This film is listed as a comedy, but it's not the "laugh out loud" type. In fact, there is some pretty serious subject matter involving a bank robbery, heroin addiction and the Japanese mafia. It's comparable to "Run Lola Run" in that yes, there is a lot of running! But it also shares "Lola's" non-linear story line. Some people may find this confusing. It's also similar in some respects to "Lock Stock and Two Smoking Barrels" as you learn (eventually) that all the characters introduced are connected in some way.
It helps to have some knowledge of the Asian culture (even if you learned it through Jackie Chan movies). The Asian's emphasis on honor and saving face is a key driving force for these characters. The relationship between the yakuza/mafia guys and their boss/master is laughable to an American sensibility. The motivations these guys have to run all over town in a marathon chase would never work in this country.
If you can be patient and wait it out, the plot will fall into place. If you don't like movies you have to figure out, or if you get lost during flashbacks, you probably won't enjoy this one. Don't expect a knee-slapper, but there are a few good chuckles (some probably unintended) and interesting plot twists.
P.S. If shaky hand-held camera work a la "Blair Witch" makes you queasy, beware!