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'''Korean Genome Project''' (KGP) is the largest Korean [[Genome project|Genome Project]] which currently includes 10,000 human genomes sequenced in [[Korea]]. KGP was originated from the national initiative of sequencing the reference Korean and whole population genomes in 2006 by [[Korean Bioinformation Center|KOBIC]], [[Korea Research Institute of Bioscience and Biotechnology|KRIBB]] and [[NCSRD]], KRISS, Daejeon in Korea. From 2009, KGP was supported by the [[Genome Research Foundation]] and TheragenEtex to build the [[Variome]] of Koreans as well as the Korean Reference Genome ([[KOREF]]). Starting from KOREF, a consensus variome reference, providing information on millions of variants from 40 additional ethnically homogeneous genomes from the Korean [[Personal Genome Project]] was completed in 2017.<ref>{{Cite journal|last=Cho|first=Yun Sung|last2=Kim|first2=Hyunho|last3=Kim|first3=Hak-Min|last4=Jho|first4=Sungwoong|last5=Jun|first5=JeHoon|last6=Lee|first6=Yong Joo|last7=Chae|first7=Kyun Shik|last8=Kim|first8=Chang Geun|last9=Kim|first9=Sangsoo|last10=Eriksson|first10=Anders|last11=Edwards|first11=Jeremy S.|date=2016-11-24|title=An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes|url=https://www.nature.com/articles/ncomms13637|journal=Nature Communications|language=en|volume=7|issue=1|pages=1–13|doi=10.1038/ncomms13637|issn=2041-1723|doi-access=free}}</ref> Updating the technology an improved version of KOREF was then constructed using [[long-read sequencing]] data produced by [[Oxford Nanopore Technologies|Oxford Nanopore]] PromethION and [[Pacific Biosciences|PacBio]] technologies has been released showcasing newer assembly technologies and techniques.<ref>{{Cite journal|last=Kim|first=Hui-Su|last2=Jeon|first2=Sungwon|last3=Kim|first3=Changjae|last4=Kim|first4=Yeon Kyung|last5=Cho|first5=Yun Sung|last6=Kim|first6=Jungeun|last7=Blazyte|first7=Asta|last8=Manica|first8=Andrea|last9=Lee|first9=Semin|last10=Bhak|first10=Jong|date=2019-12-01|title=Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information|url=https://academic.oup.com/gigascience/article/8/12/giz125/5651108|journal=GigaScience|language=en|volume=8|issue=12|doi=10.1093/gigascience/giz125|pmc=6889754|pmid=31794015}}</ref> Since 2014, KGP has been supported by [[Ulsan National Institute of Science and Technology]], Clinomics, and Ulsan City, Ulsan, Korea. KGP released 1,094 Korean whole genome sequences on 27th May 2020 in Science Advances<ref>{{Cite journal|last=Jeon|first=Sungwon|last2=Bhak|first2=Youngjune|last3=Choi|first3=Yeonsong|last4=Jeon|first4=Yeonsu|last5=Kim|first5=Seunghoon|last6=Jang|first6=Jaeyoung|last7=Jang|first7=Jinho|last8=Blazyte|first8=Asta|last9=Kim|first9=Changjae|last10=Kim|first10=Yeonkyung|last11=Shim|first11=Jungae|date=2020-05-01|title=Korean Genome Project: 1094 Korean personal genomes with clinical information|url=https://advances.sciencemag.org/content/6/22/eaaz7835|journal=Science Advances|language=en|volume=6|issue=22|pages=eaaz7835|doi=10.1126/sciadv.aaz7835|issn=2375-2548}}</ref>.
'''Korean Genome Project''' (KGP) is the largest Korean [[Genome project|Genome Project]] which currently includes 10,000 human genomes sequenced in [[Korea]]. KGP was originated from the national initiative of sequencing the reference Korean and whole population genomes in 2006 by [[Korean Bioinformation Center|KOBIC]], [[Korea Research Institute of Bioscience and Biotechnology|KRIBB]] and [[NCSRD]], KRISS, Daejeon in Korea. From 2009, KGP was supported by the [[Genome Research Foundation]] and TheragenEtex to build the [[Variome]] of Koreans as well as the Korean Reference Genome ([[KOREF]]). Starting from KOREF, a consensus variome reference, providing information on millions of variants from 40 additional ethnically homogeneous genomes from the Korean [[Personal Genome Project]] was completed in 2017.<ref>{{Cite journal|last=Cho|first=Yun Sung|last2=Kim|first2=Hyunho|last3=Kim|first3=Hak-Min|last4=Jho|first4=Sungwoong|last5=Jun|first5=JeHoon|last6=Lee|first6=Yong Joo|last7=Chae|first7=Kyun Shik|last8=Kim|first8=Chang Geun|last9=Kim|first9=Sangsoo|last10=Eriksson|first10=Anders|last11=Edwards|first11=Jeremy S.|date=2016-11-24|title=An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes|url=https://www.nature.com/articles/ncomms13637|journal=Nature Communications|language=en|volume=7|issue=1|pages=1–13|doi=10.1038/ncomms13637|issn=2041-1723|doi-access=free}}</ref> Updating the technology an improved version of KOREF was then constructed using [[long-read sequencing]] data produced by [[Oxford Nanopore Technologies|Oxford Nanopore]] PromethION and [[Pacific Biosciences|PacBio]] technologies has been released showcasing newer assembly technologies and techniques.<ref>{{Cite journal|last=Kim|first=Hui-Su|last2=Jeon|first2=Sungwon|last3=Kim|first3=Changjae|last4=Kim|first4=Yeon Kyung|last5=Cho|first5=Yun Sung|last6=Kim|first6=Jungeun|last7=Blazyte|first7=Asta|last8=Manica|first8=Andrea|last9=Lee|first9=Semin|last10=Bhak|first10=Jong|date=2019-12-01|title=Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information|url=https://academic.oup.com/gigascience/article/8/12/giz125/5651108|journal=GigaScience|language=en|volume=8|issue=12|doi=10.1093/gigascience/giz125|pmc=6889754|pmid=31794015}}</ref> Since 2014, KGP has been supported by [[Ulsan National Institute of Science and Technology]], Clinomics, and Ulsan City, Ulsan, Korea. KGP released 1,094 Korean whole genome sequences on 27th May 2020 in Science Advances<ref>{{Cite journal|last=Jeon|first=Sungwon|last2=Bhak|first2=Youngjune|last3=Choi|first3=Yeonsong|last4=Jeon|first4=Yeonsu|last5=Kim|first5=Seunghoon|last6=Jang|first6=Jaeyoung|last7=Jang|first7=Jinho|last8=Blazyte|first8=Asta|last9=Kim|first9=Changjae|last10=Kim|first10=Yeonkyung|last11=Shim|first11=Jungae|date=2020-05-01|title=Korean Genome Project: 1094 Korean personal genomes with clinical information|url=https://advances.sciencemag.org/content/6/22/eaaz7835|journal=Science Advances|language=en|volume=6|issue=22|pages=eaaz7835|doi=10.1126/sciadv.aaz7835|issn=2375-2548}}</ref>.

