sonidegib (Q22075856)

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chemical compound

LDE225
erismodegib (deleted INN)
LDE-225
NVP-LDE225
Odomzo®
NVP-LDE 225
LDE 225
Erismodegib
N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
Sonidegib

Language	Label	Description	Also known as
English	sonidegib	chemical compound	LDE225 erismodegib (deleted INN) LDE-225 NVP-LDE225 Odomzo® NVP-LDE 225 LDE 225 Erismodegib N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide Sonidegib

Statements

type of chemical entity

0 references

chemical compound

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chemical structure

Sonidegib.svg
512 × 216; 6 KB

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485.192626 dalton

1 reference

language of work or name

Erismodegib (English)

3 October 2016

chemical formula

C₂₆H₂₆F₃N₃O₃

1 reference

language of work or name

Erismodegib (English)

20 November 2016

canonical SMILES

CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F

1 reference

language of work or name

Erismodegib (English)

20 November 2016

isomeric SMILES

C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F

1 reference

language of work or name

Erismodegib (English)

20 November 2016

active ingredient in

1 reference

14 February 2018

World Health Organisation international non-proprietary name

sonidegib (English)

2 references

language of work or name

sonidegib (English)

3 October 2016

Recommended INN: List 69

publication date

2013

medical condition treated

basal-cell carcinoma

1 reference

Drug Indications Extracted from FAERS

2 October 2018

physically interacts with

smoothened, frizzled class receptor

subject has role

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

smoothened, frizzled class receptor

subject has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2105737

legal status (medicine)

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

LiverTox likelihood score

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Sonidegib

1 June 2017

Commons category

Sonidegib

0 references

Identifiers

InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+

1 reference

language of work or name

Erismodegib (English)

20 November 2016

VZZJRYRQSPEMTK-CALCHBBNSA-N

2 references

language of work or name

Erismodegib (English)

20 November 2016

ChEBI release 2020-09-01

CAS Registry Number

2 references

Global Substance Registration System

language of work or name

sonidegib (English)

20 November 2016

VZZJRYRQSPEMTK-CALCHBBNSA-N

CAS Common Chemistry

9 April 2021

https://commonchemistry.cas.org/detail?cas_rn=956697-53-3

1 reference

language of work or name

Sonidegib (English)

20 November 2016

2 references

language of work or name

Erismodegib (English)

20 November 2016

matched by identifier from

VZZJRYRQSPEMTK-CALCHBBNSA-N

Reaxys registry number

19431762

1 reference

language of work or name

sonidegib (English)

3 October 2016

mapping relation type

2 references

language of work or name

sonidegib (English)

3 October 2016

matched by identifier from

International Chemical Identifier

InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+

1 reference

language of work or name

ERISMODEGIB (English)

20 November 2016

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

VZZJRYRQSPEMTK-CALCHBBNSA-N

UniChem compound ID

1 reference

DSSTox substance ID

DTXSID501009335

1 reference

matched by identifier from

VZZJRYRQSPEMTK-CALCHBBNSA-N

DSSTOX compound identifier

DTXCID101436164

0 references

0 references

0 references

World Health Organisation international non-proprietary name numeric ID

1 reference

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9394

Guide to Pharmacology Ligand ID

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

sonidegib (English)

20 November 2016

1 reference

Global Substance Registration System

language of work or name

sonidegib (English)

20 November 2016

1 reference

matched by identifier from

VZZJRYRQSPEMTK-CALCHBBNSA-N

2 references

Global Substance Registration System

language of work or name

sonidegib (English)

20 November 2016

matched by identifier from

VZZJRYRQSPEMTK-CALCHBBNSA-N

MedlinePlus drug identifier

0 references

1 reference

Global Substance Registration System

language of work or name

sonidegib (English)

20 November 2016

Probes And Drugs ID

0 references

1 reference

1 reference

language of work or name

sonidegib (English)

3 October 2016

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Microsoft Academic ID

0 references

1 reference

Global Substance Registration System

language of work or name

sonidegib (English)

20 November 2016

WikiProjectMed ID

0 references

Sitelinks

Wikipedia(5 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Sonidegib

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