Search Results (8,344)

Heart failure, a major public health issue, often stems from prolonged stress or damage to the heart muscle, leading to cardiac hypertrophy. This can progress to heart failure and other cardiovascular problems. Doxorubicin (DOX), a common chemotherapy drug, and isoproterenol (ISO), a β-adrenergic agonist, both induce cardiac hypertrophy through different mechanisms. This study investigates TongGuanWan (TGW,), a traditional herbal remedy, for its effects on cardiac hypertrophy and fibrosis in DOX-induced H9c2 cells and ISO-induced mouse models. TGW was found to counteract DOX-induced increases in H9c2 cell surface area (n = 8, p < 0.01) and improve biomarkers like ANP (n = 3, p < 0.01)) and BNP (n = 3, p < 0.01). It inhibited the MAPK pathway (n = 4, p < 0.01) and GATA-4/calcineurin/NFAT-3 signaling, reduced inflammation by decreasing NF-κB p65 translocation, and enhanced apoptosis-related factors such as caspase-3 (n = 3, p < 0.01), caspase-9 (n = 3, p < 0.01), Bax (n = 3, p < 0.01), and Bcl-2 (n = 3, p < 0.01). Flow cytometry showed TGW reduced apoptotic cell populations. In vivo, TGW reduced heart (n = 8~10, p < 0.01), and left ventricle weights (n = 6~7), cardiac hypertrophy markers (n = 3, p < 0.01), and perivascular fibrosis in ISO-induced mice, with Western blot analysis confirming decreased levels of fibrosis-related factors like fibronectin, α-SMA (n = 3, p < 0.05), and collagen type I (n = 3, p < 0.05). These findings suggest TGW has potential as a therapeutic option for cardiac hypertrophy and fibrosis. Full article

The Ramganga River basin, comprising three rivers, the Dhela, Dhandi, and Ramganga, plays a vital role in groundwater recharge, sustaining numerous industries, urban areas, and rural communities reliant on these rivers for daily activities. The study’s primary purpose was to analyze the groundwater quality in the context of potability, irrigation, and health risks to the local inhabitants of the Ramganga River basin. In 2021–2022, 52 samples (26 × 2) were collected from 13 locations in two different seasons, i.e., pre-monsoon and post-monsoon, and 20 physico-chemical and heavy metal and metalloids were analyzed using the standard protocols. The result shows that heavy metal and metalloids and metalloid concentrations of Zn (0.309–1.787 and 0.613–1.633); Fe (0.290–0.965 and 0.253–1.720), Cd (0.001–0.002 and 0.001–0.002); As (0.001–0.002 and 0.001–0.002), Cr (0.009–0.027 and 0.011–0.029), and Pb (−0.001–0.010 and 0.00–0.010) values in mg/L are present in both seasons. The groundwater quality index (GWQI), heavy metal pollution Index (HPI), and heavy metal evaluation index (HEI) were used to assess the water quality and metal pollution in the basin area. As per GWQI values, water quality lies from excellent water quality (41.639 and 43.091) to good water quality (56.326 and 53.902); as per HPI values, it shows good (29.51 and 30.03) to poor quality (60.26 and 59.75) and HEI values show the low-level contamination (1.03–2.57 and 1.13–3.37) of heavy metal and metalloids in both seasons. According to the potential health risk assessment, infants show low risk in pre-monsoon and low risk to medium post-monsoon, while children and adults show low risk to high risk in both seasons. From the health risk perspective, it shows that children and adults have more concerns about non-carcinogenic effects, so adequate remedial measures and treatment are required to avoid the groundwater quality of the Ramganga River basin. Full article

In the environmental field, the advancement of new high-efficiency heavy metal adsorption materials remains a continuous research focus. A novel composite, covalent organic framework-modified biochar (RH-COF), was fabricated via an in-situ polymerization approach in this study. The COF-modified biochar was characterized by elemental analysis, BET analysis, SEM, FT-IR, and XPS. The nitrogen and oxygen content in the modified material increased significantly from 0.96% and 15.50% to 8.88% and 22.37%, respectively, indicating the addition of a substantial number of nitrogen- and oxygen-containing functional groups to the RH-COF surface, thereby enhancing its adsorption capacity for Cd from 4.20 mg g⁻¹ to 58.62 mg g⁻¹, representing an approximately fourteen-fold increase. Both the pseudo-second-order model and the Langmuir model were suitable for describing the kinetics and isotherms of Cd²⁺ adsorption onto RH-COF. The adsorption performance of Cd²⁺ by RH-COF showed minimal sensitivity to pH values between 4.0 and 8.0, but could be slightly influenced by ionic strength. Mechanistic analysis showed that the Cd²⁺ adsorption on RH-COF was dominated by surface complexation and chelation, alongside electrostatic adsorption, surface precipitation, and Cπ–cation interactions. Overall, these findings suggest that the synthesis of COF-biochar composite may serve as a promising remediation strategy while providing scientific support for applying COF in environmental materials. Full article

