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Search Results (745)

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15 pages, 5913 KiB  
Article
Research on Self-Excited Inverter Rectification Method of Receiver in Wireless Power Transfer System
by Suqi Liu, Xueying Yan, Gang Wang and Yuping Liu
Processes 2025, 13(1), 89; https://doi.org/10.3390/pr13010089 - 2 Jan 2025
Viewed by 325
Abstract
To decrease the complexity and increase the efficiency of wireless power transfer (WPT) systems, this paper proposes a novel self-excited invert rectification method for the design of the invert rectifier of the receiver (Rx). The self-excited invert rectifier can perform the self-driving and [...] Read more.
To decrease the complexity and increase the efficiency of wireless power transfer (WPT) systems, this paper proposes a novel self-excited invert rectification method for the design of the invert rectifier of the receiver (Rx). The self-excited invert rectifier can perform the self-driving and soft-switching of the MOSFETs as well as the frequency-tracking function without a microcontroller. This allows us to greatly simplify the structure of the invert rectifier and increase the transfer efficiency (TE) of the WPT system. Firstly, a self-excited invert rectifier circuit is designed, and a self-excited invert rectification method is studied. Additionally, the power loss of the self-excited invert rectifier is analyzed. Finally, the self-excited invert rectifier of the WPT experimental system is designed. The self-excited invert rectification method is then verified. The key component parameters of the self-excited invert rectifier are provided and optimized. The TE of the WPT system that includes the self-excited invert rectifier is improved by more than 5% without a microcontroller. The self-excited invert rectifier of the Rx provides a practical solution for decreasing the complexity and increasing the TE of the WPT system. Full article
(This article belongs to the Section Energy Systems)
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14 pages, 13798 KiB  
Article
An Unenclosed Quasi-Static Cavity Resonator-Based Ubiquitous 3-D Wireless Power Transfer System Supporting Simultaneous Through-Wall Wireless Communications
by Qiaoli Zhang, Lingao Fan, Fangcheng Ren, Zhen Yue, Deshuang Zhao, Shuai Ding and Bingzhong Wang
Micromachines 2025, 16(1), 13; https://doi.org/10.3390/mi16010013 - 26 Dec 2024
Viewed by 323
Abstract
With the emergence of the Internet of Things (IoT), the demand on the wireless power supply to consumer electronics simultaneously requires much more location freedom, ease of use, and performance with wireless communications. In this paper, an unenclosed quasi-static cavity resonator (QSCR) constructed [...] Read more.
With the emergence of the Internet of Things (IoT), the demand on the wireless power supply to consumer electronics simultaneously requires much more location freedom, ease of use, and performance with wireless communications. In this paper, an unenclosed quasi-static cavity resonator (QSCR) constructed with metallic strips and the design method are proposed and theoretically analyzed. This unenclosed QSCR has a simple structure, which benefits the wireless charging for portable/wearable electronics and smart appliances in the office and home environment. Meanwhile, it can achieve simultaneous ubiquitous 3-dimensional (3-D) wireless power transfer (WPT) inside the cavity and through-wall wireless communications with external electronic devices. Simulation and experimentation are performed to verify the theoretical analysis of the proposed cavity resonator and the WPT system based on it. As demonstrated, at a powering frequency of 6.78 MHz, the unenclosed QSCR can wirelessly transfer power to the receivers with a maximum power transfer efficiency of 90.5%, and an efficiency exceeding 51.5% is obtained at almost any position within the cavity space. The measured through-wall wireless communication channel attenuation introduced by the unenclosed QSCR is below 2.87 dB. By adjusting the inserted lumped capacitor value, the system can work at any desired frequency. Full article
(This article belongs to the Special Issue Self-Assembly Circuits and Systems for Wireless Applications)
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27 pages, 6978 KiB  
Article
Tool Wear State Monitoring in Titanium Alloy Milling Based on Wavelet Packet and TTAO-CNN-BiLSTM-AM
by Zongshuo Yang, Li Li, Yunfeng Zhang, Zhengquan Jiang and Xuegang Liu
Processes 2025, 13(1), 13; https://doi.org/10.3390/pr13010013 - 24 Dec 2024
Viewed by 420
Abstract
To effectively monitor the nonlinear wear variation of tools during the processing of titanium alloys, this study proposes a hybrid deep neural network fault diagnosis model that integrates the triangulation topology aggregation optimizer (TTAO), convolutional neural network (CNN), bidirectional long short-term memory network [...] Read more.
