HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

• Bastien Mangeat,

  Affiliations Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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• Gustavo Gers-Huber,

  Affiliations Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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• Martin Lehmann,

  Affiliations Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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• Madeleine Zufferey,

  Affiliation Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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• Jeremy Luban,

  Affiliation Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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• Vincent Piguet

  * E-mail: [email protected]

  Affiliations Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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