This study investigates the potential of Chlorella vulgaris for nutrient removal and biomass production in synthetic wastewater. The experiments were conducted in 2 L photobioreactors under controlled aeration, agitation, and lighting conditions for 19 days. Despite a moderate growth rate (0.137 d⁻¹), C. vulgaris achieved efficient pollutant removal, with 97% of nitrate, 90% of nitrite, and 90.6% of COD eliminated. Additionally, the biomass was processed to extract fatty acids, yielding a 20% extraction rate, indicating its potential as a biofuel feedstock. These results demonstrate C. vulgaris’s dual function in wastewater remediation and biofuel production, presenting a sustainable and economically viable approach to addressing environmental challenges. Full article

For many decades, natural and modified clay minerals have been used as adsorbents to clean up aquatic and soil ecosystems contaminated with organic and inorganic pollutants. In this study, organoclays based on bentonite and various amphoteric and nonionic surfactants were synthesized and tested as effective sorbents for lead ions. The maximum values of R were obtained when describing the sorption processes using the Langmuir model, which ranged from 0.97 to 0.99. The adsorption of lead ions by these organoclays was investigated using different sorption models including the Langmuir, Freundlich, and BET. It was found that, according to the values of limiting adsorption to the Langmuir equation, the synthesized organoclays formed an increasing series: organoclay with cocamide diethanolamine < bentonite < organoclay with lauramine oxide < organoclay with sodium cocoiminodipropionate < organoclay with disodium cocoamphodiacetate < organoclay with alkyl polyglucoside. The Gibbs energy for all of the analyzed samples was calculated and found to be negative, indicating the spontaneity of the cation adsorption process in the forward direction. The maximum value of the adsorption capacity of lead cations on organoclay-based bentonite with alkyl polyglucoside was 1.49 ± 0.05 mmol/g according to the Langmuir model, and 0.523 ± 0.003 mmol/g as determined by the BET model. In the process of modifying bentonite, there was an increase in negative values of the zeta potential for organoclays compared to the initial mineral, which clearly enhanced their electrostatic interactions with the positively charged lead ions. It was hypothesized, based on the physicochemical principles, that exchange adsorption is the main mechanism for lead absorption. Based on chemical approaches, organoclays based on amphoteric surfactants absorb lead mainly through the mechanisms of electrostatic attraction, ion exchange, and complexation as well as the formation of insoluble precipitates. Organoclays based on nonionic surfactants, on the other hand, absorb lead through mechanisms of complexation (including chelation) and the formation of insoluble chemical precipitates. The comparison of isotherms from different models allows us to find the most accurate match between the model and the experimental data, and to better understand the nature of the processes involved. Full article

The increasing pollution of water bodies, due to the constant release of highly toxic and non-biodegradable organic pollutants, requires innovative solutions for environmental remediation and wastewater treatment. In this study, the effectiveness of different Advanced Oxidation Processes (AOPs) for the purification of water contaminated with Rhodamine B (RhB) dye at a concentration of 5 mg/L were investigated and compared. Using the classical ozonation strategy as a benchmark treatment, the research showed over 99% degradation of RhB within 4 min in a laboratory-scale batch setup with a capacity of 0.2 L. In contrast, a “chemical-free” process exploiting ultrasound (US) technology achieved a 72% degradation rate within 60 min. Further experiments were conducted using a pilot-scale rotor-stator hydrodynamic cavitation (HC) reactor on a 15 L solution leading to 33% of RhB removal in the presence of hydrogen peroxide (H₂O₂) at 75 mg/L. However, the use of an innovative cavitational reactor, which hybridizes HC with cold plasma, showed remarkable efficiency and achieved 97% degradation of RhB in just 5 min when treating a 5 L solution at an inlet pressure of 20 bar in a loop configuration. In addition, a degradation rate of 58% was observed in a flow-through configuration, emphasising the robustness and scalability of the HC/electrical discharge (ED) plasma technology. These results underline the potential of hybrid HC/ED plasma technology as an intensified and scalable process for the purification of water, as it offers a catalyst- and oxidant-free protocol. Full article

