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12 pages, 1555 KiB  
Article
A Simple Mathematical Model to Predict the Pressure Drop for Transport of Deformable Particles in Homogeneous Porous Media
by Víctor Matías-Pérez, Simón López-Ramírez, Elizbeth Franco-Urresti and Carlos G. Aguilar-Madera
Viewed by 390
Abstract
The transport of deformable particles (TDPs) through porous media has been of considerable interest due to the multiple applications found in industrial and medical processes. The adequate design of these applications has been mainly achieved through experimental efforts, since TDPs through porous media [...] Read more.
The transport of deformable particles (TDPs) through porous media has been of considerable interest due to the multiple applications found in industrial and medical processes. The adequate design of these applications has been mainly achieved through experimental efforts, since TDPs through porous media are challenging to model because of the mechanical blockage of the pore throat due to size exclusion, deformation in order to pass through the pore throat under the driven pressure, and breakage under strong extrusion. In this work, based on the diffusivity equation and considering the TDP as a complex fluid whose viscosity and density depend on the local pressure, a simple but accurate theoretical model is proposed to describe the pressure behavior under steady- and unsteady-state flow conditions. Assuming a linear pressure dependence of the viscosity and density of the TDPs, valid for moderate pressure changes, the solution of the mathematical model yields a quantitative correlation between the pressure evolution and the parameters compressibility, viscosity coefficient, elastic modulus, particle size, and friction factor. The predictions of the model agree with experiments and allow the understanding of transport of deformable particles through a porous media. Full article
(This article belongs to the Special Issue Multiphase Flow for Industry Applications)
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19 pages, 1861 KiB  
Article
Analysing Flexural Response in RC Beams: A Closed-Form Solution Designer Perspective from Detailed to Simplified Modelling
by Denis Imamović and Matjaž Skrinar
Mathematics 2024, 12(21), 3327; https://doi.org/10.3390/math12213327 - 23 Oct 2024
Viewed by 851
Abstract
This paper presents a detailed analytical approach for the bending analysis of reinforced concrete beams, integrating both structural mechanics principles and Eurocode 2 provisions. The general analytical expressions derived for the curvature were applied for the transverse displacement analysis of a simply supported [...] Read more.
This paper presents a detailed analytical approach for the bending analysis of reinforced concrete beams, integrating both structural mechanics principles and Eurocode 2 provisions. The general analytical expressions derived for the curvature were applied for the transverse displacement analysis of a simply supported reinforced concrete beam under four-point loading, focusing on key limit states: the initiation of cracking, the yielding of tensile reinforcement and the compressive failure of concrete. The displacement’s results were validated through experimental testing, showing a high degree of accuracy in the elastic and crack propagation phases. Deviations in the yielding phase were attributed to the conservative material assumptions within the Eurocode 2 framework, though the analytical model remained reliable overall. To streamline the computational process for more complex structures, a simplified model utilising a non-linear rotational spring was further developed. This model effectively captures the influence of cracking with significantly reduced computational effort, making it suitable for serviceability limit state analyses in complex loading scenarios, such as seismic impacts. The results demonstrate that combining detailed analytical methods with this simplified model provides an efficient and practical solution for the analysis of reinforced concrete beams, balancing precision with computational efficiency. Full article
(This article belongs to the Special Issue Computational Mechanics and Applied Mathematics)
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20 pages, 8325 KiB  
Article
Response Surface Design Models to Predict the Strength of Iron Tailings Stabilized with an Alkali-Activated Cement
by Isabela Caetano, Sara Rios and Paula Milheiro-Oliveira
Appl. Sci. 2024, 14(18), 8116; https://doi.org/10.3390/app14188116 - 10 Sep 2024
Cited by 1 | Viewed by 646
Abstract
Tailing storage facilities are very complex structures whose failure generally leads to catastrophic consequences in terms of casualties, serious environmental impacts on local biodiversity, and disruptions in the mineral supply. For this reason, structures at risk must be reinforced or decommissioned. One possible [...] Read more.
