Search Results (395)

Dysmenorrhea, or painful menstruation, is one of the most prevalent conditions among adolescents and young females globally, significantly affecting academic performance, quality of life, and social interactions. Despite its high prevalence, dysmenorrhea has been rarely investigated in Saudi Arabia, resulting in a scarcity of national data. This study aimed to evaluate the prevalence, severity, and determinants of dysmenorrhea among females in Saudi Arabia. This cross-sectional, questionnaire-based study included 1026 participants recruited from various regions of Saudi Arabia using a convenience sampling technique. Data collection was conducted using a validated, self-administered online questionnaire. Descriptive and inferential statistics were utilized to evaluate the prevalence, severity, and associated symptoms of dysmenorrhea. Additionally, multiple logistic regression was employed to identify the determinants of dysmenorrhea within the sample. The analysis was performed using R software. The prevalence of dysmenorrhea among the sample was 87%, with a mean pain score of 6 ± 2.2. Common menstrual cycle-associated symptoms included mood swings (79%), abdominal bloating (60%), diarrhea (32%), and constipation (26%). Factors associated with an increased risk of dysmenorrhea included Saudi nationality (OR = 1.96, p = 0.032), employment (OR = 1.75, p = 0.034), and a history of gynecological surgeries (OR = 1.81, p = 0.045). Conversely, multiparity was associated with a reduced risk of dysmenorrhea (OR = 0.36, p = 0.046). Dysmenorrhea is highly prevalent among Saudi women and is accompanied by significant menstrual symptoms that adversely affect quality of life. Understanding its determinants and associated symptoms is essential for improving management strategies and mitigating its impact on women’s lives. Full article

Temperature and host fruit availability are key factors influencing the life history traits of the Mediterranean fruit fly (medfly) (Ceratitis capitata). This study examines how developmental temperature and host fruit type affect adult longevity and fecundity in medflies from six populations spanning Southern to Central Europe. Larvae were reared on apples and bitter oranges at three constant temperatures (15, 20, and 25 °C), with pupae maintained under the same thermal conditions until adult emergence. Adults were then kept at 25 °C, with longevity and fecundity recorded daily. The results showed that higher developmental temperatures increased adult lifespan across all populations, regardless of host fruit. Similarly, fecundity rates in ovipositing females were higher at higher temperatures. Reproductive periods (pre-oviposition, oviposition, and post-oviposition) varied among populations, indicating population-specific responses. These findings underscore how temperature and host fruit availability shape medfly invasion dynamics, highlighting the species’ biological plasticity and adaptation to different environments. This research provides valuable insights for pest management, particularly in the context of climate change, offering strategies to mitigate the spread of medflies into new regions. Full article

Depression poses significant challenges to global healthcare systems and impacts the quality of life of individuals and their family members. Recent advancements in artificial intelligence (AI) have had a transformative impact on the diagnosis and treatment of depression. These innovations have the potential to significantly enhance clinical decision-making processes and improve patient outcomes in healthcare settings. AI-powered tools can analyze extensive patient data—including medical records, genetic information, and behavioral patterns—to identify early warning signs of depression, thereby enhancing diagnostic accuracy. By recognizing subtle indicators that traditional assessments may overlook, these tools enable healthcare providers to make timely and precise diagnostic decisions that are crucial in preventing the onset or escalation of depressive episodes. In terms of treatment, AI algorithms can assist in personalizing therapeutic interventions by predicting the effectiveness of various approaches for individual patients based on their unique characteristics and medical history. This includes recommending tailored treatment plans that consider the patient’s specific symptoms. Such personalized strategies aim to optimize therapeutic outcomes and improve the overall efficiency of healthcare. This theoretical review uniquely synthesizes current evidence on AI applications in primary care depression management, offering a comprehensive analysis of both diagnostic and treatment personalization capabilities. Alongside these advancements, we also address the conflicting findings in the field and the presence of biases that necessitate important limitations. Full article