China’s arid regions are particularly vulnerable to the adverse effects of climate change and human activities, which pose threats to habitat quality. Consequently, evaluations of these effects are vital for devising ecological strategies and initiating regional remediation efforts. However, environmental variations in arid areas can cause habitat quality fluctuations, which complicates precise assessments. This study introduces a refined methodology that integrates remote sensing data and field survey biomass data to modify the habitat quality estimates obtained from the InVEST model in the Altai region over three decades. A comparative analysis of the unmodified, normalized difference vegetation index (NDVI)-modified and biomass-modified habitat quality estimates was conducted. The results revealed an improvement in the correlation between habitat quality and field observations, with a significant increase in the R² value from 0.129 to 0.603. The unmodified model exhibits subtle variations in habitat quality in mountainous areas, with a slight decline in the plains. However, the modified model shows an increasing trend in mountainous areas. This finding contrasts with the reductions in mountains typically reported by other studies. The refined approach accurately expresses the variations in habitat quality across different habitat types, with declines in forested areas and improvements in shrubland and grassland regions. This model is suitable for arid regions and accommodates urban and agricultural ecosystems affected by human activities, offering empirical data for biodiversity and habitat management. Full article

The exogenous application of oxalic acid is a potential approach to amplifying phytoremediation performance on Cd-contaminated soils. However, few studies explore the optimal oxalic acid application regime from a perspective of coupling different concentrations and timings to maximize Cd removal rate. Given this, a pot experiment was conducted using oil sunflower (Helianthus annuus L.) as the test plant. Oxalic acid was added to the pots at concentrations of 1, 2, 3, 4, 5, and 6 mmol/kg at 20, 30, 40, and 50 days after emergence. A control (CK) without exogenous oxalic acid was also included. We examined the discrepancies in various soil Cd forms, sunflower height, plant non-protein thiol (NPT) levels, and soil Cd remediation efficiency under different oxalic acid application regimes. The results showed that applying oxalic acid at a concentration of 4 mmol/kg reduced the proportion of Fe-Mn oxide Cd and organic Cd compared to the control (CK), while increased the proportion of available Cd. The optimal application time is 30 or 40 days after emergence. The addition of exogenous oxalic acid promoted the growth of sunflowers, with the greatest increase in plant height observed when 4 mmol/kg oxalic acid was applied at 30 days after emergence. Exogenous oxalic acid enhanced the absorption of Cd by sunflower roots, with the total Cd accumulation in roots, stems, and leaves being higher than in the control (CK). When 4 mmol/kg oxalic acid was applied at 30 days after emergence, the total Cd accumulation in roots, stems, and leaves was highest. Under different application times and concentration levels of oxalic acid, Cd accumulation was highest in roots, followed by leaves, with stems showing the lowest accumulation. The NPT content in each part is as follows: root > stem > leaf. Applying 5 mmol/kg oxalic acid after 30 days of sunflower emergence resulted in relatively higher total NPT content in roots, stems, and leaves compared to the control (CK). The TOPSIS model was used for comprehensive evaluation, which showed that 4 mmol/kg oxalic acid application at 30 days after emergence could be used as the optimal oxalic acid application regime for phytoremediation. These findings indicate that the addition of oxalic acid effectively promoted the absorption of Cd by sunflower and increased the efficiency of Cd removal from the rhizosphere soil, with the optimal removal of soil Cd achieved by applying oxalic acid at a concentration of 4 mmol/kg 30 days after the emergence of oilseed sunflower seedlings. Full article

