Herpes simplex virus infection is caused by Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), Simplex viruses in the order Herpesvirales of dsDNA viruses. Humans are the only natural host and reservoir for the HSV virus. HSV are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. HSV infects the human host via mucosal surfaces or damaged skin, and most primary infections are asymptomatic. HSV-1 is mainly associated with orofacial lesions, yet it is also the cause of infectious blindness and viral encephalitis in adults. HSV-2 is mainly associated with genital lesions and neonatal encephalitis.
Category
Viral infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
Predominantly sexually transmitted infections
1A94 Anogenital herpes simplex infection
H00365 Herpes simplex virus infection
Viral infections characterised by skin or mucous membrane lesions
1F00 Herpes simplex infections
H00365 Herpes simplex virus infection
Pathway-based classification of diseases [BR:br08402]
Signal transduction
nt06516 TNF signaling
H00365 Herpes simplex virus infection
nt06522 mTOR signaling
H00365 Herpes simplex virus infection
Cellular process
nt06524 Apoptosis
H00365 Herpes simplex virus infection
Immune system
nt06513 Complement cascade
H00365 Herpes simplex virus infection
nt06517 TLR signaling
H00365 Herpes simplex virus infection
nt06521 NLR signaling
H00365 Herpes simplex virus infection
nt06519 RLR signaling
H00365 Herpes simplex virus infection
nt06520 CGAS-STING signaling
H00365 Herpes simplex virus infection
Genome-based classification of infectious diseases [BR:br08401]
Viral infections
Infections caused by dsDNA viruses
H00365 Herpes simplex virus infection
Infectious diseases by law in Japan [br08406.html]
H00365