Tailing storage facilities are very complex structures whose failure generally leads to catastrophic consequences in terms of casualties, serious environmental impacts on local biodiversity, and disruptions in the mineral supply. For this reason, structures at risk must be reinforced or decommissioned. One possible option is its reinforcement with compacted filtered tailings stabilized with binders. Alkali-activated binders provide a more sustainable solution than ordinary Portland cement but require an optimization of the tailing–binder mixture, which, in some cases, can lead to a substantial experimental effort. Statistical models have been used to reduce the number of those experiments, but a rational design methodology is still lacking. This methodology to define the right mixture for a required strength should consider both the mixture components and in situ conditions. In this paper, response surface methods were used to plan and interpret unconfined compression strength test results on an iron tailing stabilized with alkali-activated binders. It was concluded that the fly ash content was the most important parameter, followed by the liquid content and sodium hydroxide concentration. From the obtained results, several statistical models were defined and compared according to the definition of a strength prediction model based on a mixture index parameter. It was interesting to observe that models with the porosity cement index still provide reasonable adjustment even when different tailings’ water contents are considered. Full article
(This article belongs to the Special Issue Geotechnical Engineering: Principles and Applications)
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18 pages, 1709 KiB  
Article
Quantifying Lumbar Foraminal Volumetric Dimensions: Normative Data and Implications for Stenosis—Part 2 of a Comprehensive Series
by Renat Nurmukhametov, Manuel De Jesus Encarnacion Ramirez, Medet Dosanov, Abakirov Medetbek, Stepan Kudryakov, Laith Wisam Alsaed, Gennady Chmutin, Gervith Reyes Soto, Jeff Ntalaja Mukengeshay, Tshiunza Mpoyi Chérubin, Vladimir Nikolenko, Artem Gushcha, Sabino Luzzi, Andreina Rosario Rosario, Carlos Salvador Ovalle, Katherine Valenzuela Mateo, Jesus Lafuente Baraza, Juan Carlos Roa Montes de Oca, Carlos Castillo Rangel and Salman Sharif
Med. Sci. 2024, 12(3), 34; https://doi.org/10.3390/medsci12030034 - 22 Jul 2024
Cited by 2 | Viewed by 1635
Abstract
Introduction: Lumbar foraminal stenosis (LFS) occurs primarily due to degenerative changes in older adults, affecting the spinal foramina and leading to nerve compression. Characterized by pain, numbness, and muscle weakness, LFS arises from structural changes in discs, joints, and ligaments, further complicated by [...] Read more.
Introduction: Lumbar foraminal stenosis (LFS) occurs primarily due to degenerative changes in older adults, affecting the spinal foramina and leading to nerve compression. Characterized by pain, numbness, and muscle weakness, LFS arises from structural changes in discs, joints, and ligaments, further complicated by factors like inflammation and spondylolisthesis. Diagnosis combines patient history, physical examination, and imaging, while management ranges from conservative treatment to surgical intervention, underscoring the need for a tailored approach. Materials and Methods: This multicenter study, conducted over six years at a tertiary hospital, analyzed the volumetric dimensions of lumbar foramina and their correlation with nerve structures in 500 patients without lumbar pathology. Utilizing high-resolution MRI with a standardized imaging protocol, eight experienced researchers independently reviewed the images for accurate measurements. The study emphasized quality control through the calibration of measurement tools, double data entry, validation checks, and comprehensive training for researchers. To ensure reliability, interobserver and intraobserver agreements were analyzed, with statistical significance determined by kappa statistics and the Student’s t-test. Efforts to minimize bias included blinding observers to patient information and employing broad inclusion criteria to mitigate referral and selection biases. The methodology and findings aim to enhance the understanding of normal lumbar foramina anatomy and its implications for diagnosing and treating lumbar conditions. Results: The study’s volumetric analysis of lumbar foramina in 500 patients showed a progressive increase in foraminal volume from the