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Obesity in childhood and vascular changes in adulthood: insights into the Cardiovascular Risk in Young Finns Study

International Journal of Obesity volume 29, pages S101–S104 (2005)Cite this article

Abstract

AIMS:

Exposure to risk factors in childhood may have long-term influences on vascular structure and function. This paper reviews recent findings from the Cardiovascular Risk in Young Finns Study looking at the relationships between risk factors identified in childhood, including obesity, and arterial structure/function assessed in adulthood.

METHODS:

The Young Finns Study is a longitudinal study from childhood to adulthood. The baseline study was carried out in 1980 and included 3.596 children and adolescents aged 3–18 y. Regular follow-up examinations of this cohort have included comprehensive data collection, including obesity indices (body mass index (BMI, kg/m2) and skinfolds in childhood), serum lipoproteins, insulin, glucose, blood pressure, family risk, lifestyle factors, smoking status, alcohol use, physical activity, psychological factors, diet and socioeconomic status. The latest follow-up was carried out in 2001 (N=2283, ages 24–39 y). In addition to the usual protocol, this 21-y follow-up study included ultrasound measurements of carotid artery intima–media thickness (IMT) and carotid artery elasticity.

RESULTS:

In this cohort, BMI measured in youth is significantly associated with BMI measured in adulthood. The correlation coefficient for 21-y tracking between childhood and adulthood BMI is r=0.45 (P<0.0001). In multivariate analysis, childhood LDL-cholesterol, systolic blood pressure, BMI and smoking were all significantly associated with adult IMT. The effects of childhood LDL-cholesterol and systolic blood pressure remained independently associated with carotid IMT when adjusted for the current risk factor values (P<0.01 for both). However, when adulthood BMI was entered into the model, the effect of childhood BMI became nonsignificant. The age- and sex-adjusted multivariate correlates of carotid artery elasticity included childhood skinfold thickness (sum of biceps, triceps and subscabular) and childhood systolic blood pressure. Childhood systolic blood pressure remained borderline significantly (P=0.08) associated with carotid elasticity when the effect of current blood pressure was taken into account. However, the effect of childhood skinfold thickness on carotid artery elasticity became nonsignificant (P=0.16) when adjusted with adult BMI.

CONCLUSIONS:

The data from the Cardiovascular Risk in Young Finns Study suggest that obesity indices measured in youth are significantly associated with increased carotid artery IMT and decreased elasticity in adulthood. These relations are, at least, partly explained by significant tracking of obesity from youth to adulthood. These findings emphasize the importance of maintaining ideal weight from youth to adulthood in cardiovascular risk reduction.

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References

  1. McGill Jr HC, McMahan CA, Herderick EE, Tracy RE, Malcom GT, Zieske AW, Strong JP . Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol 2000; 20: 836–845.

    Article  Google Scholar 

  2. Berenson GS, Srinivasan SR, Bao W, Newman III WP, Tracy RE, Wattigney WA . Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998; 338: 1650–1656.

    Article  CAS  Google Scholar 

  3. Åkerblom HK, Viikari J, Uhari M, Räsänen L, Byckling T, Louhivuori K, Pesonen E, Suoninen P, Pietikäinen M, Lähde PL . Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families’ state of health. Acta Paediatr Scand Suppl 1985; 318: 49–63.

    Article  Google Scholar 

  4. Dahlström S, Viikari J, kerblom HK, Solakivi-Jaakkola T, Uhari M, Dahl M, Lahde PL, Pesonen E, Pietikäinen M, Suoninen P . Atherosclerosis precursors in Finnish children and adolescents. II. Height, weight, body mass index, and skinfolds, and their correlation to metabolic variables. Acta Paediatr Scand Suppl 1985; 318: 65–78.

    Article  Google Scholar 

  5. Åkerblom HK, Viikari J, Raitakari OT, Uhari M . Cardiovascular Risk in Young Finns Study: general outline and recent developments. Ann Med 1999; 31 (Suppl 1): 45–54.

    Article  Google Scholar 

  6. Viikari JS, Niinikoski H, Juonala M, Raitakari OT, Lagstrom H, Kaitosaari T, Ronnemaa T, Simell O . Risk factors for coronary heart disease in children and young adults. Acta Paediatr Suppl 2004; 93: 34–42.

