Cells at Work! (はたらく細胞code: ja is deprecated , Hataraku Saibō) (Bahasa Melayu: Sel Bekerja!) merupakan siri manga Jepun ditulis dan diilustrasikan oleh Akane Shimizu. Ia menampilkan antropomorfisme bagi sel-sel dalam tubuh manusia, dengan dua protagonis utama iaitu sel darah merah dan neutrofil yang kerap ditemuinya. Manga ini diterbitkan secara bersiri dalam majalah manga shōnen magazine KodanshaMonthly Shōnen Sirius bermula Mach 2015. Ia dilesenkan di Amerika Utara oleh Kodansha USA. Sebuah siri anime televisyen adaptasi oleh David Production mula bersiaran pada 7 Julai 2018.[2]
Plot
Cerita bertempat dalam tubuh manusia, di mana bertrilion-trilion sel-sel antropomorfik yang melakukan kerja masing-masing bagi memastikan tubuh tersebut kekal sihat. Siri ini tertumpu kepada dua sel seumpamanya; sel darah putih baharu, AE3803, yang sering tersesat semasa melakukan penghantaran dan dan sel darah putih, U-1146, yang tidak henti-henti berlawan dengan mana-mana kuman yang cuba menakluk tubuh tersebut tanpa belas kasihan.
Senarai watak
Sel Darah Merah (AE3803) (赤血球code: ja is deprecated , Sekkekkyū)
Sel darah merah yang baru sahaja memulakan kerjanya menghantar oksigen, karbon dioksida dan pelbagai nutrien ke serata tubuh. Dia bertemu dengan Neutrofil apabila sel darah putih itu menyelamatkannya daripada serangan bakteria pneumococcus. Dia agak cemerkap dan kerap tersesat, tetapi berkeyakinan menjalankan tugas sehabis baik.
Neutrofil (好中球code: ja is deprecated , Kōchūkyū) / Sel Darah Putih (U-1146) (白血球code: ja is deprecated , Hakkekkyū)
Sejenis sel darah putih, yang kerjanya membunuh patogen yang menjangkiti tubuh. Di sebalik pekerjaannya yang kejam, dia sebenarnya seorang yang bersopan-santun dan berbudi bahasa.
Makrofaj (マクロファージcode: ja is deprecated , Makurofāji) / Monosit (単球code: ja is deprecated , Tankyū)
Sejenis sel darah putih. Dia dan sel sejenisnya ditampilkan sebagai pembantu rumah berbaju besar, bersenjatakan pelbagai senjata besar untuk membunuh pelbagai patogen penakluk, dan sering kelihatan tersenyum ceria walaupun ketika sedang berlawan. Semasa di dalam salur darah, mereka mengambil peranan sebagai monosit dan memakai sut hazmat yang meliputi baju mereka.
Sel T Pembunuh (キラーT細胞code: ja is deprecated , Kirā Tī Saibō)
Sejenis sel darah putih yang mengenal pasti dan membunuh pelbagai jirim asing dan sel-set berpenyakit. Dia kelihatan agresif, bengis dan kasar, menyembelih patogen dan sel-sel berpenyakit dengan ganas dan kejam. Dia sering memandang rendah akan sel-sel darah putih yang menjalinkan hubungan dengan sel-sel bukan darah putih, seperti persahabatan Neutrofil dengan Sel Darah Merah. Dia merupakan sarjan bagi angkatan Sel-sel T Pembunuh dan seorang guru yang kejam terhadap anak-anak muridnya, Sel-sel T Naif. Dia mempunyai hubungan yang buruk dengan Sel T Pembantu dan Sel NK, yang mana Sel T Pembantu sering tempil lebih hebat daripadanya dalam Divisyen T Pembunuh. Semasa zaman mudanya, dia sering dianggap lemah seperti sel-sel T muda yang lain, hanya berjaya menyempurnakan latihan melalui bantuan Sel T Pembantu, yang sekurang-kurangnya menjadikannya lebih kuat.
