • glial cell migration;
	Sources:Amigo / QuickGO
直系同源
	1464
	121021
	ENSG00000173546
	ENSMUSG00000032911
	Q6UVK1
	Q8VHY0
	NM_001897
	NM_139001
	NP_001888
	NP_620570
	維基數據
檢視/編輯人類	檢視/編輯小鼠

CSPG4（Chondroitin sulfate proteoglycan 4，“硫酸軟骨素蛋白聚醣4”，也称为“黑色素瘤相关硫酸軟骨素蛋白聚醣”，melanoma-associated chondroitin sulfate proteoglycan，MCSP，“神经元-胶质抗原2”，neuron-glial antigen 2，NG2）是一种细胞表面蛋白质，硫酸軟骨素蛋白聚醣的一员，由人类基因 CSPG4 编码，是少突先驅膠質細胞（OPC）的主要标志物^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000173546 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032911 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishiyama A, Dahlin KJ, Prince JT, Johnstone SR, Stallcup WB. The primary structure of NG2, a novel membrane-spanning proteoglycan. The Journal of Cell Biology. July 1991, 114 (2): 359–71. PMC 2289079 . PMID 1906475. doi:10.1083/jcb.114.2.359.

外部链接

Human CSPG4 genome location and CSPG4 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

这是一篇分子與細胞生物學（分子細胞生物學）小作品。您可以通过编辑或修订扩充其内容。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000173546 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000032911 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Nishiyama A, Dahlin KJ, Prince JT, Johnstone SR, Stallcup WB. The primary structure of NG2, a novel membrane-spanning proteoglycan. The Journal of Cell Biology. July 1991, 114 (2): 359–71. PMC 2289079 . PMID 1906475. doi:10.1083/jcb.114.2.359.

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