To effectively monitor the nonlinear wear variation of tools during the processing of titanium alloys, this study proposes a hybrid deep neural network fault diagnosis model that integrates the triangulation topology aggregation optimizer (TTAO), convolutional neural network (CNN), bidirectional long short-term memory network (BiLSTM), and attention mechanism (AM). Firstly, vibration signals from the machine tool spindle are acquired and subjected to the wavelet packet transform (WPT) to extract multi-frequency band energy features as model inputs. Then, the CNN and BiLSTM modules capture the features and temporal relationships of the input signals. Finally, introduction of the AM, combined with the TTAO algorithm, automatically extracts deep features, overcoming issues such as local optima and slow convergence in traditional neural networks, thereby enhancing the accuracy and efficiency of tool wear state recognition. The experimental results demonstrate that the proposed model achieves an average accuracy rate of 98.649% in predicting tool wear states, outperforming traditional backpropagation (BP) networks and standard CNN models. Full article
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32 pages, 5801 KiB  
Review
Review on Development and Research of Underwater Capacitive Power Transfer
by Ying Liu, Binghe Li, Liangyi Pan, Shunyu Yao, Zhutao Dong, Jiantao Zhang, Chunbo Zhu and Shumei Cui
Energies 2024, 17(24), 6496; https://doi.org/10.3390/en17246496 - 23 Dec 2024
Viewed by 355
Abstract
Wireless power transfer (WPT) technology applied to underwater environments has the advantages of no electrical contact, high safety, and high applicability. Underwater capacitive power transfer (UCPT) technology shows great potential in the field of underwater wireless power transfer as it has more advantages [...] Read more.
Wireless power transfer (WPT) technology applied to underwater environments has the advantages of no electrical contact, high safety, and high applicability. Underwater capacitive power transfer (UCPT) technology shows great potential in the field of underwater wireless power transfer as it has more advantages compared to underwater inductive power transfer (UIPT) technology. This paper begins with the system principles of UCPT and explains the advantages of UCPT technology for underwater applications. It then reviews the coupler and equivalent circuit models currently used for UCPT in various underwater environments, which indicates the direction for the design of underwater couplers in the future. In addition, compensation networks currently applied in UCPT systems are summarized and compared. Furthermore, different application examples of UCPT are introduced, and the key factors constraining UCPT development are pointed out. Research directions for future development of UCPT technology are also investigated. Full article
(This article belongs to the Special Issue Energy, Electrical and Power Engineering: 3rd Edition)
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25 pages, 17981 KiB  
Article
Misalignment Tolerance Improvement of a Wireless Power Supply System for Drones Based on Transmitter Design with Multiple Annular-Sector-Shaped Coils
by Han Liu, Dengjie Huang, Lin Wang and Rong Wang
Viewed by 311
Abstract
The application of wireless power transfer (WPT) technology in power replenishment for drones can help to solve problems such as the frequent manual plugging and unplugging of cables. A wireless power replenishment system for drones based on the transmitter design with multiple annular-sector-shaped [...] Read more.