L1/L2 to the L5/S1 levels, with significant enlargement at L5/S1 indicating anatomical and biomechanical complexity in the lumbar spine. Lateral asymmetry suggested further exploration. High interobserver and intraobserver agreement levels (ICC values of 0.91 and 0.95, respectively) demonstrated the reliability and reproducibility of measurements. The patient cohort comprised 58% males and 42% females, highlighting a balanced gender distribution. These findings underscore the importance of understanding foraminal volume variations for lumbar spinal health and pathology. Conclusion: Our study significantly advances spinal research by quantifying lumbar foraminal volumes, revealing a clear increase from the L1/L2 to the L5/S1 levels, indicative of the spine’s adaptation to biomechanical stresses. This provides clinicians with a precise tool to differentiate between pathological narrowing and normal variations, enhancing the detection and treatment of lumbar foraminal stenosis. Despite limitations like its cross-sectional design, the strong agreement in measurements underscores the method’s reliability, encouraging future research to further explore these findings’ clinical implications. Full article
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16 pages, 2681 KiB  
Article
Local and Global Context-Enhanced Lightweight CenterNet for PCB Surface Defect Detection
by Weixun Chen, Siming Meng and Xueping Wang
Sensors 2024, 24(14), 4729; https://doi.org/10.3390/s24144729 - 21 Jul 2024
Cited by 2 | Viewed by 1254
Abstract
Printed circuit board (PCB) surface defect detection is an essential part of the PCB manufacturing process. Currently, advanced CCD or CMOS sensors can capture high-resolution PCB images. However, the existing computer vision approaches for PCB surface defect detection require high computing effort, leading [...] Read more.
Printed circuit board (PCB) surface defect detection is an essential part of the PCB manufacturing process. Currently, advanced CCD or CMOS sensors can capture high-resolution PCB images. However, the existing computer vision approaches for PCB surface defect detection require high computing effort, leading to insufficient efficiency. To this end, this article proposes a local and global context-enhanced lightweight CenterNet (LGCL-CenterNet) to detect PCB surface defects in real time. Specifically, we propose a two-branch lightweight vision transformer module with local and global attention, named LGT, as a complement to extract high-dimension features and leverage context-aware local enhancement after the backbone network. In the local branch, we utilize coordinate attention to aggregate more powerful features of PCB defects with different shapes. In the global branch, Bi-Level Routing Attention with pooling is used to capture long-distance pixel interactions with limited computational cost. Furthermore, a Path Aggregation Network (PANet) feature fusion structure is incorporated to mitigate the loss of shallow features caused by the increase in model depth. Then, we design a lightweight prediction head by using depthwise separable convolutions, which further compresses the computational complexity and parameters while maintaining the detection capability of the model. In the experiment, the LGCL-CenterNet increased the [email protected] by 2% and 1.4%, respectively, in comparison to CenterNet-ResNet18 and YOLOv8s. Meanwhile, our approach requires fewer model parameters (0.542M) than existing techniques. The results show that the proposed method improves both detection accuracy and inference speed and indicate that the LGCL-CenterNet has better real-time performance and robustness. Full article
(This article belongs to the Section Sensing and Imaging)
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29 pages, 4441 KiB  
Article
Lean-and-Green Fractional Factorial Screening of 3D-Printed ABS Mechanical Properties Using a Gibbs Sampler and a Neutrosophic Profiler
by Tryfonas Pantas and George Besseris
Sustainability 2024, 16(14), 5998; https://doi.org/10.3390/su16145998 - 13 Jul 2024
Cited by 2 | Viewed by 1184
Abstract
The use of acrylonitrile butadiene styrene (ABS) in additive manufacturing applications constitutes an elucidating example of a promising match of a sustainable material to a sustainable production process. Lean-and-green datacentric-based techniques may enhance the sustainability of product-making and process-improvement efforts. The mechanical properties—the [...] Read more.