Sejenis sel yang bertanggungjawab membina semula tubuh daripada pelbagai kecederaan. Mereka digambarkan sebagai kanak-kanak kerana saiz mereka yang kecil dan bertindak sebagai pekerja pembinaan dan pembaikan di serata tubuh. Salah seorang daripadanya bertindak sebagai ketua dan sering ditampilkan dalam siri.
Sel T Pembantu (ヘルパーT細胞code: ja is deprecated , Herupā Tī Saibō)
Sejenis sel T yang merangka strategi dan tindakan semasa menangani serangan musuh. Dia merupakan komander utama bagi Sel T Pembunuh dan mempunyai pembawaan intelektual dan licik, menyebabkan dia sering berselisih dengan Sel T Pembunuh yang kasar dan bengis, walaupun kedua-dua mereka menghadiri kem latihan yang sama.
Sel T Pengawal (制御性T細胞code: ja is deprecated , Seigyosei Tī Saibō)
Sel T yang bertindak sebagai setiausaha Sel T Pembantu, meskipun dia berupaya untuk berlawan apabila perlu. Dia menghadiri kem latihan yang sama dengan Sel T Pembunuh dan Sel T Pembantu.
Sel T Naif (ナイーブT細胞code: ja is deprecated , Naību T saibō)
Sel T baharu yang terlalu takut untuk berlawan dengan kuman penakluk tubuh, sehinggalah Sel Dendrit membantunya untuk bertukar kepada Sel T Efektor. Dia dan rakan sejenisnya merupakan anak murid Sel T Pembunuh yang sering mendera mereka dengan latihan yang keras dan layanan yang kejam.
Sel T Efektor (エフェクターT細胞code: ja is deprecated , Efekutā T saibō)
Sel Naif yang bertukar kepada sel T yang besar, kuat dan berbadan sado. Rekaan watak dan kelakuannya merupakan parodi kepada pelbagai protagonis lelaki dalam JoJo's Bizarre Adventure.
Sejenis sel darah putih yang mengenali Sel Darah Putih memandangkan mereka membesar dalam sumsum tulang yang sama. Dia berasa tidak bernilai pada sel-sel keimunan yang lain kerana ketidakupayaannya melawan virus dan bakteria, tetapi dia menunjukkan keupayaannya yang sebenar dengan membunuh parasit Anisakis tatkala sel darah putih yang lain pula tidak mampu. Dia menggunakan lembing sebagai senjatanya..
Sel Dendrit (樹状細胞code: ja is deprecated , Jujō Saibō)
Digambarkan sebagai utusan berbaju hijau yang ditempatkan di pusat panggilan menyerupai sebatang pokok. Dia boleh merangsang Sel T Naif dan menukarkannya kepada Sel T Efektor.
Sel Ingatan (記憶細胞code: ja is deprecated , Kioku Saibō)
Sel neurotik yang paranoid yang mana tugasnya ialah mengingati jangkitan lepas dan alergi supaya sistem keimunan dapat bersedia. Namun, pemikirannya sering berserabut dan amat sukar baginya untuk menyusun ingatannya, sering panik dan menjerit setiap kali bencana datang.
Sel Tunjang (マスト細胞code: ja is deprecated , Masuto Saibō)
Sel yang tugasnya memantau dan melepaskan histamin sebagai tindak balas kepada reaksi alergi dan keradangan. Dia sering mengikuti arahan di dalam buku tidak kira apa jua situasi dan tidak popular kerana hilang pertimbangan terhadap tindakannya terhadap sel lain. Juga dikenali sebagai "sel gemuk", dia sering meradang setiap kal dia dirujuk dengan nama sedemikian.