The application of wireless power transfer (WPT) technology in power replenishment for drones can help to solve problems such as the frequent manual plugging and unplugging of cables. A wireless power replenishment system for drones based on the transmitter design with multiple annular-sector-shaped coils is proposed in this paper, which improves the misalignment tolerance of couplers, enlarges the drone landing area, and reduces the control requirements of drone landing accuracy further. The general analysis model of the proposed transmitter and the numerical calculation method for mutual inductance between energy transceivers are established. Then, the effect of multiple parameters of the proposed transmitter on the variation in mutual inductance is studied. The misalignment tolerance improvement strategy based on the optimization of multiple parameters of the transmitter is investigated. Finally, an experimental prototype of a wireless power replenishment system for drones based on LCC-S compensation topology is designed to validate the theoretical research. Under the same maximum outer radius of 0.20 m and the same mutual inductance fluctuation rate of 5%, compared to single circular transmitter mode, the maximum offset distance of all directions (360 degrees) in the x-y plane is increased from 0.08 m to 0.12 m. As the receiving side position changes, the maximum receiving power and efficiency are 141.07 W and 93.79%, respectively. At the maximum offset position of 0.12 m, the received power and efficiency are still 132.13 W and 91.25%, respectively. Full article
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22 pages, 8086 KiB  
Article
Research on Structural Optimization and Excitation Control Method Using a Two-Dimensional OWPT System for Capsule Robots Based on Non-Equivalent Coils
by Wenwei Li, Pingping Jiang, Zhiwu Wang and Guozheng Yan
Micromachines 2024, 15(12), 1510; https://doi.org/10.3390/mi15121510 - 19 Dec 2024
Viewed by 396
Abstract
The rapid development of wireless power transfer (WPT) technology has provided new avenues for supplying continuous and stable power to capsule robots. In this article, we propose a two-dimensional omnidirectional wireless power transfer (OWPT) system, which enables power to be transmitted effectively in [...] Read more.
The rapid development of wireless power transfer (WPT) technology has provided new avenues for supplying continuous and stable power to capsule robots. In this article, we propose a two-dimensional omnidirectional wireless power transfer (OWPT) system, which enables power to be transmitted effectively in multiple spatial directions. This system features a three-dimensional transmitting structure with a Helmholtz coil and saddle coil pairs, combined with a one-dimensional receiving structure. This design provides sufficient internal space, accommodating patients of various body types. Based on the magnetic field calculation and finite element analysis, the saddle coil structure is optimized to enhance magnetic field uniformity; to achieve a two-dimensional rotating magnetic field, a phase difference control method for the excitation signal is developed through the analysis of circuit topology and quantitative synthesis of non-equivalent magnetic field vectors. Finally, an experimental prototype is built, and the experimental results show that the one-dimensional transmitting coil achieves a minimum received voltage stability of 94.5% across different positions. When the three-dimensional transmitting coils operate together, a two-dimensional rotating magnetic field in the plane is achieved at the origin, providing a minimum received power of 550 mW with a voltage fluctuation rate of 7.68%. Full article
(This article belongs to the Section B:Biology and Biomedicine)
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12 pages, 2805 KiB  
Communication
Berkeleyomyces rouxiae—A Pathogen Causing the Black Root Rot of Tobacco
by Grażyna Korbecka-Glinka, Anna Trojak-Goluch and Diana Czarnecka
Pathogens 2024, 13(12), 1120; https://doi.org/10.3390/pathogens13121120 - 18 Dec 2024
Viewed by 409
Abstract
Black root rot is a dangerous disease affecting many crops. It is caused by pathogens formerly known as Thielaviopsis basicola and then reclassified as two cryptic species, Berkeleyomyces basicola and B. rouxiae. The aim of this study was to perform species identification, [...] Read more.
