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Volume 30
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Synthesis of (1,10-Phenanthroline-k2N,N′)(β2-Methyl- and β2-PhenylAlaninate-k2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines

by
Leticia Chavelas-Hernández
1,
Luis G. Hernández-Vázquez
1,*,
Jonathan R. Valdez-Camacho
1,2,
Adrián Espinoza-Guillén
3,
Carlos A. Tavira-Montalvan
4,
Angélica Meneses-Acosta
4,
Eusebio Juaristi
5,6,
Lena Ruiz-Azuara
3 and
Jaime Escalante
1,*
1
Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos. Av. Universidad 1001, Cuernavaca 62209, Mexico
2
Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Ciudad de México 09340, Mexico
3
Departamento de Química Inorgánica y Nuclear, Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Mexico City 04510, Mexico
4
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico
5
Departamento de Química, Centro de Investigación y de Estudios Avanzados, Avenida I.P.N. 2508, Ciudad de Mexico 07360, Mexico
6
El Colegio Nacional, Calle Luis González Obregón 23, Centro Histórico, Ciudad de Mexico 06020, Mexico
*
Authors to whom correspondence should be addressed.
Molecules 2025, 30(3), 634; https://doi.org/10.3390/molecules30030634 (registering DOI)
Submission received: 30 December 2024 / Revised: 23 January 2025 / Accepted: 23 January 2025 / Published: 31 January 2025
(This article belongs to the Special Issue Synthesis, Characterization and Application of Coordination Complexes)
Review Reports Versions Notes

Abstract

In recent years, metallodrugs have been playing an important role, showing to be more efficient in the treatment of several diseases, such as cancer. Indeed, it is important to synthesize novel molecules to be used as more effective agents against cancer. In the present paper, the synthesis of two new molecules belonging to Casiopeínas® is reported. These compounds present a β2-aminoacidate derivative as the secondary ligand. The novel metal complexes were characterized by high-resolution mass spectrometry, FT-IR, UV-Vis, EPR, effective magnetic moment and cyclic voltammetry measurements, and single crystal X-ray diffraction analysis. Furthermore, these compounds were evaluated in vitro against the cancer lines MCF-7 (breast cancer) and A549 (lung cancer).
Keywords: β2-aminoacidates; Casiopeínas®; copper; cytotoxic activity β2-aminoacidates; Casiopeínas®; copper; cytotoxic activity

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MDPI and ACS Style

Chavelas-Hernández, L.; Hernández-Vázquez, L.G.; Valdez-Camacho, J.R.; Espinoza-Guillén, A.; Tavira-Montalvan, C.A.; Meneses-Acosta, A.; Juaristi, E.; Ruiz-Azuara, L.; Escalante, J. Synthesis of (1,10-Phenanthroline-k2N,N′)(β2-Methyl- and β2-PhenylAlaninate-k2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines. Molecules 2025, 30, 634. https://doi.org/10.3390/molecules30030634

AMA Style

Chavelas-Hernández L, Hernández-Vázquez LG, Valdez-Camacho JR, Espinoza-Guillén A, Tavira-Montalvan CA, Meneses-Acosta A, Juaristi E, Ruiz-Azuara L, Escalante J. Synthesis of (1,10-Phenanthroline-k2N,N′)(β2-Methyl- and β2-PhenylAlaninate-k2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines. Molecules. 2025; 30(3):634. https://doi.org/10.3390/molecules30030634

Chicago/Turabian Style

Chavelas-Hernández, Leticia, Luis G. Hernández-Vázquez, Jonathan R. Valdez-Camacho, Adrián Espinoza-Guillén, Carlos A. Tavira-Montalvan, Angélica Meneses-Acosta, Eusebio Juaristi, Lena Ruiz-Azuara, and Jaime Escalante. 2025. "Synthesis of (1,10-Phenanthroline-k2N,N′)(β2-Methyl- and β2-PhenylAlaninate-k2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines" Molecules 30, no. 3: 634. https://doi.org/10.3390/molecules30030634

APA Style

Chavelas-Hernández, L., Hernández-Vázquez, L. G., Valdez-Camacho, J. R., Espinoza-Guillén, A., Tavira-Montalvan, C. A., Meneses-Acosta, A., Juaristi, E., Ruiz-Azuara, L., & Escalante, J. (2025). Synthesis of (1,10-Phenanthroline-k2N,N′)(β2-Methyl- and β2-PhenylAlaninate-k2N,O)Copper(II) Nitrate Complexes and Their Antiproliferative Activity on MCF-7 and A549 Cancer Cell Lines. Molecules, 30(3), 634. https://doi.org/10.3390/molecules30030634

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