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Selfish transposition model for genome rearrangements associated with RM gene complexes. Expression of an RM gene complex is disturbed. Unmethylated sites are exposed to attack by the restriction enzyme. The DNA may be further degraded in two directions from the cut ends. The host joins the broken ends. When a DNA fragment carrying the RM gene complex is properly inserted at the joint, the methylation can resume and the restriction attack will cease.