COPD is one of the leading causes of death worldwide, so it represents a significant public health challenge. Over the years, new effective therapies have been proposed. However, the burden of COPD is still conditioned by frequent acute events defined as exacerbations (exacerbation of COPD-ECOPD), which have a significant impact not only on the patient’s quality of life but also on the progression of the disease, morbidity, and mortality. Related to the severity of the condition, ECOPD may require hospital admission and often repeatedly more admissions (readmission). The phenomenon of readmissions is a significant problem, contributing substantially to the utilisation of healthcare resources and the economic burden of COPD. Related contributing factors are still poorly understood, and managing the patients readmitted to the hospital with ECOPD may be challenging. Hospital readmissions should be optimally managed, including supporting and preventive strategies. Although early readmissions (30 days from discharge) are a marker of the quality of the patient’s care, we need to consider COPD patients globally. It is not sufficient to address just the acute events, so multidimensional management is necessary, able to follow the patient over time to identify, by a personalised approach, the correct treatment during and post hospitalisation and intercept any factor affecting the natural history of the disease, comprising the risk of hospital readmissions. In the context of the literature concerning respiratory medicine, particularly COPD patients, our narrative review analyses recent evidence regarding the current management of COPD hospital readmissions, aiming to propose preventive strategies helpful in clinical practice. The proposed strategies can potentially improve clinical outcomes and reduce healthcare costs when effectively implemented in practice. Full article

Prostate cancer is one of the most common diseases among men worldwide and continues to pose a serious threat to health. This review shows the history and the new developments in the management of prostate cancer, with an emphasis on a range of therapeutic approaches, such as hormone therapy, radiation therapy, surgery, and innovative targeted therapeutics. The evolution of these treatments is examined in light of clinical outcomes, patient quality of life, and emerging resistance mechanisms, such as the recently shown vitamin D-based strategies. New developments that have the potential to increase survival rates and reduce side effects are also discussed, including PARP inhibitors (PARPis), immunotherapy, and tailored medication. Additionally, the use of biomarkers and sophisticated imaging methods in therapeutic decision-making is explored, with a focus on how these tools might improve patient care. The absolute necessity for a multidisciplinary approach for improving treatment strategies is becoming more and more apparent as our understanding of the biology of prostate cancer deepens. This approach ensures that patients receive customized medicines that fit their unique profiles. Future avenues of investigation will focus on resolving issues dealing with treatment efficacy and resistance to improve treatment results, ultimately leading to disease cure for prostate cancer patients. Full article

Background and Clinical Significance: Cardiomyopathy is a significant cause of mortality in patients with Duchenne muscular dystrophy (DMD). Key prognostic factors include the age of onset of cardiomyopathy, low body mass index (BMI), and poor respiratory function. Detection of cardiac abnormalities can be challenging, which complicates timely diagnosis and treatment. Common treatments for heart failure include ACE inhibitors, beta-blockers, and mineralocorticoids. However, their effectiveness can vary, and the progression of cardiomyopathy may differ from one patient to another. Ongoing research aims to identify better therapeutic strategies and biomarkers for early intervention, ultimately improving the quality of life for patients affected by cardiomyopathy. New medications for heart failure, such as sodium/glucose co-transporter 2 inhibitors (SGLT2i) and valsartan/sacubitril (V/S), have been proposed, but their safety and efficacy in DMD patients remain unknown. Case Presentation: We present two cases that illustrate the histories of two patients who experienced different outcomes. The management of the first patient was complicated by several factors, including an early onset of cardiomyopathy, intolerance to ACE inhibitors, and untreated scoliosis, which hindered the implantation of a cardioverter defibrillator (ICD). Unfortunately, he only benefited from dapagliflozin in the later stages of his cardiomyopathy. Neurological complications further exacerbated the advanced state of his disease. In contrast, the second patient adhered to all recommended therapies, including innovative medications, and he currently has compensated heart failure. Conclusions: We concluded that several factors, beyond genetic ones, may have influenced their prognosis, including updated guidelines for cardiomyopathy treatment and the utilization of innovative medications. Full article