Anodic TiO₂ nanotube arrays decorated with Ni, Cu, and NiCu alloy thin films were investigated for the first time for the photocatalytic degradation of paracetamol in water solution under UV irradiation. Metallic co-catalysts were deposited on TiO₂ nanotubes using magnetron sputtering. The influence of the metal layer composition and thickness on the photocatalytic activity was systematically studied. Photocatalytic experiments showed that only Cu-rich co-catalysts provide enhanced paracetamol degradation rates, whereas Ni-modified photocatalysts exhibit no improvement compared with unmodified TiO₂. The best-performing material was obtained by sputtering a 20 nm thick film of 1:1 atomic ratio NiCu alloy: this material exhibits a reaction rate more than doubled compared with pristine TiO₂, enabling the complete degradation of 10 mg L⁻¹ of paracetamol in 8 h. The superior performance of NiCu-modified systems over pure Cu-based ones is ascribed to a Ni and Cu synergistic effect. Kinetic tests using selective holes and radical scavengers unveiled, unlike prior findings in the literature, that paracetamol undergoes direct oxidation at the photocatalyst surface via valence band holes. Finally, Chemical Oxygen Demand (COD) tests and High-Resolution Mass Spectrometry (HR-MS) analysis were conducted to assess the degree of mineralization and identify intermediates. In contrast with the existing literature, we demonstrated that the mechanistic pathway involves direct oxidation by valence band holes. Full article

Here, we highlight the research presented in this Special Issue, focusing on the innovative use of graphene and other two-dimensional (2D) materials to develop advanced coating technologies. The contributions herein address critical challenges such as the scalable fabrication and stable dispersion of such materials and their compatibility with conventional coating systems, offering solutions that enhance their mechanical strength, chemical stability, and multifunctionality. The featured studies demonstrate the diverse applications of these materials, from protective anticorrosive barriers to high-performance optoelectronic devices and environmental remediation. Moving forward, future research is encouraged to explore novel 2D materials, hybrid coating strategies, and advanced computational modeling to overcome existing limitations and unlock new possibilities. Full article

We present a novel miniaturized, gear-shaped, fuel-free actuator capable of autonomously propelling itself in an aquatic environment to absorb heavy metals, such as copper ions. While hydrogel-based absorbents are promising solutions for cationic pollutant remediation, their stationary nature limits their effectiveness in areas where contaminants are unevenly distributed. To address this, we developed a bio-inspired soft actuator that mimics natural propulsion mechanisms. The Marangoni effect, driven by its inherent chemical properties, demonstrated a self-propelled motion without requiring external fuel. The proof-of-concept actuator generated a plane motion lasting up to 2 h and swept over an area approximately 400 times bigger than its size. By harnessing the chemical and optical properties of the hydrogel, we efficiently removed and quantitatively analyzed copper ions through a colorimetric method. This innovative integration of self-propelled movement and efficient copper ion absorption underscores its potential for advancing miniaturized devices in environmental remediation, paving the way for more active and efficient pollutant removal systems in challenging aquatic environments. Full article

Plants growing in heavy metal (HM)-contaminated soil have evolved a special detoxification mechanism. The rhizosphere gathers many living substances and their secretions at the center of plant roots, which has a unique ecological remediation effect. It is of great significance to thoroughly understand the ecological process of rhizosphere pollution under heavy metals (HMs) stress and develop biotechnology for joint remediation using plants and their coexisting microbial systems according to the mechanism of rhizosphere stress. Microbes can weaken the toxicity of HM pollutants by transforming the existing forms or reducing the bioavailability in the rhizosphere. Microbes survive in the HM-polluted soils through the production of stress-resistant substances, the participation of proteins, and the expression of heavy metal resistance genes, which strengthens the resistance of plants. Moreover, microbes can improve the nutritional status of plants to improve plant resistance to HMs. Plants, in turn, provide a habitat for microbes to survive and reproduce, which greatly accelerates the process of bioremediation. Briefly, the combined remediation of soil HMs pollution by plants and microbes is a promising, green, and sustainable strategy. Here, we mainly elucidate the joint remediation mechanism of plant–microbe symbiosis and introduce the coping characteristics of plants, microbes, and their symbiotic system, hoping to provide a scientific basis for the remediation of HM-contaminated soil in mining areas and the sustainable development of the ecological environment. Full article

