3D-Printed Polymers for Tissue Engineering or Bioelectronics

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 3318

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
Interests: 3D bioprinting; regenerative medicine; cardiac tissue engineering; bioelectronic

E-Mail Website1 Website2
Guest Editor
Thrust of Smart Manufacturing, Hong Kong University of Science and Technology (Guangzhou), Guangzhou 510230, China
Interests: fiber printing; bioelectronics; additive manufacturing; wearable technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymers, which serve as versatile matrices and frameworks, are pivotal in the realm of 3D-printed artificial tissues and bioelectronics. This Special Issue, “3D-Printed Polymers for Tissue Engineering or Bioelectronics”, is dedicated to cutting-edge research on polymer-based materials being developed in these forward-looking fields. We welcome studies that enhance tissue engineering through innovative polymer bioinks and advanced 3D printing techniques, addressing challenges such as biomimicry and vascularization. We also invite manuscripts on functional polymers that advance the sensing capability and biocompatible integration of bioelectronic devices. Contributions may address a range of topics, from the synthesis of novel polymers and refinement of 3D bioprinting techniques for complex tissue constructs to the application of functional polymers in biosensors and electronic skins. Here are some examples of relevant topics:

  • Development of novel polymers, biomaterials, and bioinks for tissue engineering and bioelectronics applications;
  • Innovation in 3D bioprinting and other biofabrication technologies;
  • Organ-on-a-chip, drug screening, and disease modeling;
  • Tissue engineering, organoids, and organ regeneration;
  • Wearable and implantable bioelectronic devices including biosensors, wearable devices, electroceuticals, and electronic skins;
  • Bioadhesives and wound healing.
We look forward to receiving your submission.

Dr. Yongcong Fang
Dr. Wenyu Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D bioprinting
  • flexible electronics
  • tissue engineering
  • biofabrication
  • wearable devices
  • regenerative medicine
  • organoids

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 5139 KiB  
Article
Evaluation of Additives on the Cell Metabolic Activity of New PHB/PLA-Based Formulations by Means of Material Extrusion 3D Printing for Scaffold Applications
by Ivan Dominguez-Candela, Lluc Sempere-José, Ignacio Sandoval-Perez and Asunción Martínez-García
Polymers 2024, 16(19), 2784; https://doi.org/10.3390/polym16192784 - 30 Sep 2024
Viewed by 1180
Abstract
In this study, specific additives were incorporated in polyhydroxyalcanoate (PHB) and polylactic acid (PLA) blend to improve its compatibility, and so enhance the cell metabolic activity of scaffolds for tissue engineering. The formulations were manufactured through material extrusion (MEX) additive manufacturing (AM) technology. [...] Read more.
In this study, specific additives were incorporated in polyhydroxyalcanoate (PHB) and polylactic acid (PLA) blend to improve its compatibility, and so enhance the cell metabolic activity of scaffolds for tissue engineering. The formulations were manufactured through material extrusion (MEX) additive manufacturing (AM) technology. As additives, petroleum-based poly(ethylene) with glicidyl metacrylate (EGM) and methyl acrylate-co-glycidyl methacrylate (EMAG); poly(styrene-co-maleic anhydride) copolymer (Xibond); and bio-based epoxidized linseed oil (ELO) were used. On one hand, standard geometries manufactured were assessed to evaluate the compatibilizing effect. The additives improved the compatibility of PHB/PLA blend, highlighting the effect of EMAG and ELO in ductile properties. The processability was also enhanced for the decrease in melt temperature as well as the improvement of thermal stability. On the other hand, manufactured scaffolds were evaluated for the purpose of bone regeneration. The mean pore size and porosity exhibited values between 675 and 718 μm and 50 and 53%, respectively. According to the results, the compression stress was higher (11–13 MPa) than the required for trabecular bones (5–10 MPa). The best results in cell metabolic activity were obtained by incorporating ELO and Xibond due to the decrease in water contact angle, showing a stable cell attachment after 7 days of culture as observed in SEM. Full article
(This article belongs to the Special Issue 3D-Printed Polymers for Tissue Engineering or Bioelectronics)
Show Figures

Figure 1

21 pages, 10317 KiB  
Article
Preparation and Structure–Property Relationship Study of Piezoelectric–Conductive Composite Polymer Nanofiber Materials for Bone Tissue Engineering
by Zhengyang Jin, Suiyan Wei, Wenyang Jin, Bingheng Lu and Yan Xu
Polymers 2024, 16(13), 1952; https://doi.org/10.3390/polym16131952 - 8 Jul 2024
Viewed by 1506
Abstract
This study aimed to develop Janus-, cross-network-, and coaxial-structured piezoelectric–conductive polymer nanofibers through electrospinning to mimic the piezoelectricity of bone and facilitate the conduction of electrical signals in bone tissue repair. These nanofibers were constructed using the piezoelectric polymer polyvinylidene fluoride, and the [...] Read more.
This study aimed to develop Janus-, cross-network-, and coaxial-structured piezoelectric–conductive polymer nanofibers through electrospinning to mimic the piezoelectricity of bone and facilitate the conduction of electrical signals in bone tissue repair. These nanofibers were constructed using the piezoelectric polymer polyvinylidene fluoride, and the conductive fillers reduced graphene oxide and polypyrrole. The influence of structural features on the electroactivity of the fibers was also explored. The morphology and components of the various structural samples were characterized using SEM, TEM, and FTIR. The electroactivity of the materials was assessed with a quasi-static d33 meter and the four-probe method. The results revealed that the piezoelectric–conductive phases were successfully integrated. The Janus-structured nanofibers demonstrated the best electroactivity, with a piezoelectric constant d33 of 24.5 pC/N and conductivity of 6.78 × 10−2 S/m. The tensile tests and MIP measurements showed that all samples had porosity levels exceeding 70%. The tensile strength of the Janus and cross-network structures exceeded that of the periosteum (3–4 MPa), with average pore sizes of 1194.36 and 2264.46 nm, respectively. These properties indicated good mechanical performance, allowing material support while preventing fibroblast invasion. The CCK-8 and ALP tests indicated that the Janus-structured samples were biocompatible and significantly promoted the proliferation of MC3T3-E1 cells. Full article
(This article belongs to the Special Issue 3D-Printed Polymers for Tissue Engineering or Bioelectronics)
Show Figures

Graphical abstract

Back to TopTop