Sel Darah Merah Senior (AA5100) (先輩赤血球code: ja is deprecated , Senpai Sekkekkyū)
Sel darah putih yang membawa senjata yang menembak antibodi. Dia sering meradang dan cemburu apabila tidak diberikan penghargaan sebagaimana Sel T Pembunuh. Dia juga mempunyai hubungan kurang baik dengan Sel Tunjang, memandangkan gabungan fungsi-fungsi mereka hanya mendatangkan bala bencana pada sel-sel lain.
Watak misteri lagi puitis yang pekerjaannya tidak diketahui, muncul setiap kali ada jangkitan bawaan makanan untuk memberikan ulasan tentang peristiwa yang berlaku.
Dia meronda seluruh tubuh untuk mengesan virus, bakteria dan sel abnormal, dengan bersenjatakan parang. Dia sering berkelakuan suka berlagak dan hubungannya dengan Sel T Pembunuh disamakan sebagai persaingan adik-beradik yang sengit.
Pencerita (ナレーションcode: ja is deprecated , Narēshon)
The manga was launched in Kodansha's shōnen manga magazine Monthly Shōnen Sirius in March 2015.[7] Kodansha has collected the manga into five tankōbon volumes setakat Oktober 2017[kemas kini].[8]
The manga received a spinoff in the May 2017 issue of Nakayoshi called Hataraku Saikin (はたらく細菌code: ja is deprecated ; "Bacteria at Work") by Haruyuki Kichida, which follows the lives of good and bad bacteria in the intestines.[9]
Another spinoff, titled Hatarakanai Saibō (はたらかない細胞code: ja is deprecated ; "Cells That Don't Work") by Moe Sugimoto, about immature red blood cells (erythroblasts) that do not want to work, was launched in the September 2017 issue of Monthly Shōnen Sirius.[10]Kodansha USA announced that it had licensed Cells at Work! in North America on March 21, 2016.[7] The manga is also licensed in Taiwan by Tong Li Publishing.[11]
The manga received another spinoff titled Hataraku Saibō Black (はたらく細胞 BLACKcode: ja is deprecated ), set in a "black" environment of a human body suffering an unhealthy lifestyle, that runs in Weekly Morning since June 7, 2018. It is written by Shigemitsu Harada, with illustrations by Issei Hatsuyoshi and supervision by Shimizu.[12]
An anime television series adaptation was announced in January 2018. It is directed by Kenichi Suzuki and animated by David Production, with scripts written by Suzuki and Yūko Kakihara, character designs by Takahiko Yoshida and music by Kenichirō Suehiro. The anime series premiered on July 7, 2018 on Tokyo MX and other channels.[5][24] The series will run for 13 episodes.[25]Aniplex of America have licensed the series in North America, and will simulcast it on Crunchyroll.[26] The opening theme is "Mission! Ken - Kō - Dai - Ichi" (ミッション! 健・康・第・イチcode: ja is deprecated , Mission! Health First) by Kana Hanazawa, Tomoaki Maeno, Daisuke Ono, and Kikuko Inoue,[5] while the ending theme is "CheerS" by ClariS.[27]
Inside a human body, a red blood cell, named AE3803, is rescued from a sudden attack from a group of Pneumococcus germs by a white blood cell, named U-1146. Later, as AE3803 tries to find her way to the lungs to make the delivery, she discovers one of the germs has escaped and is planning an attack on the lungs, so she and U-1146 accompany each other to the lungs to pursue it. Upon reaching the lungs and parting ways with U-1146, AE3803 discovers the germ had been hiding in her package the entire time, waiting to target red blood cells for their nutrients. However, U-1146, who had caught onto the germ's plan, arrives in time and lures the germ into a trap, where he is ultimately sneezed out of the lungs.
2
"Surikizu" (すり傷)
July 15, 2018
The red blood cells find themselves in trouble when the vessel they are traveling on is broken by a skin abrasion, with U-1146 and the other white blood cells forced to deal with all the germs that come through as a result. As the germs plot to eliminate all the neutrophils before backup can arrive, the white blood cells manage to hold them off while the platelets arrive to clot the wound, preventing more germs from getting through.
