Volume 13, Number 2—February 2007
Dispatch
Ertapenem Resistance of Escherichia coli
Marie-Frédérique Lartigue*, Laurent Poirel*, Claire Poyart†, Hélène Réglier-Poupet†, and Patrice Nordmann*
Table
MICs of β-lactam antimicrobial drugs for Escherichia coli CO, transconjugants pCO-1 and pCO-2, and reference strain E. coli J53*
| β-lactam | MIC (mg/L) | |||
|---|---|---|---|---|
| E. coli CO | Transconjugant pCO-1 (CTX-M-2) | Transconjugant pCO-2 (OXA-10, TEM-1) | E. coli J53 | |
| Amoxicillin | >256 | >256 | >256 | 2 |
| Amoxicillin + CLA | >256 | 8 | 64 | 2 |
| Ticarcillin | >256 | >256 | >256 | 2 |
| Ticarcillin + CLA | >256 | 32 | 128 | 2 |
| Piperacillin | >256 | >256 | 64 | 1 |
| Piperacillin + TZB | 256 | 2 | 32 | 1 |
| Cephalotin | >256 | >256 | 4 | 4 |
| Cefoxitin | 256 | 4 | 4 | 4 |
| Ceftazidime | 64 | 4 | 0.06 | 0.06 |
| Ceftazidime + CLA | 1 | 0.125 | 0.06 | 0.06 |
| Cefotaxime | >256 | 64 | 0.06 | 0.06 |
| Cefotaxime + CLA | 128 | 1 | 0.06 | 0.06 |
| Cefepime | >256 | 16 | 0.06 | 0.06 |
| Moxalactam | 128 | 0.06 | 0.06 | 0.06 |
| Aztreonam | >256 | 32 | 0.06 | 0.06 |
| Imipenem | 8 | 0.25 | 0.25 | 0.25 |
| Meropenem | 8 | 0.06 | 0.06 | 0.06 |
| Ertapenem | >256 | 0.03 | 0.03 | 0.03 |
*CLA, clavulanic acid at a fixed concentration of 2 mg/L; TZB, tazobactam at a fixed concentration of 4 mg/L..
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