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Volume 21 (3); 2025

Editorial

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Cancer can be a purely epigenetic disorder
Ya Meng, Heng Sun, Chu-Xia Deng
Int. J. Biol. Sci. 2025; 21(3): 955-957. doi:10.7150/ijbs.109274
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Research Papers

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USP5 Binds and Stabilizes EphA2 to Increase Nasopharyngeal Carcinoma Radioresistance
Jie-Yu Tang, Yun-Xi Peng, Wei Zhu, Jie-Ya Qiu, Wei Huang, Hong Yi, Shan-Shan Lu, Juan Feng, Zheng-Zheng Yu, Di Wu, Qi Wen, Li Yuan, Jinwu Peng, Zhi-Qiang Xiao
Int. J. Biol. Sci. 2025; 21(3): 893-909. doi:10.7150/ijbs.102461
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Senescent renal tubular cells derived extracellular vesicles transported miR-20a and miR-21 induced macrophage-to-myofibroblast transition in renal fibrosis after ischemia reperfusion injury
Qiang Zhong, Jun Zeng, Yue Li, Haohan Zhang, Tao Lin, Turun Song
Int. J. Biol. Sci. 2025; 21(3): 940-954. doi:10.7150/ijbs.97579
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Intratumoral Stenotrophomonas Maltophilia in Breast Cancer: Unraveling the Interplay with Hormone Receptors and Impact on Tumor Immunity
Qian Zhang, Dujuan Wang, Guangzheng Zhuo, Shilin Wang, Yufen Yuan, Liping Wang, Lili Ji, Yuhang Wan, Guohong Liu, Yunbao Pan
Int. J. Biol. Sci. 2025; 21(3): 974-988. doi:10.7150/ijbs.98260
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Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling
Haina Zhang, Wenqian Zhou, Xiang Wang, Hongbo Men, Jiqun Wang, Jianxiang Xu, Shanshan Zhou, Quan Liu, Lu Cai
Int. J. Biol. Sci. 2025; 21(3): 1032-1046. doi:10.7150/ijbs.105513
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FOXM1-Driven CKS1B Upregulation Promotes Pancreatic Cancer Progression and Therapeutic Resistance
Liuxi Zhang, Fang Wei, Qihui Sun, Xinyan Huang, Qi Zou, Mengmeng Jiang, Yuling Su, Shu Li, Xiaojia Li, Keping Xie, Jie He
Int. J. Biol. Sci. 2025; 21(3): 1047-1064. doi:10.7150/ijbs.105289
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Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development
Tianzi Wei, Risheng Lin, Yi Lu, Dong-Yan Jin, Jian Zhang, Mai Har Sham
Int. J. Biol. Sci. 2025; 21(3): 1081-1096. doi:10.7150/ijbs.99619
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Tumor-associated macrophages drive heterogenetic CD10High cancer stem cells to implement tumor-associated neutrophils reprogramming in oral squamous cell carcinoma
Yuanhe You, Zhong Du, Zhuowei Tian, Shunshun Li, Fan Yu, Meng Xiao, Yue He, Yanan Wang
Int. J. Biol. Sci. 2025; 21(3): 1110-1126. doi:10.7150/ijbs.100611
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TTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation
Qianwen Ren, Meiyi Xiang, Juanli Qiao, Zhaojun Liu, Ge Zhang, Liankun Gu, Jing Zhou, Wei Tian, Dajun Deng
Int. J. Biol. Sci. 2025; 21(3): 1127-1143. doi:10.7150/ijbs.102431
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Ugonin inhibits chondrosarcoma metastasis through suppressing cathepsin V via promoting miR-4799-5p expression
Nguyen Bao Tran, Ting-Kuo Chang, Nguyen Duong Phuong Chi, Kuan-Ying Lai, Hsien-Te Chen, Yi-Chin Fong, Chih-Chuang Liaw, Chih-Hsin Tang
Int. J. Biol. Sci. 2025; 21(3): 1144-1157. doi:10.7150/ijbs.106827
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Tetramethylpyrazine attenuates sodium arsenite-induced acute kidney injury by improving the autophagic flux blockade via a YAP1-Nrf2-p62-dependent mechanism
Zhiyong Song, Tom K. Hei, Xuezhong Gong
Int. J. Biol. Sci. 2025; 21(3): 1158-1173. doi:10.7150/ijbs.104107
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GATA6 Facilitates Progression of Intervertebral Disc Degeneration by Regulating Ferroptosis via Targeting TLR2/AKR1C3
Xiaobo Wang, Bingyu Wang, Jiawei Shi, Zefu Chen, Yongpei Wu, Jingmin Liu, Zhongmin Zhang, Yang Wang, Jia Dan, Xin Zheng
Int. J. Biol. Sci. 2025; 21(3): 1174-1186. doi:10.7150/ijbs.102776
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TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4
Xin Zhou, Yuqing Zhao, Shixue Huang, Haoming Shu, Yinuo Zhang, Haiyuan Yang, Yilong Ren, Xuhui Zhou, Wei Liu, Tengfei Song, Jianquan Zhao, Jun Ma
Int. J. Biol. Sci. 2025; 21(3): 1259-1274. doi:10.7150/ijbs.106690
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Exosomal miR-375-3p mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN
Chen Zhang, Pei Qiao, ChunYing Xiao, ZiPeng Cao, JiaoLing Chen, Hui Fang, JianKang Yang, ZeHua Kang, ErLe Dang, Shuai Shao, BingYu Pang, QingYang Li, ZhenLai Zhu, ShengXian Shen, Akito Hasegawa, Riichiro Abe, HongJiang Qiao, Gang Wang, Meng Fu
Int. J. Biol. Sci. 2025; 21(3): 1275-1293. doi:10.7150/ijbs.98592
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Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis
Qi Fang, Qi Yan, Xingyun Liu, Xiaolu Zhang, Lixia Zha, Ruixin Zhang, Zhixin Gao, Jian Du, Lijian Chen
Int. J. Biol. Sci. 2025; 21(3): 1294-1307. doi:10.7150/ijbs.103789
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Downregulation of PGAM2 alleviates angiotensin II-induced cardiac hypertrophy by destabilizing HSP90 and inactivating the mTOR/IKKα signaling pathway
Ying Li, Wen-jing Li, Jia-min Du, Hui-hui Wu, Si-yuan Zhou, Min Li, Yue-yan Li, Shu-ya Wang, Hui-yun Wang, Yan Zheng, Qun-ye Zhang, Li-ming Li, Fan-liang Meng, Guo-hai Su
Int. J. Biol. Sci. 2025; 21(3): 1308-1321. doi:10.7150/ijbs.102251
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Reviews

