- When Patricia Arquette first met Nicolas Cage, she felt he was coming on too strong and tried to discourage him. She gave him an impossible list of accomplishments that he would have to meet before he she would go out with him. Over the next couple months she was shocked to find out that he had been working his way through the list.
- Is the first member of the Arquette family to receive an Oscar nomination, and also the first to win the prize.
- Attended Mid-City Alternative school on the corner of Adams Blvd. and Arlington Avenue in the mid 1970s. Her two brothers, David Arquette and Richmond Arquette, also attended this school.
- Is one of two actresses who have won both the Best Supporting Actress Oscar (hers being for Boyhood (2014)) and the Outstanding Lead Actress in a Drama Series Emmy (hers being for Medium (2005)). The other actress is Viola Davis.
- If her acting career didn't work out, her other career desire was to go to college and become a midwife.
- Co-founder of "GiveLove," an organization dedicated to community-led sanitation projects in Haiti since the devastating earthquake of 2010.
- Is one of 13 actresses to have won the Academy Award, BAFTA Award, Critics' Choice Award, Golden Globe Award and SAG Award for the same performance. The others in chronological order are Julia Roberts for Erin Brockovich (2000), Renée Zellweger for Cold Mountain (2003), Reese Witherspoon for Walk the Line (2005), Helen Mirren for The Queen (2006), Jennifer Hudson for Dreamgirls (2006), Kate Winslet for The Reader (2008), Mo'Nique for Precious (2009), Natalie Portman for Black Swan (2010), Octavia Spencer for The Help (2011), Anne Hathaway for Les Misérables (2012), Cate Blanchett for Blue Jasmine (2013) and Julianne Moore for Still Alice (2014).
- In her Oscar acceptance speech for Boyhood (2014) she made remarks about gender inequality, which instantly went viral as the millions of people watching the telecast at home weighed in. Women's groups say that the only times they have seen more buzz around the topic of income disparity was when Lilly Ledbetter, the activist who sued Goodyear for paying her less than male counterparts, addressed the Democratic National Convention in 2008 and 2012, and when Barack Obama took up the mantle of equal pay in State of the Union address in 2015.
- The family surname was spelled "Arcouet" many generations back. Her father had French-Canadian, English, Swiss-German, German, Scottish, Irish, and Welsh ancestry. Patricia's maternal grandfather, Yusseff "Joseph" Nowack, was a Jewish emigrant from Bila Zerkwa, Kiev, then in the Russian Empire, while Patricia's maternal grandmother, Claire Hibel, was born in New York, to Russian Jewish parents.
- Is the only actress from the "A Nightmare on Elm Street" franchise to win an Academy Award.
- Was originally cast in the Jennifer Jason Leigh role opposite her brother, Alexis Arquette, in Last Exit to Brooklyn (1989) but had to drop out because of her pregnancy.
- In an interview with Magnet (June-July 1999), Tom Waits admitted that a line in "Black Market Baby" was inspired by Arquette. His wife observed of Arquette, "She's a bonsai Aphrodite". The track is found on the "Mule Variations".
- Her NBC-TV show Medium (2005) briefly aired in the same time slot as her sister, Rosanna Arquette's ABC-TV show What About Brian (2006).
- Was set to reprise her role of Kristen Parker in A Nightmare on Elm Street 4: The Dream Master (1988) but was forced to decline because she became pregnant of her son Enzo Rossi.
- Filed for divorced from Thomas Jane in January 2009, citing "irreconcilable differences", but they reunited just weeks later. They split for good in August 2010.
- Former stepmother of Nicolas Cage's son, Weston Cage.
- Daughter of Lewis Arquette and Brenda Denaut. Sister of Richmond Arquette, Alexis Arquette, David Arquette and Rosanna Arquette. Granddaughter of the late Cliff Arquette, TV character "Charley Weaver" and Julie Harrison. Aunt of Zoë Bleu Sidel (Rosanna's daughter), Coco Arquette, Charlie West & Augustus Alexis Arquette (David's children).
- Gave birth to her first child at age 20, a son Enzo Luciano Rossi (aka Enzo Rossi) on January 3, 1989. Child's father is her ex-boyfriend Paul Rossi. Gave birth to her second child at age 34, a daughter Harlow Olivia Calliope Jane (Elliott) aka Harlow Jane on February 23, 2003. Child's father is her boyfriend [now ex-second husband], Thomas Jane.
- Former sister-in-law of Tony Greco, James Newton Howard and John Sidel. They were each married to her sister, Rosanna Arquette. Former sister-in-law of Courteney Cox.
- Actress Valeria Golino was her witness at her marriage to Thomas Jane.
- Married Thomas Jane at the Palazzo Contarini in Venice
- August 2002: Became engaged to actor Thomas Jane.
- Was the 143rd actress to receive an Academy Award; she won the Best Supporting Actress Oscar for Boyhood (2014) at The 87th Annual Academy Awards on February 22, 2015.
- Considered for the role of Honey Bunny in Pulp Fiction. The role eventually went to Amanda Plummer.
- Considered for the role of Dorothy Boyd in Jerry Maguire (1996).
- Attended Los Angeles Center for Enriched Studies in Los Angeles, California.
- Was member of the dramatic jury at the Sundance Film Festival in 2002.
- Honored with Variety's Creative Impact in Cinema Award for her supporting actress role in the film Boyhood at the Texas Film Awards ceremony held on March 12, 2015 in Austin, Texas.
- Sister-in-law of Todd Morgan, Rosanna's 4th husband. Sister-in-law of Christina McLarty Arquette, David's second wife.
- Had a mole on the left side of her neck that was removed in 1998.
- She was born at 11:55 a.m. (EST).
- Thus far, she is only Oscar winner to appear in the Nightmare On Elm Street franchise.
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