A brief establishing shot of Baker Street, with a street-cleaning cart passing by, is actually a piece of footage from The Private Life of Sherlock Holmes (1970).
Thorley Walters, who had played Dr. Watson in several different projects, replaced Trevor Howard as Major John Sholto, marking the final time Walters would play a character in the Sherlock Holmes canon on screen.
Ian Richardson later appeared in Murder Rooms: Mysteries of the Real Sherlock Holmes (2000) as Dr. Joseph Bell, the real-life inspiration for Holmes.
Early in the movie, Holmes makes some inferences regarding Watson's brother. In the original stories--specifically "A Study in Scarlet"-Watson says, "Having neither kith nor kin . . . ". In other words, Dr. Watson has no brother. Furthermore, about halfway through the movie, Holmes utters the famous line, "Elementary, my dear Watson." This sentence never appears in any of the original stories by Arthur Conan Doyle].
In the novel on which the movie is based, Holmes is indulging in his cocaine habit when Watson shows him the pocket watch. Here, he is conducting an experiment on tobacco smoke.
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