In May 2008, Chaitén volcano entered an eruptive process, leading to one of the world’s largest eruptions in recent decades. The magnitude of tephra ejected by the eruption left different types of disturbances and caused diverse forms of environmental damage that were heterogeneously distributed across the surrounding area. We went to the field to assess the early vegetation responses a year after the eruption in September 2009. We evaluated the lateral-blast disturbance zone. We distributed a set of plots in three disturbed sites and one in an undisturbed site. In each of these sites, in a rectangular plot of 1000 m², we marked all standing trees, recording whether they were alive, resprouting, or dead. Additionally, in each site of 80 small plots (~4 m²), we tallied the regenerated plants, their coverage, and the log volume. We described whether the plant regeneration was occurring on a mineral or organic substrate (i.e., ash or leaf litter, respectively). In the blast zone, the eruption created a gradient of disturbance. Close to the crater, we found high levels of devastation marked by no surviving species, scarcely standing-dead trees and logs, and no tree regeneration. At the other extreme end of the disturbance zone, the trees with damaged crowns were resprouting, small plants were regrowing, and seedlings were more dispersed. The main form of regeneration was the resprouting of trunks or buried roots; additionally, a few seedlings were observed in the small plots and elsewhere in disturbed areas. The results suggest that the early stages of succession are shaped by life history traits like dispersion syndrome and regeneration strategy (i.e., vegetative), as was found after other volcanic eruptions. Likewise, the distribution of biological legacies, which is related to disturbance intensity, can cause certain species traits to thrive. For instance, in the blow-down zone, surviving species were chiefly those dispersed by the wind, while in the standing-dead zone, survivors were those dispersed by frugivorous birds. Additionally, we suggest that disturbance intensity variations are related to the elevation gradient. The varying intensities of disturbance further contribute to these ecological dynamics. The early succession in the blast zone of Chaitén volcano is influenced by the interaction between species-specific life history, altitudinal gradient, and biological legacies. Further studies are required to observe the current successional patterns that occur directly in the blast zone and compare these results with those obtained following other volcanic disturbances. Full article

Body size is one of the most important traits in the life history of vertebrates. In this work, we analyzed the morphometric traits of breeding males of the eastern Pacific green sea turtle population known as the black sea turtle on the coast of Michoacan, Mexico. The morphometric analysis indicates that males have the smallest body size compared to other males in other Chelonia populations. The size of male black sea turtles is even smaller (by 15.2 cm in average CCL) in carapace curve length (70.5 cm CCL) than females (85.7 CCL) of the same population. This suggests that males reach maturity at an earlier age than females and would have implications for mating success. The assessment of the operational sex ratio was conducted over a multi-year period (2004, 2009, 2017, and 2023). From a total of 336 h of observation, we identified 653 mating groups containing 1986 males and 669 females. The estimated operational sex ratio (OSR) during the study period was 2.96 males for every female. Among the mating groups, 34.3% consisted of only one male, while 65.7% included two or more males, with the number of males per female ranging from 2 to 17. The analysis revealed that there are interannual and monthly variations in OSR values, with observations showing a range from 2.3:1 (male to female) in 2023 to 4.3:1 (male to female) in 2009. The OSR variations show an evolving trend that can inform future strategies. In September, the ratio was 2.8:1, which changed to 3:1 in October and November, and then reached 3.3:1 in December (male/female). This gradual increase provides a clear opportunity to delve deeper into these dynamics and take proactive measures to address them positively. Full article

