Cruella De Vil quits smoking in this series.
Unlike the films, this series is set in the 1990s and features a more American setting with the characters (except for Cruella De Vil) having American accents.
As mentioned above, there were originally supposed to be five main characters: Lucky, Cadpig, Rolly, Patch, and Penny. Patch was relegated to the role of a minor character, and Penny does not appear in the series at all, as it was feared that there would be too many main characters. Spot was added in later.
Jasper & Horace in this series are voiced by Michael McKean and David L. Lander respectively. Both had previously been the voices of The Vultures Arthur & Cecil in Jungle Cubs (1996), a TV Spin-off to Another 1960s Animated Disney Film, The Jungle Book (1967). Both shows aired on ABC, as part of the network's One Saturday Morning lineup during the block's first season.
Lucky is the only character in the series to be voiced by two voice actresses: Pamela Adlon (who was also the voice of Ashley Spinelli on Recess (1997) and the voice of Vidia of the Disney Fairies) for the most part, and Debi Mae West whenever Pamela Adlon was unavailable.