The use of acrylonitrile butadiene styrene (ABS) in additive manufacturing applications constitutes an elucidating example of a promising match of a sustainable material to a sustainable production process. Lean-and-green datacentric-based techniques may enhance the sustainability of product-making and process-improvement efforts. The mechanical properties—the yield strength and the ultimate compression strength—of 3D-printed ABS product specimens are profiled by considering as many as eleven controlling factors at the process/product design stage. A fractional-factorial trial planner is used to sustainably suppress by three orders of magnitude the experimental needs for materials, machine time, and work hours. A Gibbs sampler and a neutrosophic profiler are employed to treat the complex production process by taking into account potential data uncertainty complications due to multiple distributions and indeterminacy issues due to inconsistencies owing to mechanical testing conditions. The small-data multifactorial screening outcomes appeared to steadily converge to three factors (the layer height, the infill pattern angle, and the outline overlap) with a couple of extra factors (the number of top/bottom layers and the infill density) to supplement the linear modeling effort and provide adequate predictions for maximizing the responses of the two examined mechanical properties. The performance of the optimal 3D-printed ABS specimens exhibited sustainably acceptable discrepancies, which were estimated at 3.5% for the confirmed mean yield strength of 51.70 MPa and at 5.5% for the confirmed mean ultimate compression strength of 53.58 MPa. The verified predictors that were optimally determined from this study were (1) the layer thickness—set at 0.1 mm; (2) the infill angle—set at 0°; (3) the outline overlap—set at 80%; (4) the number of top/bottom layers—set at 5; and (5) the infill density—set at 100%. The multifactorial datacentric approach composed of a fractional-factorial trial planner, a Gibbs sampler, and a neutrosophic profiler may be further tested on more intricate materials and composites while introducing additional product/process characteristics. Full article
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14 pages, 5898 KiB  
Article
Theoretical and Experimental Verification of the Physical–Mechanical Properties of Organic Bone Meal Granular Fertilizers
by Eglė Jotautienė, Vaidas Bivainis, Davut Karayel and Ramūnas Mieldažys
Agronomy 2024, 14(6), 1171; https://doi.org/10.3390/agronomy14061171 - 30 May 2024
Viewed by 910
Abstract
Continuous efforts are being made to improve fertilizer efficiency by improving fertilizer technology, quality, and application rates. Granular organic fertilizers are more difficult to achieve uniform application because their physical–mechanical properties differ significantly from mineral fertilizers. The properties of granular organic fertilizers can [...] Read more.
Continuous efforts are being made to improve fertilizer efficiency by improving fertilizer technology, quality, and application rates. Granular organic fertilizers are more difficult to achieve uniform application because their physical–mechanical properties differ significantly from mineral fertilizers. The properties of granular organic fertilizers can best be determined experimentally. However, these studies are often quite complex. Modern engineering modeling software makes it possible to model the properties of granular fertilizers and their dispersion. This study deals with the theoretical and experimental verification of the physical–mechanical properties of organic bone meal granular fertilizer. For the verification of selected properties of bone meal granules, the following studies were carried out on the granules: determination of poured bulk density, static and dynamic angles of repose, static and dynamic friction coefficients of granule surface, etc. The results showed that for modeling fertilizer properties, it is sufficient to carry out a static compression test to determine the modulus of elasticity and a friction test between granules and the contacting surface to determine the static and dynamic friction coefficients. The remaining properties of the granules can be modeled and calibrated with the DEM software Altair EDEM 2023. Full article
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25 pages, 1117 KiB  
Article
An Exploratory Grounded Theory Approach: Unveiling the Impact Mechanism Model of Collaborative Dynamics between Green Production and Living
by Wenyue Ge, Jianguo Du and Kishwar Ali
Sustainability 2024, 16(8), 3352; https://doi.org/10.3390/su16083352 - 17 Apr 2024
Viewed by 1486
Abstract
In response to the intensifying compression of resources and the environment associated with rapid industrial growth and increasing living standards, green production and sustainable living have developed essential facts for ecologically conscious progress. Despite the potential benefits of synergy, the complex relationship between [...] Read more.
