Jon Cryer and Brian Patrick Wade in Two and a Half Men (2003)

Johnny Galecki and Brian Patrick Wade in The Big Bang Theory (2007)

Johnny Galecki, Brian Patrick Wade, and Jim Parsons in Pilot (2007)

Johnny Galecki, Simon Helberg, Brian Patrick Wade, Jim Parsons, and Kunal Nayyar in The Big Bang Theory (2007)

Kaley Cuoco, Johnny Galecki, Brian Patrick Wade, and Jim Parsons in The Big Bang Theory (2007)

LL Cool J and Brian Patrick Wade in NCIS: Los Angeles (2009)

Brian Wade at HBO's "Generation Kill" premier

Kaley Cuoco, Johnny Galecki, and Brian Patrick Wade in The Big Bang Theory (2007)