Black root rot is a dangerous disease affecting many crops. It is caused by pathogens formerly known as Thielaviopsis basicola and then reclassified as two cryptic species, Berkeleyomyces basicola and B. rouxiae. The aim of this study was to perform species identification, morphological characterization, and pathogenicity tests for fungal isolates obtained from tobacco roots with black root rot symptoms in Poland. DNA sequences of the three regions (ITS, ACT, MCM7) were highly similar to the sequences of B. rouxiae deposited in the NCBI database. Phylogenetic analysis confirmed the assignment of the obtained isolates to this species. The cultures of four representative isolates (namely OT2, OT3, WPT7, WPT8) showed a similar structure and gray/brown color of the mycelium, although their growth rate varied from 3.8 to 5.1 mm/day depending on the isolate. The sizes of the endoconidia and chlamydospores showed a considerable variation, although they fit within ranges previously described for B. rouxiae. Pathogenicity tests performed on young tobacco plants grown in the inoculated peat substrate revealed differences among the four isolates. WPT7 demonstrated the lowest level of aggressiveness for tobacco. In contrast, the remaining three isolates caused severe disease symptoms and significantly reduced shoot and root dry weights of the susceptible cultivar Virginia Joyner. A parallel pathogenicity test performed on cultivar VRG 10TL confirmed the effectiveness of black root rot resistance derived from Nicotiana debneyi. Full article
(This article belongs to the Special Issue Advanced Research on Soil-Borne Diseases)
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32 pages, 12646 KiB  
Article
Model Decomposition-Based Approach to Optimizing the Efficiency of Wireless Power Transfer Inside a Metal Enclosure
by Romans Kusnins, Sergejs Tjukovs, Janis Eidaks, Kristaps Gailis and Dmitrijs Pikulins
Appl. Sci. 2024, 14(24), 11733; https://doi.org/10.3390/app142411733 - 16 Dec 2024
Viewed by 450
Abstract
This paper describes a numerically efficient method for optimizing the high power transfer efficiency (PTE) of a resonant cavity-based Wireless Power Transfer (WPT) system for the wireless charging of smart clothing. The WPT system under study unitizes a carbon steel closet intended to [...] Read more.
This paper describes a numerically efficient method for optimizing the high power transfer efficiency (PTE) of a resonant cavity-based Wireless Power Transfer (WPT) system for the wireless charging of smart clothing. The WPT system under study unitizes a carbon steel closet intended to store smart clothing overnight as a resonant cavity. The WPT system is designed to operate at 865.5 MHz; however, the operating frequency can be adjusted over a wide range. The main reason behind choosing a resonant cavity-based WPT system is that it has several advantages over the competitive WPT methods. Specifically, in contrast to its Far-field Power Transfer (FPT) and Inductive Power Transfer (IPT) counterparts, resonant cavity-based WPTs do not exhibit path loss and significant PTE sensitivity to the distance between the Tx and Rx coils and misalignment, respectively. The non-uniformity of the fields within the closet is addressed by using an optimized Yagi-like transmitting antenna with an additional element affecting the waveguide mode phases. The changes in the mode phases increase the volume inside the cavity, where the PTE values are higher than 50% (the high PTE region). In the present study, the model decomposition method is adapted to substantially accelerate the process of finding the optimal WPT system parameters. Additionally, the decomposition method explains the mechanism responsible for extending the high PTE region. The generalized scattering matrices are computed using the full-wave simulator Ansys HFSS for three sub-models. Then, the calculated S matrices are combined to evaluate the system’s PTE. The decomposition method is validated against full-wave simulations of the original WPT system’s model for several different parameter value combinations. The simulated results obtained for a sub-optimal model are experimentally verified by measuring the PTE of a real-life closet-based WPT system. The measured and calculated results are found to be in close agreement with the maximum measured PTE, as high as 60%. Full article
(This article belongs to the Section Energy Science and Technology)
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17 pages, 7592 KiB  
Article
Parametric Design Approach for Wireless Power Transfer System: UAV Applications
by Mohammed Terrah, Mostafa-Kamel Smail, Lionel Pichon and Mohamed Bensetti
Viewed by 758
Abstract
Adopting Wireless Power Transfer (WPT) technology to an Unmanned Aerial Vehicle (UAV) involves adding extra components, which may impact the drone’s overall weight and performance. This paper aims to enhance UAV performance by designing a lightweight WPT system through a parametric design approach. [...] Read more.