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Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy
Xin Yu, Wei Pei, Bei Li, Shengrong Sun, Wenge Li, Qi Wu
Int. J. Biol. Sci. 2025; 21(3): 910-939. doi:10.7150/ijbs.100948
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Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy
Ruirui Wang, Xin Dong, Xiongjian Zhang, Jinzhuang Liao, Wei Cui, Wei Li
Int. J. Biol. Sci. 2025; 21(3): 958-973. doi:10.7150/ijbs.103877
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Traditional Chinese Medicine for Viral Pneumonia Therapy: Pharmacological Basis and Mechanistic Insights
Yinglu Bai, Tengwen Liu, Shuwen Zhang, Yifan Shi, Yumei Yang, Maoyu Ding, Xiaowei Yang, Shanshan Guo, Xiaolong Xu, Qingquan Liu
Int. J. Biol. Sci. 2025; 21(3): 989-1013. doi:10.7150/ijbs.105086
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Regulatory Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer's Disease
Yeji Kim, Tae-Young Ha, Myung-Shik Lee, Keun-A Chang
Int. J. Biol. Sci. 2025; 21(3): 1014-1031. doi:10.7150/ijbs.103028
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The Role of mRNA Modifications in Bone Diseases
Zehui Li, Keyu Meng, Shanwei Lan, Zhengda Ren, Zhongming Lai, Xiang Ao, Zhongyuan Liu, Jiajia Xu, Xiaoyi Mo, Zhongmin Zhang
Int. J. Biol. Sci. 2025; 21(3): 1065-1080. doi:10.7150/ijbs.104460
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Regulation of nitric oxide generation and consumption
Husam M Abu-Soud, Olivia G Camp, Jayanth Ramadoss, Charalampos Chatzicharalampous, George Kofinas, Jason D Kofinas
Int. J. Biol. Sci. 2025; 21(3): 1097-1109. doi:10.7150/ijbs.105016
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The Mechanism and Latest Progress of m6A Methylation in the Progression of Pancreatic Cancer
Ze-Hao Liu, Peng Ma, Ying He, Yue-Feng Zhang, Zuo Mou, Ting Fang, Wei Wang, Kai-Huan Yu
Int. J. Biol. Sci. 2025; 21(3): 1187-1201. doi:10.7150/ijbs.104407
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Revisiting of Cancer Immunotherapy: Insight from the Dialogue between Glycolysis and PD-1/PD-L1 Axis in the Tumor Microenvironment
Qiong Liu, Zihan Liu, Xi Zhang, Anqi Zeng, Linjiang Song
Int. J. Biol. Sci. 2025; 21(3): 1202-1221. doi:10.7150/ijbs.104079
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Targeting ferroptosis to enhance the efficacy of mesenchymal stem cell-based treatments for intervertebral disc degeneration
Yuzhu Xu, Xuanfei Xu, Renjie Chai, Xiaotao Wu
Int. J. Biol. Sci. 2025; 21(3): 1222-1241. doi:10.7150/ijbs.107021
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Updated review of research on the role of the gut microbiota and microbiota-derived metabolites in acute pancreatitis progression and inflammation-targeted therapy
Qiang Liu, Kaiyi Ruan, Zihui An, Lingyun Li, Cong Ding, Dongchao Xu, Jianfeng Yang, Xiaofeng Zhang
Int. J. Biol. Sci. 2025; 21(3): 1242-1258. doi:10.7150/ijbs.108858
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