    Article  CAS  Google Scholar 

  7. Juonala M, Viikari JS, Hutri-Kähönen N, Pietikäinen M, Jokinen E, Taittonen L, Marniemi J, Rönnemaa T, Raitakari OT . The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east–west difference. J Intern Med 2004; 255: 457–468.

    Article  CAS  Google Scholar 

  8. Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, Järvisalo MJ, Uhari M, Jokinen E, Rönnemaa T, Åkerblom HK, Viikari JSA . Cardiovascular risk factors in childhood and carotid artery intima–media thickness in adulthood—The Cardiovascular Risk in Young Finns Study. JAMA 2003; 290: 2277–2283.

    Article  CAS  Google Scholar 

  9. Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JSA, Raitakari OT . Risk factors identified in childhood and decreased carotid artery elasticity in adulthood. The Cardiovascular Risk in Young Finns Study. Circulation (in press).

  10. Raitakari OT . Imaging of subclinical atherosclerosis in children and young adults. Ann Med 1999; 31 (Suppl 1): 33–40.

    Article  Google Scholar 

  11. O’Leary DH, Polak JF . Intima–media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002; 90: 18L–21L.

    Article  Google Scholar 

  12. Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM . Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 1998; 32: 570–574.

    Article  CAS  Google Scholar 

  13. Raitakari OT, Porkka KV, Rönnemaa T, Knip M, Uhari M, Åkerblom HK, Viikari JS . The role of insulin in clustering of serum lipids and blood pressure in children and adolescents. The Cardiovascular Risk in Young Finns Study. Diabetologia 1995; 38: 1042–1050.

    Article  CAS  Google Scholar 

  14. Chen W, Bao W, Begum S, Elkasabany A, Srinivasan SR, Berenson GS . Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: the Bogalusa Heart Study. Diabetes 2000; 49: 1042–1048.

    Article  CAS  Google Scholar 

  15. Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH . Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922–1935. N Engl J Med 1992; 327: 1350–1355.

    Article  CAS  Google Scholar 

  16. Gunnell DJ, Frankel SJ, Nanchahal K, Peters TJ, Davey SG . Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort. Am J Clin Nutr 1998; 67: 1111–1118.

    Article  CAS  Google Scholar 

  17. Casey VA, Dwyer JT, Coleman KA, Valadian I . Body mass index from childhood to middle age: a 50-y follow-up. Am J Clin Nutr 1992; 56: 14–18.

    Article  CAS  Google Scholar 

  18. Oren A, Vos LE, Uiterwaal CS, Gorissen WH, Grobbee DE, Bots ML . Change in body mass index from adolescence to young adulthood and increased carotid intima–media thickness at 28 years of age: the Atherosclerosis Risk in Young Adults study. Int J Obes Relat Metab Disord 2003; 27: 1383–1390.

    Article  CAS  Google Scholar 

  19. Mahoney LT, Burns TL, Stanford W, Thompson BH, Witt JD, Rost CA, Lauer RM . Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study. J Am Coll Cardiol 1996; 27: 277–284.

    Article  CAS  Google Scholar 

  20. Power C, Lake JK, Cole TJ . Body mass index and height from childhood to adulthood in the 1958 British born cohort. Am J Clin Nutr 1997; 66: 1094–1101.

    Article  CAS  Google Scholar 

  21. Freedman DS, Dietz WH, Tang R, Mensah GA, Bond MG, Urbina EM, Srinivasan S, Berenson GS . The relation of obesity throughout life to carotid intima–media thickness in adulthood: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2004; 28: 159–166.

    Article  CAS  Google Scholar 

  22. Young JB . Effect of experimental hyperinsulinemia on sympathetic nervous system activity in the rat. Life Sci 1988; 43: 193–200.

    Article  CAS  Google Scholar 

  23. Keaney Jr JF, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ . Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 2003; 23: 434–439.

    Article  CAS  Google Scholar 

  24. Wisse BE . The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 2004; 15: 2792–2800.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Physiology, University of Turku, Finland

    O T Raitakari

  2. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland

    M Juonala

  3. Department of Medicine, University of Turku, Finland

    J S A Viikari

Authors
  1. O T Raitakari
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  2. M Juonala
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  3. J S A Viikari
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Correspondence to O T Raitakari.

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Raitakari, O., Juonala, M. & Viikari, J. Obesity in childhood and vascular changes in adulthood: insights into the Cardiovascular Risk in Young Finns Study. Int J Obes 29 (Suppl 2), S101–S104 (2005). https://doi.org/10.1038/sj.ijo.0803085

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