Search Results (2,779)

Using methods of DFT, we investigated the effect of electron withdrawing and electron donating groups on the relative stability of tentative glycosyl donor reaction intermediates. The calculation shows that by changing the stereoelectronic properties of the protecting group, we can influence the stability of the dioxolenium type of intermediates by up to 10 kcal mol⁻¹, and that by increasing nucleophillicity of the 4-O-Bz group, the dioxolenium intermediate becomes more stable than a triflate–donor pair. We exploited this mechanism to design galactosyl donors with custom protecting groups on O2 and O4, and investigated the outcome of the reaction with cyclohexanol. The reaction showed no change in the product distribution, which suggests that the neighboring group participation takes precedence over remote group participation due to kinetic barriers. Full article

Background/Objectives: Hypoxic-ischemic encephalopathy (HIE) in late preterm and term neonates accounts for neonatal mortality and unfavorable neurodevelopmental outcomes in survivors despite therapeutic hypothermia (TH) for neuroprotection. The circumstances of death in neonates with HIE, including involvement of neonatal palliative care (NPC) specialists and neurodevelopmental follow-up at 18–24 months in survivors, warrant further evaluation. Methods: A retrospective multicenter cohort study including neonates ≥ 35 weeks gestational age with moderate to severe HIE receiving TH, registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2021. Neurodevelopmental follow-up at 18–24 months in survivors was assessed. The groups of survivors and deaths were compared regarding perinatal demographic and HIE data. Prognostic factors leading to redirection of care (ROC) were depicted. Results: A total of 137 neonates were included, with 23 (16.8%) deaths and 114 (83.2%) survivors. All but one death (95.7%) occurred after ROC, with death on a median of 3.5 (2–6) days of life. Severe encephalopathy was indicated by a Sarnat score of 3 on admission, seizures were more frequent, and blood lactate values were higher on postnatal days 1 to 4 in neonates who died. Lactate in worst blood gas analysis (unit-adjusted odds ratio 1.25, 95% CI 1.02–1.54, p = 0.0352) was the only variable independently associated with ROC. NPC specialists were involved in one case. Of 114 survivors, 88 (77.2%) had neurodevelopmental assessments, and 21 (23.9%) of those had unfavorable outcomes (moderate to severe disability). Conclusions: Death in neonates with moderate to severe HIE receiving TH almost exclusively occurred after ROC. Parents thus had to make critical decisions and accompany their neonate at end-of-life within the first week of life. Involvement of NPC specialists is encouraged in ROC so that there is continuity of care for the families whether the neonate survives or not. Full article

The aggregation of ride-sharing platforms has forced traditional ride-sharing platforms to decide whether to join or leave these emerging platforms. This study presents a stylized model analyzing the demand, supply, and profit of two self-operated platforms, C2C platforms (such as DiDi and Uber) and B2C platforms, considering aggregation platform awareness and commissions. The study investigates the conditions under which the self-operated platforms should employ the entry strategy based on the optimization method and Cournot game theory, as well as exploring the reasons why self-operated platforms choose to withdraw after joining. The results show that in order to avoid competition, B2C platforms adopt an entry strategy, while C2C platforms adopt a non-entry strategy. Only during the off-peak period, when the awareness of the aggregation platform is very high and the level of competition between the two types of platforms is very intense, will both types of platforms adopt an entry strategy, but C2C platforms may experience a significant loss of market share, leading to a decline in social welfare. Furthermore, even if the self-operated platform chooses to withdraw, social welfare will still increase if the two self-operated platforms adopt the best strategy. The study contributes to sustainable development by promoting efficient resource allocation, reducing redundant competition, and improving overall market efficiency, thereby fostering a more sustainable urban transportation system. Full article

