- Has never married and has no children. Interviewed in 2016, she said, "I've never wanted to marry, I've never wanted children - I was born without that gene.".
- Credits Ingrid Bergman as one of her favorite actresses, and the reason she became one.
- Some of her favorite movies are: Desk Set (1957), Driving Miss Daisy (1989), Gaslight (1944), Gosford Park (2001), Sexy Beast (2000), and Y tu mamá también (2001).
- The youngest of five girls.
- Went to ivy-league Yale college to study dramatic arts.
- After working with director Will Gluck she vowed to star in every movie he would make from then on and subsequently starred in his films Friends with Benefits (2011) and Annie (2014).
- For a few years after Roger Dodger (2002) premiered at the 2002 Tribeca Film Festival, she was the girlfriend of Campbell Scott.
- Graduated Fordham University's College at Lincoln Center, 1982.
- Won the 2019 Golden Globe Award in the Best Performance by an Actress in a Supporting Role in a Series, Limited Series or Motion Picture Made for Television category for her role as Adora Crellin in Sharp Objects (2018).
- Nominated in the Outstanding Actress in Made for Television Movie FIVE, at The Women's Image Network (WIN) Awards 2012.
- Daughter of New Orleans, LA councilwoman Jackie Clarkson.
- Close friend of Amy Ryan.
- Was member of the dramatic jury at the Sundance Film Festival in 2000.
- Her most memorable screen kiss was with British actor Darwin Shaw in season 6 of the series House of Cards (2013). Least memorable kiss was with Robert Downey Jr. in Good Night, and Good Luck. (2005).
- Her maternal grandmother was the daughter of a Basque Spanish father and a Lithuanian Jewish mother. Patricia's other ancestry includes French/Cajun, German, English, Irish, Scottish, Scots-Irish/Northern Irish, and remote Dutch.
- In 2003 she was in two different independent films with prominent cast members from Dawson's Creek (1998). In The Station Agent (2003) Michelle Williams played an acquaintance from the same small town as Patricia's character and in Pieces of April (2003) Patricia played the mother of the title character portrayed by Katie Holmes.
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