In response to the intensifying compression of resources and the environment associated with rapid industrial growth and increasing living standards, green production and sustainable living have developed essential facts for ecologically conscious progress. Despite the potential benefits of synergy, the complex relationship between green production and living organisms presents challenges that have not been thoroughly explored. This paper aims to fill this gap by proposing a comprehensive mechanism model that elucidates the collaboration between green production and life. Using comprehensive interviews and grounded theory procedures, this study, situated within the supply and demand context, precisely undoes the important basics and academic foundations of the synergy association between green production and living. The outcomes of this study disclose prominent insights: Firstly, collaborative perception, collective ability, and a cooperative atmosphere develop as substantial features with a significant effect on the synergy between green production and living, with resource environments having an indirect impact through their stimulus on synergy capacity. Secondly, the synergy efforts in green production and living, propelled by policy, social, and market environments, display characteristic features. Thirdly, the moderate perception of green production and living relationship is divided into the following four visible facets: educating a demand market for green supply, meeting green demand, catalyzing demand through green supply, and pushing supply through green demand. This paper proposes valuable recommendations, providing targeted policy designs and execution pathways for legislative entities looking for operative intercessions to adoptive collective activities in green production and living. Full article
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32 pages, 4475 KiB  
Article
The Efficiency of Using Machine Learning Techniques in Fiber-Reinforced-Polymer Applications in Structural Engineering
by Mohammad Alhusban, Mohannad Alhusban and Ayah A. Alkhawaldeh
Sustainability 2024, 16(1), 11; https://doi.org/10.3390/su16010011 - 19 Dec 2023
Cited by 2 | Viewed by 2064
Abstract
Sustainable solutions in the building construction industry have emerged as a new method for retrofitting applications in the last two decades. Fiber-reinforced polymers (FRPs) have garnered much attention among researchers for improving reinforced concrete (RC) structures. The existing design guidelines for FRP-strengthened RC [...] Read more.
Sustainable solutions in the building construction industry have emerged as a new method for retrofitting applications in the last two decades. Fiber-reinforced polymers (FRPs) have garnered much attention among researchers for improving reinforced concrete (RC) structures. The existing design guidelines for FRP-strengthened RC members were developed using empirical methods that are based on specific databases, limiting the accuracy of the predicted results. Therefore, the use of innovative and efficient prediction tools to predict the behavior of FRP-strengthened RC members has become essential. During the last few years, efforts have been progressively focused on the use of machine learning (ML) as a feasible and effective technique for solving various structural engineering problems. Its capability to predict the behavior of complex nonlinear structural systems while considering a wide range of parameters offers a distinctive opportunity to make the behavior of RC members more predictable and accurate. This paper aims to evaluate the current state of using various ML algorithms in RC members strengthened with FRP to enable researchers to determine the capabilities of current solutions as well as to find research gaps to carry out more research to bridge revealed knowledge and practice gaps. Scopus databases were searched using predefined standards. The search revealed ninety-six articles published between 2016 and 2023. Consequently, these articles were analyzed for ML applications in the field of FRP retrofitting, including flexural and shear strengthening of RC beams, flexural strengthening of slabs, confinement and compressive strength of columns, and FRP bond strength. The results reveal that 32% of the reviewed studies focused on the application of ML techniques to the flexural and shear strengthening of RC beams, 32% on the confinement and compressive strength of columns, 6.5% on the flexural strengthening of slabs, 22% on FRP bond strength, 6.5% on materials, and 1% on beam–column joints. This research also revealed that the application of various ML algorithms has shown a significant improvement in resistance prediction accuracy as compared with the existing empirical solutions. Supervised learning techniques were the most favorable learning method due to their good generalization, interpretability, adaptability, and predictive efficiency. In addition, the selection of suitable ML algorithms and optimization techniques is found to be mainly dictated by the nature of the problem and the characteristics of the dataset. Nonetheless, selecting the most appropriate ML model and optimization algorithm for each specific application remains a challenge, given that each algorithm is developed with different principles and methodologies. Full article
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29 pages, 2842 KiB  
Review
Performance of Unreinforced Masonry Walls in Compression: A Review of Design Provisions, Experimental Research, and Future Needs
by Abrahem A. Ali Blash, B. H. Abu Bakar, Ufuoma Joseph Udi, Bassam S. A. Dabbour, Azhar Ayad Jaafar, Li Yanhao, Ilyani Akmar Abu Bakar and Majed Rashed
Appl. Sci. 2023, 13(22), 12306; https://doi.org/10.3390/app132212306 - 14 Nov 2023
Cited by 6 | Viewed by 3090
Abstract
Unreinforced masonry (URM) is a construction of brick or concrete block unit that is joined together using mortar, without steel reinforcement. Because of the heterogeneous nature and difference in mechanical properties of the masonry elements, analyzing and capturing the structural behaviour of URM [...] Read more.
