Dr. Sam and many Middletoners take up running to train for an upcoming race. A mysterious woman catches Derek's interest but Brandon is suspicious; a mysterious man follows her around.
Against her best judgment, Cassie agrees to pose as Ryan's girlfriend to make his ex jealous, but this confuses the good doctor and Cassie herself when she and Ryan kiss.
Cousin Abigail Pershing returns to wreak havoc in Middleton as she sets her sights on Dr. Sam who is dating Stephanie. Ryan wants to date his best friend, Cassie.
Sam, Nick, Abigail, Grace and Cassie all deal with their control issues. Abigail explains to Cassie how she has been helping everyone since her return to Middleton.
Sam's Ex-wife turns up to use Nick to get to Sam. She conspires to get Nick to Hong Kong behind Sam's back, causing mayhem and destruction of feelings. Cassie struggles with the after events of Bryan being in the hospital and her daughter Grace continues to be manipulated by Abigail.