Biological data, such as length–weight relationships, are essential for the management and stewardship of harvested individuals. Sea cucumbers are a lucrative industry globally but many of the associated fisheries lack species-level biological data, which reduces the effectiveness of any management strategy. The Queensland Sea Cucumber Fishery (QSCF) on the Great Barrier Reef is managed through various controls: primarily catch limits, effort limits, zoning, and size restrictions. Over 20 species may be harvested but there is a lack of comprehensive biological data for many of these species, particularly important life history characteristics. This study addresses this knowledge gap by assessing 2621 individual length–weight relationships of key-target sea cucumber species associated with the fishery across the range of the distribution of the species and covering a variety of habitats, depths, sampling times, and management zones. Linear models with log transformations were used to analyse the relationships between length and weight. Results revealed significant positive relationships for all assessed species, with Holothuria atra having the clearest relationship between length and weight (R² = 0.45). Only negative allometric relationships were observed, as is the case for many species of holothurians. Despite challenges associated with measuring and weighing these soft and elastic animals, results will be useful for understanding length–weight dynamics across species. This research underscores the importance of robust biological data for the effective management of sea cucumber fisheries and ultimately reef health. Full article

Tropical ferns are underrepresented in demographic studies, despite their ecological importance in forest ecosystems. This study investigates the mortality rates of terrestrial ferns along an elevational gradient (500–4000 m a.s.l.) in Ecuador, focusing on relationships with environmental variables, community characteristics, and plant size. Over two years (2009–2011), 3213 individuals representing 88 species were monitored in 22 permanent plots across eight elevations. Mortality rates, calculated as the percentage of individuals lost annually, averaged 0.87%, with a hump-shaped trend along the gradient and a significant negative relationship with temperature. Mortality rates were positively correlated with species richness and fern density, suggesting competition may influence community structure. Larger individuals exhibited higher mortality rates, likely due to greater resource demands and exposure to environmental stressors. These findings emphasize the interplay of abiotic factors, such as elevation and temperature, and biotic interactions, including competition and herbivory, in shaping fern population dynamics. The low mortality rates observed reflect population stability, potentially linked to unique life history traits, such as extended generation times. This study provides critical insights into the demographic strategies of tropical ferns and underscores the need for long-term research to better understand their responses to environmental and biotic pressures. Full article

Different life histories result in different strategies to allocate energy in biosynthesis, including growth and reproduction, and somatic maintenance. One of the most notable life history differences between Lepidoptera and Blattodea species is that the former grow much faster than the latter, and during metamorphosis, a large amount of tissue in Lepidoptera species disintegrates. In this review, using Lepidoptera caterpillars and cockroach nymphs as examples, we show that, due to these differences in growth processes, cockroach nymphs spend 20 times more energy on synthesizing one unit of biomass (indirect cost of growth) than butterfly caterpillars. Because of the low indirect cost of growth in caterpillars, the fraction of metabolic energy allocated to growth is six times lower, and that for maintenance is seven times higher in caterpillars, compared to cockroach nymphs, despite caterpillar’s higher growth rates. Moreover, due to the higher biosynthetic energy cost in cockroach nymphs, they have better cellular qualities, including higher proteasomal activity for protein quality control and higher resistance to oxidative stress. We also show that under food restriction conditions, the fraction of assimilated energy allocated to growth was reduced by 120% in cockroach nymphs, as they lost body weight under food restriction, while this reduction was only 14% in hornworms, and the body mass increased at a lower rate. Finaly, we discuss future research, especially the difference in adult lifespans associated with the energetic differences. Full article

Since its inception, the theory of urban image cognition has become one of the most important theoretical frameworks in the field of urban planning and design. It emphasizes people’s subjective perception and cognition of the urban environment, and states that the city is not only a collection of material space but also a place with a specific meaning and image in people’s minds. This study explored the history and current situation of the Hubei Institute of Fine Arts (HIFA) campus and analyzed six aspects based on urban image theory: road imagery characteristics, boundary imagery characteristics, node imagery characteristics, the imagery characteristics of landmarks, the imagery characteristics of buildings, and the imagery characteristics of regions. We then summarized its existing spatial layout, architectural features, and cultural elements. The researchers employed three methodologies—the investigation of historical archives, the field survey method, and a technique that combines cognitive mapping with questionnaire surveys—to assess the strengths and shortcomings of existing campuses regarding the urban image theory. These findings resulted in the concept for an extensive renewal design plan that integrates the cognitive principles of urban imagery. The strategies included the following: (1) optimizing the spatial structure to enhance the connectivity and visibility of the campus; (2) renovating and upgrading existing buildings to reflect the artistic characteristics of the HIFA; and (3) designing unique landscapes and public spaces to create a rich and vibrant campus atmosphere. At the same time, researchers and design teams carried out design practice projects for four sub-projects on the HIFA campus: Aesthetic Education Avenue, Long Scroll by the Lake, Nine-Curved Corridor Bridge, and Open Campus–Urban Life Plaza. Through a case study of the HIFA, this research aims to provide a valuable reference for the campus renewal of other art universities, and to promote the application and innovation of urban image theory in the field of campus planning and design. It ultimately emphasizes the importance of creating a campus environment that not only meets the functional needs of education and research, but also enriches urban cultural imagery and enhances the sense of identity and belonging in the campus community. Full article