Unreinforced masonry (URM) is a construction of brick or concrete block unit that is joined together using mortar, without steel reinforcement. Because of the heterogeneous nature and difference in mechanical properties of the masonry elements, analyzing and capturing the structural behaviour of URM walls under various loading conditions is therefore complex. In recent decades, research efforts have been focused on addressing and understanding the compressive behaviour of URM walls from the experimental viewpoint. However, from the existing experimental literature, there is a significant degree of variation in the mechanical and geometric properties of URM walls, especially the comprehensive comparison of apparently equivalent test parameters, which has yet to be examined. It is therefore necessary to highlight and critically examine major results derived from the experimental literature to better understand the performance of URM walls under compressive loads. This review paper presents the assessment performance with regard to axial compressive tests on URM walls, along with comprehensive comparisons among the experimental literature findings on the basis of masonry construction methods and various influencing parameters. Emphasis in the literature has been placed chiefly on the masonry elements, design provisions, axial load, slenderness ratio, openings, and stress–strain response. Based on observations from the study, experimental development trends have been highlighted to identify and outline potential directions for future studies. Full article
(This article belongs to the Special Issue Feature Review Papers in Civil Engineering)
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16 pages, 5872 KiB  
Article
A Micromechanical-Based Semi-Empirical Model for Predicting the Compressive Strength Degradation of Concrete under External Sulfate Attack
by Shagang Li, Xiaotong Yu, Shanyin Yang, Hongxiang Wang and Da Chen
Materials 2023, 16(16), 5542; https://doi.org/10.3390/ma16165542 - 9 Aug 2023
Cited by 2 | Viewed by 1295
Abstract
As one of the most harmful ions in the environment, sulfate could cause the deformation and material deterioration of concrete structures. Models that accurately describe the whole chemo–transport–mechanical process of an external sulfate attack (ESA) require substantial computational work and contain complex parameters. [...] Read more.
As one of the most harmful ions in the environment, sulfate could cause the deformation and material deterioration of concrete structures. Models that accurately describe the whole chemo–transport–mechanical process of an external sulfate attack (ESA) require substantial computational work and contain complex parameters. This paper proposes a semi-empirical model based on micromechanical theory for predicting the compressive strength degradation of concrete under an ESA with basic properties of the undamaged material and limited computational effort. A simplified exponential function is developed for the total amount of the invading sulfate, and a second-order equation governs the chemical reaction. A micromechanical model is implemented to solve the mechanical response caused by an ESA. The model is able to describe the compressive stress–strain behavior of concrete subject to uniaxial loading in good agreement with the experimental results. For the case of a sulfate-attacked material, the relationship between compressive strength and expansion is calculated and validated by the test results. Finally, the deterioration process of compressive strength is predicted with the test results of deformation. Full article
(This article belongs to the Special Issue Mechanical Behaviors of Materials: Modelling and Measurement)
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17 pages, 4108 KiB  
Article
Advanced Tree-Based Techniques for Predicting Unconfined Compressive Strength of Rock Material Employing Non-Destructive and Petrographic Tests
by Yuzhen Wang, Mahdi Hasanipanah, Ahmad Safuan A. Rashid, Binh Nguyen Le and Dmitrii Vladimirovich Ulrikh
Materials 2023, 16(10), 3731; https://doi.org/10.3390/ma16103731 - 15 May 2023
Cited by 13 | Viewed by 1703
Abstract
The accurate estimation of rock strength is an essential task in almost all rock-based projects, such as tunnelling and excavation. Numerous efforts to create indirect techniques for calculating unconfined compressive strength (UCS) have been attempted. This is often due to the complexity of [...] Read more.