3
"Infuruenza" (インフルエンザ)
July 22, 2018
Naive T Cell is patrolling the body for influenza virus proliferation. But since he’s never taken on the enemy before, he’s completely terrified and useless. He finally ends up fleeing the battlefield, where U-1146 and the veteran Killer T Cells are fighting. Naive T Cell is filled with self-loathing until Dendritic Cell sees him and speaks to him kindly. This encouragement transforms him into Effector T Cell, a much braver and stronger form that joins the other immune cells in wiping out the influenza virus. However, a surviving virus mutates and proliferates, so the immune cells wearily prepare for battle again.
4
"Shokuchūdoku" (食中毒)
July 29, 2018
A band of Vibrio bacteria invades the stomach. Basophil warns the immune cells about it, but confuses everyone by speaking cryptically. The immune cells defeat the invaders, but one of them, Eosinophil, was unable to land any good hits and had to be rescued. The other cells mock her as a weakling, except AE3803 and U-1146. The stomach then gets invaded by a massive Anisakis parasite. The immune cells are no match for it, but Eosinophil explains she is designed to battle parasites and kills it with a single blow. The other cells apologize for making fun of her and praise her as a hero.
5
"Sugikafun Arerugī" (スギ花粉アレルギー)
August 5, 2018
The body inhales cedar pollen, which unleashes gigantic allergens. Though U-1146 points out the creatures are mindless and non-malicious, Memory Cell claims they bring impending doom. B Cell easily defeats the allergens, but Mast Cell releases Histamine into the body, which causes violent allergic reactions that damage the surroundings. Just as everyone blames Mast Cell for the destruction, the body takes a steroid to treat the allergy. The steroid appears in the form of a robot that indiscriminately destroys its surroundings until it runs out of power. The survivors realize all of this was caused by following Memory Cell's claims and trying to attack the allergens.
6
"Sekigakyū to Kotsuzuikyū" (赤芽球と骨髄球)
August 12, 2018
AE3803 gets lost again and finds herself in her homeland, the Red Bone Marrow. She reminisces on being a young Erythroblast being trained by a Macrophage on how to be a Red Blood Cell. One day, while practicing to evacuate from bacteria, she got lost and was separated from the others. She got captured by a Pseudomonas bacterium who intended to torture and kill her before moving on to other blood cells. A young Myelocyte came to her rescue, and although no match for the bacterium, bought enough time for Macrophage and a Neutrophil to arrive and kill the bacterium. She thanked the Myelocyte for helping her and they went their separate ways hoping to someday see each other again. In the present, she runs into U-1146. As he offers to guide her to her destination, she suspects the Myelocyte who saved her grew up to be U-1146.
Later, U-1146 saves a Normal Cell from a Cancer Cell. The Normal Cell explains there are more Cancer Cells in his apartment complex. The Normal Cell leads U-1146, Killer T Cell, and NK Cell to his apartment, but Killer T Cell and NK Cell continually butt heads and refuse to work together. The group splits up, and once they are alone, NK Cell reveals she knew the Normal Cell was actually a Cancer Cell in disguise.
7
"Gansaibō" (がん細胞)
August 19, 2018
NK Cell battles the Cancer Cell, who is able to shapeshift and spread into the surrounding environment. Meanwhile, U-1146 and Killer T Cell run into Cancer Cell's Multiplying Clones. The Cancer Cells order massive quantities of nutrients delivered to the apartment to sustain themselves, but AE3803 gets suspicious and alerts the rest of the immune system. U-1146, Killer T Cell, and NK Cell are cornered and about to be killed until the other immune cells arrive. The Cancer Cells are wiped out, but the Original Cell vows revenge before dying.
