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Multiple teams race around the globe for $1,000,000 to 'amazing' locations.

Fu Manchu seizes a Turkish castle for its stockpile of opium, as he needs the drug as part of his plot to freeze the Earth's oceans.

Since Yumurcak lives in a world of fantasy, nobody believes what he says. When one day their neighbor Kenan and wife murder someone, the same thing happens. He talks about the murder but no one believes him. Kenan is aware of Yumurcak and wants to get rid of the little witness.

Two teams explore flight options and successfully risk an earlier flight, while two others choose to play it safe with a flight that ends up coming in later. In England, the teams ride a Ferris wheel called the London Eye and then participate in a Detour that requires them to make a classic choice --- Brains or Brawn. Uchenna and Joyce and Meredith and Gretchen both opt for Brawn, which requires them to stack boats, while the other two teams go for Brains and solve a series of clues leading them to the home of the legendary Sherlock Holmes. Seeing Meredith and Gretchen struggle, Uchenna attempts to help out before realizing that he's not allowed. Later, the teams do a Roadblock at the Millennium Dome in which they must drive a double-decker bus through a marked obstacle course. One team surges ahead, while a Yield puts the remaining three teams in a close competition to avoid elimination.

Once in Turkey, the teams participate in a sponsorship-placed gnome-finding task and then encounter a Detour which requires them to choose between Columns or Kilos. Most teams opt for Kilos, which requires them to weight people on a scale, but Ron and Kelly choose Columns, in which they have to use a coordinate grid to find columns with numbers and then use them as a combination for a lock. Later, a Roadblock requires one member of each team to rappel up a tall fortress and locate a key. The teams jockey for position heading for the Pit Stop, all while wondering about the significance of the gnome picked up earlier in the leg.

The eight teams stay in Istanbul, Turkey, where among the challenges they face are soapy baths, oil wrestling and shoe shining. Will some teams be pushed to breaking point by the pressure as the competition heats up?