The accurate estimation of rock strength is an essential task in almost all rock-based projects, such as tunnelling and excavation. Numerous efforts to create indirect techniques for calculating unconfined compressive strength (UCS) have been attempted. This is often due to the complexity of collecting and completing the abovementioned lab tests. This study applied two advanced machine learning techniques, including the extreme gradient boosting trees and random forest, for predicting the UCS based on non-destructive tests and petrographic studies. Before applying these models, a feature selection was conducted using a Pearson’s Chi-Square test. This technique selected the following inputs for the development of the gradient boosting tree (XGBT) and random forest (RF) models: dry density and ultrasonic velocity as non-destructive tests, and mica, quartz, and plagioclase as petrographic results. In addition to XGBT and RF models, some empirical equations and two single decision trees (DTs) were developed to predict UCS values. The results of this study showed that the XGBT model outperforms the RF for UCS prediction in terms of both system accuracy and error. The linear correlation of XGBT was 0.994, and its mean absolute error was 0.113. In addition, the XGBT model outperformed single DTs and empirical equations. The XGBT and RF models also outperformed KNN (R = 0.708), ANN (R = 0.625), and SVM (R = 0.816) models. The findings of this study imply that the XGBT and RF can be employed efficiently for predicting the UCS values. Full article
(This article belongs to the Section Materials Simulation and Design)
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29 pages, 440 KiB  
Review
Assessment of Existing Fate and Transport Models for Predicting Antibiotic Degradation and Transport in the Aquatic Environment: A Review
by Temesgen Zelalem Addis, Joy Tuoyo Adu, Muthukrishnavellaisamy Kumarasamy and Molla Demlie
Water 2023, 15(8), 1511; https://doi.org/10.3390/w15081511 - 12 Apr 2023
Cited by 6 | Viewed by 3330
Abstract
In recent years, the use of antibiotics for human medicine, animal husbandry, agriculture, aquaculture, and product preservation has become a common practice. The use and application of antibiotics leave significant residues in different forms, with the aquatic environment becoming the critical sink for [...] Read more.
In recent years, the use of antibiotics for human medicine, animal husbandry, agriculture, aquaculture, and product preservation has become a common practice. The use and application of antibiotics leave significant residues in different forms, with the aquatic environment becoming the critical sink for accumulating antibiotic residues. Numerous studies have been conducted to understand antibiotic removal and persistence in the aquatic environment. Nevertheless, there is still a huge knowledge gap on their complex interactions in the natural environment, their removal mechanism, and the monitoring of their fate in the environment. Water quality models are practical tools for simulating the fate and transport of pollutant mass in the aquatic environment. This paper reports an overview of the physical, chemical, and biological elimination mechanisms responsible for the degradation of antibiotics in natural surface water systems. It provides an in-depth review of commonly used quantitative fate models. An effort has been made to provide a compressive review of the modeling philosophy, mathematical nature, environmental applicability, parameter estimation, prediction efficiency, strength, and limitation of commonly used environmental antibiotic fate models. The study provides information linking paradigms of elimination kinetics and their simulation in the antibiotic fate models aiming at critical issues regarding current model development and future perspectives and to help users select appropriate models for practical water quality assessment and management. Full article
28 pages, 4013 KiB  
Article
Quality by Design-Based Development of Solid Self-Emulsifying Drug Delivery System (SEDDS) as a Potential Carrier for Oral Delivery of Lysozyme
by Merima Šahinović, Alharith Hassan, Katalin Kristó, Géza Regdon, Edina Vranić and Tamás Sovány
Pharmaceutics 2023, 15(3), 995; https://doi.org/10.3390/pharmaceutics15030995 - 20 Mar 2023
Cited by 6 | Viewed by 3979
Abstract
For many years, researchers have been making efforts to find a manufacturing technique, as well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their target site of action without impairing their biological activity. Due to the positive [...] Read more.
