In most episodes, the word "sex" is spoken an average 25 times.
During the beginning of filming, Shailene Woodley had to wear a back brace to correct her scoliosis.
Molly Ringwald sings the show's theme song "Let's Do It, Let's Fall In Love" written by Cole Porter.
Shailene Woodley has said it was difficult to go to work in the later seasons because she disagreed so strongly with the show's views and the direction it was headed. If not contractually required, she would have left toward the end.
The series is made by the same producers as 7th Heaven. When Amy is soon to be in labor, she asks for a Dairy Shack burger, which is the same fast food restaurant in 7th Heaven.