This study presents a comprehensive investigation into the synthesis and characterization of TiO₂ coatings on glass substrates, focusing on the development of superhydrophilic, self-cleaning titania coatings using the hydrosol approach. Stringent cleaning protocols were accurately followed to ensure the pristine condition of glass surfaces prior to deposition. Various organic precursor solutions were precisely prepared and applied to the glass substrate via dip-coating, followed by subsequent thermal treatment. A range of characterization techniques, including Raman spectroscopy, UV/Vis spectroscopy, scanning and atomic force microscopy, X-ray photoelectron spectroscopy, and contact angle measurements, were employed to assess the properties of the coatings. The results revealed that the samples were influenced by precursor concentration and withdrawal rate, with slow speed leading to minimal alteration of transmittance. The coatings show superhydrophilic properties, as evidenced by contact angle values below 3 degrees for the thinnest films. Their thickness is approximately 13 nm with very low roughness, indicative of a smooth and uniform surface. Optimization of the deposition conditions permits the fabrication of uniform and transparent TiO₂ coatings on glass substrates, offering promising opportunities for the practical use of photoinduced self-cleaning surfaces in real-life applications. Finally, a cost analysis of scaling up the coating and mirror fabrication processes confirmed the economic feasibility of this approach for concentrated solar power (CSP) applications. Full article

Background: Considering the increasing consumption of soft drinks and their adverse health effects, identifying addiction to these drinks in the population is significant. Accordingly, this study aimed to evaluate the reliability and validity of the Turkish version of the Soft Drink Addiction Scale. Methods: For this purpose, we included 669 participants and distributed them homogeneously for exploratory and confirmatory factor analyses. To assess the psychometric properties of the scale, we used the Soft Drink Addiction Scale, the Beverage Intake Questionnaire-15, and a questionnaire that included questions assessing self-efficacy regarding soft drinks and attitudes toward alternatives. Results: The mean age of 669 participants was 34.05 ± 9.26 years. A total of 93.72% were female and 6.28% were male. The scale’s Cronbach’s alpha coefficient was 0.942. An exploratory factor analysis revealed the following three-factor structure: withdrawal syndrome symptoms, persistent desire, and decrease in social and recreational activities, which explained 29.1%, 16%, and 16.9% of the total variance, respectively. A confirmatory factor analysis also confirmed this construct. Moreover, soft drink addiction was associated with self-efficacy and total calories from beverages questioned in the beverage consumption questionnaire. Conclusions: In conclusion, the Turkish version of the Soft Drink Addiction Scale is a reliable and valid tool. Full article

Background: High-volume online hemodiafiltration (OL-HDF) has proven to be the most efficient dialysis modality and to offer better clinical outcomes in patients on hemodialysis. Longer and more frequent dialysis sessions have demonstrated clinical and survival benefits. Methods: A single-center observational study of the first one hundred patients on nocturnal every-other-day OL-HDF was conducted with the aim of reporting the experience with this treatment schedule and evaluating analytical and clinical outcomes as well as the patient and technique survival. Results: Nocturnal OL-HDF on alternate days was highly accepted, with no adverse symptoms, good clinical tolerance, and maintained active work in 62%. Kt, and the convective volume increased from 67.6 ± 12 L to 105.4 ± 11.7 L, and from 27.1 ± 4.6 L to 48.1 ± 6.4 L, respectively, from the baseline to 24 months. An improved calcium–phosphate balance and blood pressure control were observed, as the use of phosphate binders and antihypertensive medications decreased from 76.7% to 3.3% and from 56.7% to 28.3%, respectively. Furthermore, 58.3% of patients required phosphate supplementation in the dialysis fluid to prevent intradialytic hypophosphatemia. Additionally, doses of iron and erythropoiesis-stimulating agents were reduced. The global patient survival was 94% at the end of the follow-up. It was higher in those on the transplant waiting list, with 98.1% survival compared to 84.6% in non-wait-listed patients at 24 months. The main reason for treatment discontinuation was kidney transplantation, accounting for 78.4% of the 88 withdrawals, while death was the leading cause of discontinuation in non-listed patients (41.6%). Conclusions: Nocturnal every-other-day OL-HDF is a well-tolerated dialysis regimen that offers significant clinical benefits, which may positively impact morbidity and mortality. Additionally, it allows patients to integrate the treatment into their social and occupational lives. Full article