Adopting Wireless Power Transfer (WPT) technology to an Unmanned Aerial Vehicle (UAV) involves adding extra components, which may impact the drone’s overall weight and performance. This paper aims to enhance UAV performance by designing a lightweight WPT system through a parametric design approach. This method explores novel perspectives by identifying the most suitable combination of parameters in terms of efficiency, weight, and feasibility. Various parameters such as the compensation topology, number of turns of coils, and frequency were studied. The system was analyzed through a coupled simulation approach, where electromagnetic modeling of the coupler using the finite element method (FEM) was combined with electrical circuit simulations, providing a more accurate assessment of the overall system efficiency and behavior considering variations in the coupling factor due to misalignment. A prototype of the resulting configuration was designed and tested experimentally versus misalignment at reduced power using a specific test bench. The results show a 70% efficiency level with SP compensation that was improved to 80% with SS compensation. Full article
(This article belongs to the Section Drone Design and Development)
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10 pages, 384 KiB  
Article
Analysis of the Parity-Time Symmetry Model in the Receiver-Based Wireless Power Transfer
by Xiaoxi Yan and Wen Yan
Energies 2024, 17(23), 6103; https://doi.org/10.3390/en17236103 - 4 Dec 2024
Viewed by 443
Abstract
Parity-time (PT) symmetry has made encouraging progress in wireless power transmission (WPT), exhibiting significant advantages in terms of system robustness and transmission efficiency. However, there are still challenges that need to be addressed, particularly when classical schemes operate at a fixed frequency in [...] Read more.
Parity-time (PT) symmetry has made encouraging progress in wireless power transmission (WPT), exhibiting significant advantages in terms of system robustness and transmission efficiency. However, there are still challenges that need to be addressed, particularly when classical schemes operate at a fixed frequency in the weak coupling region, where even minor changes in coupling strength can result in excessive current surges. This paper introduced a novel PT-symmetric WPT system featuring negative resistance constructed on the receiver side. We first established a theoretical framework for the classical two-coil PT-symmetric magnetically coupled resonant WPT system and subsequently extended it to incorporate the PT-symmetric WPT system with negative resistance on the receiver. This topological coil configuration facilitated stable power delivery over a broader range, with the capability of self-tuning frequency without requiring additional frequency modulation. This adaptability enabled the system to cater to diverse scenarios and opens up a novel avenue for practical applications of PT symmetry in WPT. Finally, we designed a 10 W prototype to demonstrate the effectiveness of our topology, and the experimental results aligned with our theoretical calculations, validating the feasibility and potential of our PT-symmetric WPT system. Full article
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19 pages, 1177 KiB  
Article
Joint Divergence Angle of Free Space Optics (FSO) Link and UAV Trajectory Design in FSO-Based UAV-Enabled Wireless Power Transfer Relay Systems
by Jinho Kang
Photonics 2024, 11(12), 1136; https://doi.org/10.3390/photonics11121136 - 2 Dec 2024
Viewed by 659
Abstract
Free Space Optics (FSO)-based UAV-enabled wireless power transfer (WPT) relay systems have emerged as a key technology for 6G networks, efficiently providing continuous power to Internet of Things (IoT) devices even in remote areas such as disaster recovery zones, maritime regions, and military [...] Read more.
Free Space Optics (FSO)-based UAV-enabled wireless power transfer (WPT) relay systems have emerged as a key technology for 6G networks, efficiently providing continuous power to Internet of Things (IoT) devices even in remote areas such as disaster recovery zones, maritime regions, and military networks, while addressing the limited battery capacity of UAVs through the FSO fronthaul link. However, the harvested power at the ground devices depends on the displacement and diameter of the FSO beam spot reaching the UAV, as well as the UAV trajectory, which affects both the FSO link and the radio-frequency (RF) link simultaneously. In this paper, we propose a joint design of the divergence angle in the FSO link and the UAV trajectory, in order to maximize the power transfer efficiency. Driven by the analysis of the optimal condition for the divergence angle, we develop a hybrid BS-PSO-based method to jointly optimize them while improving optimization performance. Numerical results demonstrate that the proposed method substantially increases power transfer efficiency and improves the optimization capability. Full article
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46 pages, 17664 KiB  
Review
A Review of Research on Dual-Side Control Methods for Magnetic Coupling Wireless Power Transfer Systems Based on Dual-Active Bridge Converters
by Yanwei Jiang, Yingao Li, Jingjing Yang and Xujian Shu
Electronics 2024, 13(23), 4765; https://doi.org/10.3390/electronics13234765 - 2 Dec 2024
Viewed by 460
Abstract
Magnetic Coupling Wireless Power Transfer (MCWPT) technology has broad application prospects due to its high degree of freedom in energy exchange and unparalleled security. In recent years, various controllers have been added to WPT systems to improve energy transfer performance. Among them, the [...] Read more.
