1
as in weakening
to diminish the physical strength of
an athlete prostrated for weeks by a bout of pneumonia
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2
as in paralyzing
to render powerless, ineffective, or unable to move
the huge increase in gas prices really prostrated the nation's economic engine
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3
as in overcoming
to subject to incapacitating emotional or mental stress
a widow prostrated by crushing grief
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4
as in downing
to strike (someone) so forcefully as to cause a fall
the boxer bragged that he could prostrate any opponent with a single blow
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Merriam-Webster unabridged
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