Recurrent selection for early vigour traits in wheat (Triticum aestivum L.) has provided an opportunity to generate competitive biotypes to suppress agronomically important weeds. Quantifying the potential benefits of competitive genotypes, including yield improvement and reduced frequency of herbicide application when incorporated into a long-term rotation, is vital to increase grower adoption. In this simple economic model, we evaluated a weed-suppressive early vigour genotype utilising on-farm experimental results and simulation analysis to predict gross margins for a seven-year wheat-canola rotation in southeastern Australia. The model applied a local weather sequence and predicted wheat production potential, costs and benefits over time. An early vigour wheat genotype was compared to commercial wheat cultivars for weed control, yield and actual production cost. With respect to weed control, three scenarios were evaluated in the model: standard herbicide use with a commercial cultivar (A), herbicide use reduced moderately by inclusion of an early vigour wheat genotype and elimination of the postharvest grass herbicide (B) or inclusion of an early vigour wheat genotype and withdrawal of both postharvest grass and broadleaf herbicides (C). Cost savings for the use of a competitive wheat genotype ranged from 12 AUD/ha in scenario B to 40 AUD/ha in scenario C, for a total saving of 52 AUD/ha. The model generated annual background gross margins, which varied from 300 AUD/ha to 1400 AUD/ha based on historical weather conditions, production costs and crop prices over the 30-year period from 1992 to 2021. The benefits of lower costs for each of the three scenarios are presented with rolling seven-year average wheat–canola rotation gross margins over the 30-year period. The limitations of this model for evaluation of weed suppression and cost benefits are discussed, as well as relative opportunities for adoption of early vigour traits in wheat. Full article

The impact of antibiotic therapy on the spread of antibiotic resistance genes (ARGs) and its relationship to gut microbiota remains unclear. This study investigated changes in ARGs, mobile genetic elements (MGEs), and gut microbial composition following tilmicosin administration in pigs. Thirty pigs were randomly divided into control (CK), low-concentration (0.2 g/kg; L), and high-concentration (0.4 g/kg; H) groups. Tilmicosin concentration in manure peaked on day 16 of dosing and dropped below detectable levels by day 13 of the withdrawal period. While tilmicosin did not significantly affect the total abundance of macrolide resistance genes (MRGs) (p > 0.05), it significantly increased the abundance of the multidrug resistance gene tolC in the H group compared with the L and CK groups during the withdrawal period (p < 0.05). This increase was associated with a coincidental rise in the abundance of MGEs (e.g., int1 and int2) and the growth of potential tolC-hosting bacteria such as Paenalcaligenes and Proteiniclasticum. Redundancy analysis showed gut microbial composition as the primary driver of MRG abundance, with MGEs, tilmicosin concentration, and manure physicochemical properties playing secondary roles. These findings suggest that high-dose tilmicosin may alter the gut microbiota and promote ARG spread via MGE-mediated transfer. Full article

Brazil stands out as one of the main producers of dimension stones and, in order to maintain sustainable production, the principles of environmental sustainability have been increasingly desired. The importance of studying sludge from dimension stone processing is not only based on the economic and environmental burden that its waste disposal represents for the sector but also on the opportunity to use a material that can reduce the extraction of other mineral goods. This study aimed to describe the characteristics of this sludge at different stages of the processing to evaluate the differences between the material circulating in the production process and after dehydration, when it becomes a residue to be disposed of. Aluminum, iron, manganese, and barium concentrations were high in the liquid phase of the sludge, but they were reduced considerably in the solubilized extract. The hydrogen potential reduced, falling below the threshold of corrosivity, after the withdrawal of the liquid phase. Elements with concentrations higher than the maximum allowed value for inert wastes come from both the inputs used in the processing and the processed stone itself. Initiatives to segregate materials from different sources and investments for the creation of eco-products that can replace inputs, besides the use of wastes, should be encouraged to work towards sustainable production. Full article

