Inflammatory mechanisms in obesity
MF Gregor, GS Hotamisligil - Annual review of immunology, 2011 - annualreviews.org
The modern rise in obesity and its strong association with insulin resistance and type 2
diabetes have elicited interest in the underlying mechanisms of these pathologies. The
discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a
research field that examines the inflammatory mechanisms in obesity. Here, we summarize
the unique features of this metabolic inflammatory state, termed metaflammation and defined
as low-grade, chronic inflammation orchestrated by metabolic cells in response to excess …
diabetes have elicited interest in the underlying mechanisms of these pathologies. The
discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a
research field that examines the inflammatory mechanisms in obesity. Here, we summarize
the unique features of this metabolic inflammatory state, termed metaflammation and defined
as low-grade, chronic inflammation orchestrated by metabolic cells in response to excess …