Recommendations in the FDA’s first antidepressant guidance update in over 40 years include specifics on conducting clinical trials with rapid-acting antidepressants such as ketamine. 

A placebo may be intended as a neutral placeholder, but it affects patients in quite real ways, explained experts at APA's annual meeting who have studied the role and effects of placebos.  

Though more research is necessary, researchers believe a blood test may one day be able to predict a patient’s response to antidepressants within one week. Though more research is necessary, researchers believe a blood test may one day be able to predict a patient’s response to antidepressants within one week. 

Analysis of depressed patients given either pioglitazone or placebo in addition to anti-depressants suggests that the length of these chromosomal caps correlates with how well the diabetes medication boosts antidepressant response. 

Findings suggest that people with significant childhood adversity might benefit from a combined program of naltrexone and coping/skills therapy.