As one of the most sensitive areas to climate change in China, the Yellow River Basin faces a significant water resource shortage, which severely restricts sustainable economic development in the region and has become the most prominent issue in the basin. In response to the national strategy of ecological protection and high-quality development of the Yellow River Basin, as well as Sustainable Development Goal 6.4 (SDG 6.4), we applied the water stress index (WSI) to measure water stress in the basin. This analysis utilized land use datasets, socio-economic datasets, irrigation datasets, water withdrawal/consumption datasets, and runoff datasets from 2000 to 2020. We also identified the driving factors of the WSI using a partial least squares regression (PLSR) and assessed spatial clustering with global and local Moran’s indices. The results indicate that water stress in the Yellow River Basin has been alleviated, as indicated by the decreasing WSI due to increased precipitation. However, rising domestic water withdrawals have led to an overall increase in total water withdrawal, with agricultural water use accounting for the largest proportion of total water consumption. Precipitation is the most significant factor influencing water stress, affecting 46.25% of the basin area, followed by air temperature, which affects 12.64% of the area. Other factors account for less than 10% each. Furthermore, the global Moran’s index values for 2000, 2005, 2010, 2015, and 2020 were 0.172, 0.280, 0.284, 0.305, and 0.302, respectively, indicating a strong positive spatial autocorrelation within the basin. The local Moran’s index revealed that the WSI of 446 catchments was predominantly characterized by high–high and low–low clusters, suggesting a strong positive correlation in the WSI among these catchments. This study provides a reference framework for developing a water resources assessment index system in the Yellow River Basin and supports regional water resources management and industrial structure planning. Full article

Objectives: The development of novel long-acting injectables for local anesthetics is necessary to effectively manage the acute postoperative pain. The aim of this study was to prepare an injectable oil-based formulation of ropivacaine (ROP) prodrug (ropivacaine stearoxil, ROP-ST) and to investigate the pharmacokinetics and pharmacodynamics after injectable administration. Methods: A novel N-acyloxymethyl prodrug of ROP, i.e., ROP-ST, was synthesized and its physicochemical properties such as log P, solubility and stability characterized. A soybean oil-based depot of ROP-ST was prepared, and the in-vitro release of ROP-ST was evaluated using an “inverted-cup” method. Pharmacokinetic profiles and tissue retention properties were investigated after intramuscular administration of the formulation in rats. The analgesic efficacy was assessed via a von Frey monofilaments test by measuring the paw withdrawal thresholds. Results: The structure of ROP-ST was ascertained with clear ¹H NMR assignment and accurate mass-to-charge ratio. The high Log P value of ROP-ST (9.16) demonstrated extremely low aqueous solubility, but the prodrug is biolabile when in contact with plasma or liver esterase. Intramuscular injection of ROP-ST oil solution in rats provided a significantly higher mean residence time without a very clear plasma peak of ROP. In a postoperative pain model of rats, the injection of ROP-ST oil solution into the vicinity of the sciatic nerve in the right ankle effectively controlled the postoperative pain for at least 72 h. Conclusions: The injectable oil-based depot formulation of N-acyloxymethyl prodrug of ROP may provide a new opportunity of long-acting local analgesia for postoperative pain. Full article

Background/Objectives: Hyperkalemia is a common electrolyte disorder in patients with heart failure and reduced ejection fraction (HFrEF). Renin-angiotensin-aldosterone system inhibitors (RAASi) have been shown to improve survival and decrease hospitalization rates, although they may increase the serum potassium levels. Hyperkalemia has significant clinical and economic implications, and is associated with increased healthcare resource utilization. The objective of the study was to analyze the management of hyperkalemia and the associated medical costs in a cohort of patients with HFrEF. Methods: An observational, longitudinal, retrospective, single-center retrospective study was conducted in patients with HFrEF who started follow-up in a heart failure unit between 2010 and 2021. Results: The study population consisted of 1181 patients followed-up on for 64.6 ± 38.8 months. During follow-up, 11,059 control visits were conducted, documenting 438 episodes of hyperkalemia in 262 patients (22.2%). Of the hyperkalemia episodes, 3.0% required assistance in the Emergency Department, 1.4% required hospitalization, and only 0.2% required admission to the Intensive Care Unit. No episode required renal replacement therapy. Reduction or withdrawal of RAASi was necessary in 69.9% of the hyperkalemia episodes. The total cost of the 438 hyperkalemia episodes was €89,178.82; the expense during the first year accounted for 48.8% of the total cost. Conclusions: Hyperkalemia is frequent in patients with HFrEF. It is often accompanied by a modification of treatment with RAASi. Hyperkalemia generates substantial costs in terms of healthcare resources and medical care, especially during the first year. Full article

