Izvorni kod stranice LPAR1

{{PBB|geneid=1902}}
'''Receptor lizofosfatidne kiseline 1''' (''LPA<sub>1</sub>'') je [[protein]] koji je kod ljudi kodiran ''LPAR1'' [[gen]]om.<ref name="entrez">{{cite web | title = Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1902| accessdate = }}</ref><ref name="pmid8922387">{{cite journal | author = Hecht JH, Weiner JA, Post SR, Chun J | title = Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex | journal = J. Cell Biol. | volume = 135 | issue = 4 | pages = 1071–83 | year = 1996 | month = November | pmid = 8922387 | pmc = 2133395 | doi = 10.1083/jcb.135.4.1071| url =https://archive.org/details/sim_journal-of-cell-biology_1996-11_135_4/page/1071| issn = }}</ref><ref name="pmid9070858">{{cite journal | author = An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ | title = Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid | journal = Biochem. Biophys. Res. Commun. | volume = 231 | issue = 3 | pages = 619–22 | year = 1997 | month = February | pmid = 9070858 | doi = 10.1006/bbrc.1997.6150 | url = | issn = }}</ref> LPA<sub>1</sub> je [[G protein spregnuti receptor]] za koji se vezuje lipidni signalni molekul [[lizofosfatidna kiselina]] (LPA).<ref name = "Choi_2010">{{cite journal | author = Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J | year = 2010 | month = January | title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume = 50 | issue = 1 | pages = 157–186 | doi = 10.1146/annurev.pharmtox.010909.105753 | url = http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.010909.105753 | pmid = 20055701 }}{{Dead link|date=October 2022 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>

== Funkcija ==
Integralni membranski protein kodiran ovim genom pripada grupi [[Gen endotelne diferencijacije|EDG]] receptora. Ti receptori su članovi familije G protein spregnutih receptora. EDG receptori posreduju različite bioločkie funkcije, uključujući proliferaciju, agregaciju trombocita, kontrakcije glatkih mišića, inhibiciju diferencijaciju neuroblastomnih ćelija, [[hemotaksa|hemotaksu]], i invaziju tumornih ćelija. [[Alternativno splajsovanje]] ovog gena je uočeno i dve transkriptne varijante su opisane. One kodiraju identične proteine.<ref name="entrez"/>

== Reference ==
{{reflist|2}}

== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=An S, Goetzl EJ, Lee H |title=Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. |journal=J. Cell. Biochem. Suppl. |volume=30-31 |issue=  |pages= 147–57 |year= 1999 |pmid= 9893266 |doi=  }}
*{{cite journal  | author=Contos JJ, Ishii I, Chun J |title=Lysophosphatidic acid receptors. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1188–96 |year= 2001 |pmid= 11093753 |doi=  }}
*{{cite journal  | author=Moolenaar WH, Kranenburg O, Postma FR, Zondag GC |title=Lysophosphatidic acid: G-protein signalling and cellular responses. |journal=Curr. Opin. Cell Biol. |volume=9 |issue= 2 |pages= 168–73 |year= 1997 |pmid= 9069262 |doi=10.1016/S0955-0674(97)80059-2  }}
*{{cite journal  | author=Fukushima N, Kimura Y, Chun J |title=A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 11 |pages= 6151–6 |year= 1998 |pmid= 9600933  | pmc=27607 |doi=10.1073/pnas.95.11.6151  }}
*{{cite journal  | author=An S, Bleu T, Zheng Y, Goetzl EJ |title=Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. |journal=Mol. Pharmacol. |volume=54 |issue= 5 |pages= 881–8 |year= 1998 |pmid= 9804623 |doi=  }}
*{{cite journal  | author=Cervera P, Tirard M, Barron S, ''et al.'' |title=Immunohistological localization of the myelinating cell-specific receptor LP(A1). |journal=Glia |volume=38 |issue= 2 |pages= 126–36 |year= 2002 |pmid= 11948806 |doi=10.1002/glia.10054  }}
*{{cite journal  | author=Hama K, Bandoh K, Kakehi Y, ''et al.'' |title=Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. |journal=FEBS Lett. |volume=523 |issue= 1-3 |pages= 187–92 |year= 2002 |pmid= 12123830 |doi=10.1016/S0014-5793(02)02976-9  }}
*{{cite journal  | author=Van Leeuwen FN, Olivo C, Grivell S, ''et al.'' |title=Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 400–6 |year= 2003 |pmid= 12393875 |doi= 10.1074/jbc.M210151200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932  | pmc=139241 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H |title=Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 1969–80 |year= 2004 |pmid= 12668728 |doi= 10.1242/jcs.00397 }}
*{{cite journal  | author=Shida D, Kitayama J, Yamaguchi H, ''et al.'' |title=Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. |journal=Cancer Res. |volume=63 |issue= 7 |pages= 1706–11 |year= 2003 |pmid= 12670925 |doi=  }}
*{{cite journal  | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
*{{cite journal  | author=Xu J, Lai YJ, Lin WC, Lin FT |title=TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10459–68 |year= 2004 |pmid= 14688263 |doi= 10.1074/jbc.M311891200 }}
*{{cite journal  | author=Komuro Y, Watanabe T, Kitayama J, ''et al.'' |title=The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas. |journal=Hepatogastroenterology |volume=50 |issue= 54 |pages= 1770–3 |year= 2004 |pmid= 14696401 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Kaneider NC, Lindner J, Feistritzer C, ''et al.'' |title=The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. |journal=FASEB J. |volume=18 |issue= 11 |pages= 1309–11 |year= 2005 |pmid= 15208267 |doi= 10.1096/fj.03-1050fje }}
}}
{{refend}}

== Povezano ==
* [[Lizofosfolipidni receptor]]

== Spoljašnje veze ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2990 | title = Lysophospholipid Receptors: LPA<sub>1</sub> | accessdate =  | author =  | authorlink =  | coauthors =  | date =  | format =  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages =  | language =  | archiveurl = https://web.archive.org/web/20160303214806/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2990 | archivedate = 2016-03-03 | quote =  | dead-url = yes }}
* {{MeshName|Lysophospholipid+receptors}}
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{{G protein spregnuti receptori-lat}}

[[Kategorija:G protein spregnuti receptori]]