KEGG   NETWORK: N01765
Entry
N01765                      Network                                
Name
CXCR4-GNAQ-PLCB/G signaling pathway
Definition
CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG)
  Expanded
6387 -> 7852 -> 2776 -> (23236,5330,5331,5332,5335,5336)
Class
nt06533 Chemokine signaling
Type
Reference
Pathway
hsa04062  Chemokine signaling pathway
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:28231592
  Authors
Knopf A, Fritsche MK, Li Y
  Title
CXCR4: A New Player in an Old Scene?
  Journal
ORL J Otorhinolaryngol Relat Spec 79:34-42 (2017)
DOI:10.1159/000455706
Reference
PMID:26199389
  Authors
Scala S
  Title
Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment.
  Journal
Clin Cancer Res 21:4278-85 (2015)
DOI:10.1158/1078-0432.CCR-14-0914
Reference
PMID:20049170
  Authors
Barbieri F, Bajetto A, Florio T
  Title
Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target.
  Journal
J Oncol 2010:426956 (2010)
DOI:10.1155/2010/426956

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Gene (9)   
   KEGG GENES (9)   
Literature (4)   
   PubMed (4)   
All databases (14)   

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