Wife, mother, and psychic Allison DuBois (Arquette) can communicate with the dead and is convinced she can use her gift to help solve crimes. She's put to the test when she gets a call from the Texas Rangers.
Allison is partnered with Detective Lee Scanlon on a case involving the strange murders of newlywed couples. Joe tries to plan a surprise party for Allison.
Allison's dream couldn't be more confusing, mimicking the story line of "Little Red Riding Hood": a snarling wolf chases her through a Phoenix airport where she has no choice but to jump from a jetway.
When visiting another psychic, Allison is told that there is a dark cloud over her marriage and this has a snowball effect on Alison both at work and at and home.
Allison believes a supposed Good Samaritan raped and murdered a red-haired college student. Meanwhile, Allison may be pregnant and Ariel may be a math genius.
Allison knows there's more than mere suicide to the story of a girl who jumps off a cliff. Meanwhile, she predicts her husband's co-worker will have a fatal heart attack.
Allison's half-brother Michael returns from duty in Afghanistan with the nickname Lucky. He's deeply troubled, and Allison recognises his binge-drinking as an attempt to mask his 'gift' - Allison insists he be honest with himself.
Nightmares of a cruel ogre haunt Ariel. While Joe is worried about these dreams, Allison believes that Ariel can help a kidnapped girl by decoding her dreams.
Allison's recurring dream of two young boys who are racing a train leads her to Professor Leonard Cardwell whose area of expertise is communication with the afterlife.
Allison is sick. The medicine she takes makes her have strange dreams - stranger than usual dreams. She dreams she is involved in a very old TV show called I Married A Mind Reader. She's not sure the real life murderer is the right person.
Allison has a dream about a pilot who saves a plane from crashing. Later she finds out that the pilot is suspected of a murder and she gets confused about what her dream means with regard to the murder.
Things go from bad to worse when Allison's mother-in-law comes to visit. A once-closed case is re-opened to try to find out if the convicted person is actually innocent.
Allison encounters a psychopathic doctor who raped and murdered numerous teenage girls years ago. After learning that an evil soul has been possessing people, she sets forth to stop it before a new victim is found.
After seeing Capt. Kenneth Push in a vision at a murder scene, Allison calls upon his assistance to find a serial killer. However, the only way Capt. Push can help is by literally putting his life on the line.