For many years, researchers have been making efforts to find a manufacturing technique, as well as a drug delivery system, that will allow for oral delivery of biopharmaceuticals to their target site of action without impairing their biological activity. Due to the positive in vivo outcomes of this formulation strategy, self-emulsifying drug delivery systems (SEDDSs) have been intensively studied in the last few years as a way of overcoming the different challenges associated with the oral delivery of macromolecules. The purpose of the present study was to examine the possibility of developing solid SEDDSs as potential carriers for the oral delivery of lysozyme (LYS) using the Quality by Design (QbD) concept. LYS was successfully ion paired with anionic surfactant, sodium dodecyl sulphate (SDS), and this complex was incorporated into a previously developed and optimized liquid SEDDS formulation comprising medium-chain triglycerides, polysorbate 80, and PEG 400. The final formulation of a liquid SEDDS carrying the LYS:SDS complex showed satisfactory in vitro characteristics as well as self-emulsifying properties (droplet size: 13.02 nm, PDI: 0.245, and zeta potential: −4.85 mV). The obtained nanoemulsions were robust to dilution in the different media and highly stable after 7 days, with a minor increase in droplet size (13.84 nm) and constant negative zeta potential (−0.49 mV). An optimized liquid SEDDS loaded with the LYS:SDS complex was further solidified into powders by adsorption onto a chosen solid carrier, followed by direct compression into self-emulsifying tablets. Solid SEDDS formulations also exhibited acceptable in vitro characteristics, while LYS preserved its therapeutic activity in all phases of the development process. On the basis of the results gathered, loading the hydrophobic ion pairs of therapeutic proteins and peptides to solid SEDDS may serve as a potential method for delivering biopharmaceuticals orally. Full article
(This article belongs to the Special Issue Aspects and Implementation of Pharmaceutical Quality by Design)
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15 pages, 898 KiB  
Article
SDAFA: Secure Data Aggregation in Fog-Assisted Smart Grid Environment
by Shruti, Shalli Rani, Aman Singh, Reem Alkanhel and Dina S. M. Hassan
Sustainability 2023, 15(6), 5071; https://doi.org/10.3390/su15065071 - 13 Mar 2023
Cited by 4 | Viewed by 1962
Abstract
The tremendous growth of about 8 billion devices connected to each other in various domains of Internet of Things (IoT)-based applications have attracted researchers from both industry and academia. IoT is a network of several devices connected with each other to provide sensing [...] Read more.
The tremendous growth of about 8 billion devices connected to each other in various domains of Internet of Things (IoT)-based applications have attracted researchers from both industry and academia. IoT is a network of several devices connected with each other to provide sensing capabilities, particularly in smart grid (SG) environment. Various challenges such as the efficient handling of massive IoT data can be addressed with advances in fog computing. The secure data aggregation challenge is one such issue in IoT-based smart grid systems, which include millions of smart meters. Typical SG-based data aggregation approaches have high computation and communication costs, however, many efforts have been made to overcome these limitations while leveraging fog computing but no satisfactory results have been obtained. Moreover, existing solutions also suffer from high storage requirements. The traditional data aggregation schemes such as GCEDA (Grouping of Clusters for Efficient Data Aggregation) and SPPDA (Secure Privacy-Preserving Data Aggregation) also suffer from a few shortcomings. SPPDA follows a mixed aggregation architecture that includes trees and clusters which can lead to some performance complexities and is not energy-efficient, whereas GCEDA does not support heterogeneity. To overcome these problems, this research provides a fog-assisted strategy for secure and efficient data aggregation in smart grid. The concept of smart grid is implemented in fog environment, which was not the case in previous schemes. We used communication between smart meters (SMs) and fog nodes (FNs) to transmit confidential data in compressed form towards FN. The FN further aggregates the received data which can then be updated in cloud repositories later. We presented two algorithms—data aggregation and data extraction at FN and cloud, respectively, to achieve secure communication. The performance of the proposed strategy has been evaluated against existing data aggregation techniques GCEDA and SPPDA for various performance parameters such as storage, communication cost and transmission cost. The proposed scheme overcomes the limitation of heterogeneity and mixed aggregation which was faced in GCEDA and SPPDA and the results revealed outstanding performance in comparison with both, so the proposed solution can be used in a smart grid environment for efficient and secure data transmission. Full article
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