FZD7
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| Uvojiti receptor 7 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | FZD7; FzE3 | ||||||||||
| Vanjski ID | OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8324 | 14369 | |||||||||
| Ensembl | ENSG00000155760 | ENSMUSG00000041075 | |||||||||
| UniProt | O75084 | Q810L8 | |||||||||
| RefSeq (mRNA) | NM_003507.1 | NM_008057.3 | |||||||||
| RefSeq (protein) | NP_003498.1 | NP_032083.3 | |||||||||
| Lokacija (UCSC) | Chr 2: 202.9 - 202.9 Mb | Chr 1: 59.54 - 59.54 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Uvojiti-7 je protein koji je kod ljudi kodiran FZD7 genom.[1][2][3]
Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskim karcinomima jednjaka.[3]
FZD7 formira interakcije sa DLG4.[4]
- ↑ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun 252 (1): 117–22. DOI:10.1006/bbrc.1998.9607. PMID 9813155.
- ↑ 3,0 3,1 „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.
- ↑ Hering, Heike; Sheng Morgan (June 2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. (Netherlands) 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.
- Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. PMID 12067714.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”. Oncogene 23 (36): 6023–30. DOI:10.1038/sj.onc.1207817. PMID 15195140.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vincan E, Darcy PK, Smyth MJ, et al. (2005). „Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth”. Differentiation 73 (4): 142–53. DOI:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
- Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). „A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell 125 (4): 801–14. DOI:10.1016/j.cell.2006.03.032. PMID 16713569.
- Vincan E, Darcy PK, Farrelly CA, et al. (2007). „Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids”. Oncogene 26 (16): 2340–52. DOI:10.1038/sj.onc.1210026. PMID 17016432.
- Struewing IT, Barnett CD, Zhang W, et al. (2007). „Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1”. Exp. Cell Res. 313 (16): 3526–41. DOI:10.1016/j.yexcr.2007.07.012. PMID 17716656.
- „Frizzled Receptors: FZD7”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.