8
"Ketsueki Junkan" (血液循環)
August 26, 2018
AE3803 becomes tired of always getting lost and resolves to circulate the body without guidance. After a difficult journey, she manages to travel through the heart, then the lungs to exchange carbon dioxide with oxygen, then to the body's cells to exchange oxygen with carbon dioxide. U-1146 followed her and helped return her dropped notes and hat, then killed some germs who tried to ambush her, all without her noticing his presence. U-1146 later tells Killer T Cell that he has gained an appreciation for all the hard work the Red Blood Cells do every day and hopes the immune cells can live in harmony with other cells, but Killer T Cell punches him and orders him to get back to work. AE3803 meets U-1146 and tells him how her day went. Killer T Cell walks around seeing several immune cells mingling with other cells and angrily denies being jealous.
9
"Kyōsen Saibō" (胸腺細胞)
September 2, 2018
As Killer T Cell and Helper T Cell get into an argument about the former's training methods, Dendritic Cell shares his photo album with the Naive T Cells and explains the two's past. While training in the Thymus, the future Helper T Cell and Regulatory T Cell easily passed all the hand to hand combat and obstacle courses, but the future Killer T Cell struggled. The future Helper T Cell was disdainful of him for this, but eventually gave him advice that helped him pass the final test. Killer T Cell vowed to become a worthy defender of the body while Helper T Cell decided to become a commander. In the present, Killer T Cell and Helper T Cell notice the photo album. Embarrassed, they try unsuccessfully to take it from Dendritic Cell to destroy it. Regulatory T Cell muses that they are both as stupid as they were in training.
10
"Ōshoku Budō Kyūkin" (黄色ブドウ球菌)
September 9, 2018
AE3803 is rescued from a germ by a mysterious immune cell called Monocyte, who doesn't speak and wears a hazmat suit. Later, the nasal cavity gets invaded by a band of Staphylococcus aureus. Vowing revenge for one of their number who was killed in "Scrape Wound", they combine their bodies into a powerful giant who is able to trap the white blood cells in a net of fibrin. A squad of Monocytes appears and sheds their hazmat suits to reveal they are Macrophages; Monocytes being one of the many roles they play. The Macrophages easily defeat the invaders. As the white blood cells thank the Macrophages for saving everyone, AE3803 asks one of them how they fit their enormous dresses inside the hazmat suits, but she tells her it is a secret.
11
"Netchūshō" (熱中症)
September 16, 2018
The body suffers from heat stroke, leading to a heat wave in the cities and the supply of water being depleted. To make matters worse, a Bacillus cereus bacterium, who is not bothered by the heat, invades the body. While the other cells struggle to cope with the heat, U-1146 pursues the bacterium, but grows fatigued. Just when it seems that all is lost, the body gets an injection of fluids, reviving everyone and allowing U-1146 to defeat the bacterium.
12
"Shukketsusei Shokku (Zenpen)" (出血性ショック(前編))
Reception
Rebecca Silverman of Anime News Network highlighted the educational aspect of the manga despite flaws in presentation of information, and ultimately found the manga entertaining with likable characters.[28] Sean Gaffney of Manga Bookshelf called it a "very fun shonen action manga", complimenting the manga's ridiculousness and humor.[29]
The 2016 Kono Manga ga Sugoi! guidebook listed the manga as the seventh top manga for male readers.[30]Paul Gravett included the manga in his list of "Top 22 Comics, Graphic Novels & Manga" for October 2016.[31] As of July, 2017, the manga had over 1.3 million copies in print.[32] The manga had over 1.5 million copies in print as of January 2018.[33]
Dr. Satoru Otsuka, postdoctoral fellow in the molecular neuro-oncology department of Emory University School of Medicine in Atlanta, Georgia, praise the series' depiction of cancer cells during the series' seventh episode.[34] Biology teachers at a high school affiliated with China's Southwest University were so impressed with the accuracy of the series they assigned it as homework for their students.[35]