Magnetic Coupling Wireless Power Transfer (MCWPT) technology has broad application prospects due to its high degree of freedom in energy exchange and unparalleled security. In recent years, various controllers have been added to WPT systems to improve energy transfer performance. Among them, the Dual-Side Control (DSC) approach, which employs Dual-Active Bridge (DAB) converters with simultaneous control of the transmitter and receiver, has made great progress. The DAB structure has a compromise between cost and complexity, and the DSC can bring a high enough degree of control freedom to the MCWPT system to easily achieve efficiency optimization and desired output characteristics. However, various DSC methods have different characteristics. Therefore, this paper reviews and summarizes the current research status of DSC methods based on the DAB converters in MCWPT systems. Wireless communication is one of the decisive factors in the design of a control strategy, which is categorized in this paper according to the main approaches used in all the papers. Various DSC strategies are described in detail and compared comprehensively according to the control variables and control objectives. This review will be highly beneficial to research entities and industry professionals as a ready reference for the control design in MCWPT. Full article
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22 pages, 1686 KiB  
Article
Optimizing Transmit Power for User-Cooperative Backscatter-Assisted NOMA-MEC: A Green IoT Perspective
by Huaiwen He, Chenghao Zhou, Feng Huang, Hong Shen and Yihong Yang
Electronics 2024, 13(23), 4678; https://doi.org/10.3390/electronics13234678 - 27 Nov 2024
Viewed by 430
Abstract
Non-orthogonal multiple access (NOMA) enables the parallel offloading of multiuser tasks, effectively enhancing throughput and reducing latency. Backscatter communication, which passively reflects radio frequency (RF) signals, improves energy efficiency and extends the operational lifespan of terminal devices. Both technologies are pivotal for the [...] Read more.
Non-orthogonal multiple access (NOMA) enables the parallel offloading of multiuser tasks, effectively enhancing throughput and reducing latency. Backscatter communication, which passively reflects radio frequency (RF) signals, improves energy efficiency and extends the operational lifespan of terminal devices. Both technologies are pivotal for the next generation of wireless networks. However, there is little research focusing on optimizing the transmit power in backscatter-assisted NOMA-MEC systems from a green IoT perspective. In this paper, we aim to minimize the transmit energy consumption of a Hybrid Access Point (HAP) while ensuring task deadlines are met. We consider the integration of Backscatter Communication (BackCom) and Active Transmission (AT), and leverage NOMA technology and user cooperation to mitigate the double near–far effect. Specifically, we formulate a transmit energy consumption minimization problem, accounting for task deadline constraints, task offloading decisions, transmit power allocation, and energy constraints. To tackle the non-convex optimization problem, we employ variable substitution and convex optimization theory to transform the original non-convex problem into a convex one, which is then efficiently solved. We deduce the semi-closed form expression of the optimal solution and propose an energy-efficient algorithm to minimize the transmit power of the entire wireless powered MEC. The extensive simulation results demonstrate that our proposed scheme significantly reduces the HAP transmit power by around 8% compared to existing schemes, validating the effectiveness of our approach. This study provides valuable insights for the design of green IoT systems by optimizing the transmit power in NOMA-MEC networks. Full article
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15 pages, 19644 KiB  
Article
A Receiver Position Estimation Method Based on LSTM for Multi-Transmitter Single-Receiver Wireless Power Transfer Systems
by Zhuoyue Dai, Yongmin Yang, Yanting Luo, Suiyu Chen and Zhilong Lin
Electronics 2024, 13(23), 4670; https://doi.org/10.3390/electronics13234670 - 26 Nov 2024
Viewed by 418
Abstract
The multi-transmitter single-receiver wireless power transfer (MTSR-WPT) system has good tolerance for coil misalignment because the magnetic fields generated by multiple transmitters can be shaped to adapt to position changes in the receiver coil. In order to achieve magnetic field shaping of the [...] Read more.