Background: Previous studies of the hydroethanolic extract of Virola elongata inner stem bark (HEVe) have demonstrated its antioxidant, gastroprotective, and antiulcer properties, but have not evaluated its anti-inflammatory potential. Methods: HEVe was obtained by maceration and phytochemically analyzed. Its systemic anti-inflammatory activity was assessed by its effect on lipopolysaccharide (LPS)-induced peritonitis in mice. HEVe gel (HEgVe) was employed to evaluate topical anti-inflammatory activity by measuring the ear edema resulting from croton-oil-induced dermatitis in mice. A cell viability assay was conducted to determine the non-cytotoxic concentrations of the HEVe. RAW 264.7 cells were stimulated by LPS to determinate cytokine and nitric oxide production. Results: A phytochemical analysis of the HEVe revealed the presence of phenolic acids, neolignans, flavonoids, and monomeric catechins. The oral treatment of acute peritonitis with HEVe reduced the total leukocytes, neutrophils, TNF-α, and IL-1β and elevated IL-10 levels. The application of the HEgVe reduced local edema. The HEVe on the RAW 264.7 cells exhibited no cytotoxicity, and the cells with HEVe displayed reduced TNF-α, IL-1β, and NO levels and increased IL-13 levels. Conclusions: HEVe demonstrated systemic and topical multitarget anti-inflammatory activity, likely due to the combined effects of secondary metabolites. HEVe emerges as a promising herbal remedy for inflammation with minimal cytotoxicity, emphasizing its potential therapeutic significance. Full article

Background/Objectives: Metabolic-associated fatty liver disease (MAFLD) is one of the most common liver disorders associated with obesity and metabolic syndrome, and poses a significant global health burden with limited effective treatments. The aim of this study was to assess the protective effects of mulberry twig alkaloids (SZ-A) on MAFLD and to further investigate the underlying mechanisms including the specific targets or pathways. Methods: Diet-induced obesity (DIO) and normal mouse models were established by feeding C57Bl/6J mice with a high-fat diet (HFD) or common diet for 12 weeks. SZ-A, dapagliflozin, and placebo were administered to corresponding mouse groups for 8 weeks. Data of fasting blood glucose, glucose tolerance, insulin tolerance, and the body weight of mice were collected at the baseline and termination of the experiment. Serum liver enzymes and lipids were measured by ELISA. Western blotting, qPCR, and pathological section staining were implemented to evaluate the degrees of liver steatosis, fibrosis, and oxidative stress in mice. Results: In DIO mouse models, high-dose SZ-A (800 mg/kg/d) treatment significantly inhibited HFD-induced weight gain, improved insulin tolerance, and reduced serum alanine aminotransferase, total cholesterol, and triglyceride levels compared with placebo. In DIO mice, SZ-A could alleviate the pathological changes of hepatic steatosis and fibrosis compared with placebo. Lipid catabolism and antioxidant stress-related proteins were significantly increased in the livers of the high-dose SZ-A group (p < 0.05). Inhibition of PGC1α could inhibit the function of SZ-A to enhance lipid metabolism in hepatocytes. PGC1α might interact with NRF2 to exert MAFLD-remedying effects. Conclusions: By regulating the expression of PGC1α and its interacting KEAP1/NRF2 pathway in mouse liver cells, SZ-A played important roles in regulating lipid metabolism, inhibiting oxidative stress, and postponing liver fibrosis in mice with MAFLD. Full article

Diabetes mellitus (DM) is a common non-communicable and chronic metabolic disorder regarded as a global epidemic with high morbidity and mortality. Although, conventional medicines are available for the management of DM, Indigenous knowledge, including the use of botanicals, has contributed to the management of this life-threatening disease in Africa. This is due to the perceived effectiveness and minimal side effects associated with plants and plant-derived compounds as an affordable remedy against DM. This review focuses on the contribution of Indigenous African plants to the management of DM. Relevant literatures were reviewed from online scientific databases, such as PubMed, ScienceDirect, and Google Scholar, using keywords singly and in combination. The review revealed that Indigenous health practitioners use several medicinal plants in the management of DM, with a range of 14–255 botanicals recorded. Approximately 80 compounds with antidiabetic potency have been isolated from different parts of African medicinal plants, with the majority belonging to flavonoids and terpenoids. Particularly, compounds such as apigenin, combretin B, convallatoxin, kaempferol, and quercetin remain the most promising antidiabetic compounds isolated from African medicinal plants. Limited clinical trials have been conducted on these compounds despite these milestones. There is, therefore, the need for further investigations to explain their antidiabetic effects, particularly under clinical conditions. Plants from which these compounds were isolated were selected based on ethnopharmacological knowledge. With these developments, medicinal plants and Indigenous knowledge remain an integral part of the global strategy to combat DM. Full article