| Entry |
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| Name |
Dexamethasone acefurate (USAN/INN) |
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| Formula |
C29H33FO8
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| Exact mass |
528.2159
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| Mol weight |
528.56
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D02591 Dexamethasone acefurate (USAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D02591 Dexamethasone acefurate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D02591 Dexamethasone acefurate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D02591 Dexamethasone acefurate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D02591 Dexamethasone acefurate (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02591
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 38
1 C2x C 18.2728 -16.5491
2 C5x C 18.2728 -17.9064
3 C2x C 19.4482 -18.5850
4 C2y C 20.6236 -17.9064
5 C1z C 20.6236 -16.5491
6 C2x C 19.4482 -15.8705
7 C1x C 21.7991 -18.5850
8 C1x C 22.9744 -17.9064
9 C1y C 22.9744 -16.5491
10 C1z C 21.7991 -15.8705
11 C1y C 24.1499 -15.8705
12 C1z C 24.1499 -14.5132
13 C1x C 22.9744 -13.8346
14 C1y C 21.7991 -14.5132
15 C1x C 26.5007 -15.8705
16 C1y C 26.5007 -14.5132
17 C1z C 25.3253 -13.8346
18 C1a C 20.6236 -15.1918
19 O1a O 20.6256 -13.8358
20 C1a C 24.1499 -13.1560
21 C1a C 27.6636 -13.8417
22 C5a C 25.3253 -12.1381
23 X F 21.7991 -17.2277
24 O7a O 27.0607 -12.7365
25 O5x O 17.0975 -18.5850
26 O5a O 26.5047 -11.4572
27 C1b C 24.1538 -11.4617
28 O7a O 22.9968 -12.1299
29 C7a C 28.4607 -12.7365
30 O6a O 29.1691 -13.9642
31 C8y C 29.1663 -11.5142
32 C8x C 30.5663 -11.5142
33 C8x C 30.9989 -10.1827
34 C8x C 29.8663 -9.3598
35 O2x O 28.7337 -10.1827
36 C7a C 21.8011 -11.4393
37 C1a C 20.5786 -12.1452
38 O6a O 21.8019 -10.0104
BOND 42
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 5 18 1 #Up
22 14 19 1 #Up
23 12 20 1 #Up
24 16 21 1 #Down
25 17 22 1 #Up
26 10 23 1 #Down
27 17 24 1 #Down
28 2 25 2
29 22 26 2
30 22 27 1
31 27 28 1
32 24 29 1
33 29 30 2
34 29 31 1
35 31 32 2
36 32 33 1
37 33 34 2
38 34 35 1
39 31 35 1
40 28 36 1
41 36 37 1
42 36 38 2
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