The multi-transmitter single-receiver wireless power transfer (MTSR-WPT) system has good tolerance for coil misalignment because the magnetic fields generated by multiple transmitters can be shaped to adapt to position changes in the receiver coil. In order to achieve magnetic field shaping of the MTSR-WPT system and increase power transfer efficiency, accurately estimating the position of the receiver coil is a key issue that needs to be addressed. In this article, a receiver position estimation method based on long short-term memory (LSTM) is proposed, which utilizes a data-driven approach to establish a neural network model. By learning the relationship between the measured time-series voltage data of the transmitter coils and the position of the receiver coil, the proposed model can achieve accurate position estimation of the receiver. Compared with previous works, the proposed method does not require communication between the transmitter and receiver, which is conducive to simplifying the system structure and reducing costs. In addition, the proposed LSTM-based method requires less derivation of complex formulas and the internal mechanism analysis of the system. Finally, a MTSR-WPT prototype is built to verify the proposed method. The experimental results show that the proposed LSTM-based method can achieve high-accuracy position estimation of the receiver. When the receiver moves within a range of 160 mm × 160 mm, the average error between the estimated receiver coil position using the proposed method and the actual receiver coil position is less than 2.40 mm. Full article
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33 pages, 8596 KiB  
Article
Design, Synthesis and Biological Exploration of Novel N-(9-Ethyl-9H-Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (Mpro), Spike Glycoprotein and RdRp
by Ameer Fawad Zahoor, Saba Munawar, Sajjad Ahmad, Fozia Iram, Muhammad Naveed Anjum, Samreen Gul Khan, Jamila Javid, Usman Nazeer and Mashooq Ahmad Bhat
Int. J. Mol. Sci. 2024, 25(23), 12708; https://doi.org/10.3390/ijms252312708 - 26 Nov 2024
Viewed by 488
Abstract
A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65–89%) via S-alkylation of benzofuran-based triazoles with 2-bromo-N-(9-ethyl-9H-carbazol-3-yl)acetamide. The inhibitory potency of the synthesized compounds against SARS-CoV-2 was evaluated by enacting molecular docking against [...] Read more.
A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65–89%) via S-alkylation of benzofuran-based triazoles with 2-bromo-N-(9-ethyl-9H-carbazol-3-yl)acetamide. The inhibitory potency of the synthesized compounds against SARS-CoV-2 was evaluated by enacting molecular docking against its three pivotal proteins, namely, Mpro (main protease; PDB ID: 6LU7), the spike glycoprotein (PDB ID: 6WPT), and RdRp (RNA-dependent RNA polymerase; PDB ID: 6M71). The docking results indicated strong binding affinities between SARS-CoV-2 proteins and the synthesized compounds, which were thereby expected to obstruct the function of SARS proteins. Among the synthesized derivatives, the compounds 9e, 9h, 9i, and 9j exposited the best binding scores of −8.77, −8.76, −8.87, and −8.85 Kcal/mol against Mpro, respectively, −6.69, −6.54, −6.44, and −6.56 Kcal/mol against the spike glycoprotein, respectively, and −7.61, −8.10, −8.01, and −7.54 Kcal/mol against RdRp, respectively. Furthermore, the binding scores of 9b (−8.83 Kcal/mol) and 9c (−8.92 Kcal/mol) against 6LU7 are worth mentioning. Regarding the spike glycoprotein, 9b, 9d, and 9f expressed high binding energies of −6.43, −6.38, and −6.41 Kcal/mol, accordingly. Correspondingly, the binding affinity of 9g (−7.62 Kcal/mol) against RdRp is also noteworthy. Furthermore, the potent compounds were also subjected to ADMET analysis to evaluate their pharmacokinetic properties, suggesting that the compounds 9e, 9h, 9i, and 9j exhibited comparable values. These potent compounds may be selected as inhibitory agents and provide a pertinent context for further investigations. Full article
(This article belongs to the Section Biochemistry)
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