Moulting is a crucial yet challenging life-history trait to study in seabirds, particularly in the wild. Public aquariums offer valuable opportunities to collect detailed data, which, although not directly transferable to wild populations, provide important insights. At Oceanário de Lisboa, six Fratercula arctica individuals were monitored over seven years to document moulting patterns. The start and end of each moult were consistently recorded around the spring and autumn equinoxes. Pre-alternate moults lasted between 17 and 73 days, while pre-basic moults ranged from 11 to 48 days, with primary moults occurring between the two. This study is the first to document an asynchrony between the primary and the pre-alternate moults in F. arctica, highlighting a previously unreported aspect of the species’ moulting process. This seven-year time series and its findings prompt a call for action for further studies in controlled conditions, to investigate this pattern under different conditions and across puffins’ life stages. Such data could be crucial for developing more effective conservation strategies for this vulnerable species. These findings emphasize the importance of continued monitoring and research on ex situ puffin populations to expand our understanding of their moulting behaviour and its implications for wild populations. Full article

Food allergy represents a significant public health concern, with its prevalence increasing in recent decades. Tree nuts are among major allergenic foods, and allergies to them are frequently linked to severe and potentially life-threatening reactions. Data on the prevalence and natural history of tree nut allergy are limited. Primary nut allergy typically presents with rapid-onset IgE-mediated symptoms. Diagnosis can be confirmed by demonstrating a positive skin prick test (SPT), specific IgE (sIgE), or through an oral food challenge. Component-resolved diagnostics (CRD) can identify those with a high risk of anaphylaxis. The main management strategy involves avoiding the culprit allergen and treating symptoms after accidental exposure. New therapeutic options, such as sublingual immunotherapy, oral food immunotherapy, with or without omalizumab, and other monoclonal antibodies, are being investigated to modify tree nut allergy. Tree nut allergy is a lifelong disease with a low likelihood of resolution. The aim of this paper is to present the current data on the prevalence, diagnosis, natural history, and management options for tree nut allergy. Full article

Throughout history, humanity has grappled with infectious diseases that pose serious risks to health and life. The COVID-19 pandemic has profoundly impacted society, prompting significant reflection on preparedness and response strategies. In the future, humans may face unexpected disasters or crises, making it essential to learn from the COVID-19 experience, especially in ensuring adequate emergency supplies and mobilizing resources effectively in times of need. Efficient emergency medical management is crucial during sudden outbreaks, and the preparation and allocation of medical supplies are vital to safeguarding lives, health, and safety. However, the unpredictable nature of epidemics, coupled with population dynamics, means that infection rates and supply needs within affected areas are uncertain. By studying the factors and mechanisms influencing emergency supply demand during such events, materials can be distributed more efficiently to minimize harm. This study enhances the existing dynamics model of infectious disease outbreaks by establishing a demand forecasting model for emergency supplies, using Hubei Province in China as a case example. This model predicts the demand for items such as masks, respirators, and food in affected regions. Experimental results confirm the model’s effectiveness and reliability, providing support for the development of comprehensive emergency material management systems. Ultimately, this study offers a framework for emergency supply distribution and a valuable guideline for relief efforts. Full article