The purpose of this study was to examine the association between behavioral emotion regulation strategies and symptoms of depression, anxiety, and stress among Turkish university students. Participants consisted of 633 students continuing their university education in two different universities in Türkiye. Participants completed a data collection tool comprising a Sociodemographic Information Form, the Behavioral Emotion Regulation Questionnaire, and the Depression Anxiety Stress Scales-21. Data were analyzed using descriptive statistics, Pearson’s product-moment correlation coefficient analysis, and multivariate multiple regression analysis. The results of this study revealed that seeking distraction was negatively associated with symptoms of depression, anxiety, and stress, whereas withdrawal, seeking social support, and ignoring were positively associated with symptoms of depression, anxiety, and stress among university students. Additionally, actively approaching was negatively associated with depressive symptoms. Overall, the findings demonstrate that university students who use maladaptive behavioral emotion regulation strategies (e.g., withdrawal, ignoring) tend to have higher levels of psychological distress, whereas university students who use adaptive emotion regulation strategies (e.g., distraction) tend to have lower levels of psychological distress. However, contrary to expectations, seeking social support was positively associated with symptoms of psychological distress. Given the paucity of research on the relationship between behavioral emotion regulation strategies and psychological distress in the Turkish cultural context, this study may contribute to identifying both universal and culturally specific strategies associated with depressive, anxiety, and stress symptoms among Turkish university students. Full article

Background: The current possible treatments of advanced medullary carcinoma (MTC) include different drugs belonging to the class of tyrosine kinase inhibitors (TKIs): vandetanib, cabozantinb, and selpercatinib. Although the effects of these TKIs have been well described in clinical trials, the real-practice evidence of the effectiveness and safety of these treatment is scant. This real-world case series aims to describe a niche of patients with advanced MTC treated with more than one TKI by focusing on treatment responses and any reported adverse events (AEs) and to provide additional insight on the individualized approach to the management of metastatic MTC. Methods: Five patients with a diagnosis of metastastic MTC, treated with at least two different molecules of TKIs, were retrospectively selected. Results: Three patients obtained a partial response (one with cabozantinb, one with selpercatinib, and one with vandetanib), and two patients obtained disease stability (both of them treated with all three TKIs, the first two lines discontinued for AEs). The AE profile agreed with the known clinical trials AEs except for non-neoplastic ascites related to selpercatinib and lung cavitations of non-neoplastic tissue related to cabozantinb. The latter was an AE never described so far in patients receiving TKIs. Conclusions: The best management of MTC relies on an individualized approach, keeping in mind and dealing with the potential toxicity in order to minimize the treatment withdrawal. Full article

The objective of this study was to examine the residue elimination patterns of seven antibiotics in the eggs of Taihang chickens under free-range conditions and develop suitable withdrawal times (WDTs). A total of 240 healthy Taihang chickens, aged 180 days, were randomly divided into eight groups of 30 birds each. The first seven groups were administered oxytetracycline, chlortetracycline, erythromycin, tylosin, tylvalosin, lincomycin, and tiamulin, respectively, in accordance with the maximum dosages and longest durations of treatment recommended by the Veterinary Pharmacopoeia of the People’s Republic of China. Group 8 served as the control group, and the test period continued until no drug residue could be detected. The results demonstrate that the residues of oxytetracycline, chlortetracycline, tylosin, tylvalosin, and tiamulin throughout the test period were below the maximum residue limits (MRLs) outlined in GB 31650-2019, “National food safety standard-Maximum residue limits for veterinary drugs in foods”. The egg yolk was identified as the target tissue for estimating the withdrawal time periods (WDTs) of these seven drugs. It was thus concluded that the recommended withdrawal time for tiamulin should be 0 days. However, the WDTs of oxytetracycline, chlortetracycline, tylosin, tylvalosin, were 2.8, 0.3, 2.4, and 7.4, respectively, when the upper limit of the 95% confidence interval was found to be lower than the MRLs. It was thus determined that the recommended WDTs for oxytetracycline, chlortetracycline, tylosin, and tylvalosin should be 3, 1, 3, and 8 days, respectively. In contrast, erythromycin and lincomycin exhibited concentrations below the permitted MRLs on days 7 and 8, respectively. However, the upper limits of the 95% confidence intervals for erythromycin and lincomycin were found to be below the MRLs when the WDTs were 11 and 8.9, respectively. This suggests that the recommended WDTs for these two antibiotics should be 11 days and 9 days. Full article