Revision as of 06:52, 1 June 2020

Korean Genome Project (KGP) is the largest Korean Genome Project which currently includes 10,000 human genomes sequenced in Korea. KGP was originated from the national initiative of sequencing the reference Korean and whole population genomes in 2006 by KOBIC, KRIBB and NCSRD, KRISS, Daejeon in Korea. From 2009, KGP was supported by the Genome Research Foundation and TheragenEtex to build the Variome of Koreans as well as the Korean Reference Genome (KOREF). Starting from KOREF, a consensus variome reference, providing information on millions of variants from 40 additional ethnically homogeneous genomes from the Korean Personal Genome Project was completed in 2017.[1] Updating the technology an improved version of KOREF was then constructed using long-read sequencing data produced by Oxford Nanopore PromethION and PacBio technologies has been released showcasing newer assembly technologies and techniques.[2] Since 2014, KGP has been supported by Ulsan National Institute of Science and Technology, Clinomics, and Ulsan City, Ulsan, Korea. KGP released 1,094 Korean whole genome sequences on 27th May 2020 in Science Advances[3].

KGP consortium

The final Goal of KGP aims to sequence ~85,000,000 Koreans. I.e, every ethnic Korean on Earth.

References

  1. ^ Cho, Yun Sung; Kim, Hyunho; Kim, Hak-Min; Jho, Sungwoong; Jun, JeHoon; Lee, Yong Joo; Chae, Kyun Shik; Kim, Chang Geun; Kim, Sangsoo; Eriksson, Anders; Edwards, Jeremy S. (2016-11-24). "An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes". Nature Communications. 7 (1): 1–13. doi:10.1038/ncomms13637. ISSN 2041-1723.
  2. ^ Kim, Hui-Su; Jeon, Sungwon; Kim, Changjae; Kim, Yeon Kyung; Cho, Yun Sung; Kim, Jungeun; Blazyte, Asta; Manica, Andrea; Lee, Semin; Bhak, Jong (2019-12-01). "Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information". GigaScience. 8 (12). doi:10.1093/gigascience/giz125. PMC 6889754. PMID 31794015.
  3. ^ Jeon, Sungwon; Bhak, Youngjune; Choi, Yeonsong; Jeon, Yeonsu; Kim, Seunghoon; Jang, Jaeyoung; Jang, Jinho; Blazyte, Asta; Kim, Changjae; Kim, Yeonkyung; Shim, Jungae (2020-05-01). "Korean Genome Project: 1094 Korean personal genomes with clinical information". Science Advances. 6 (22): eaaz7835. doi:10.1126/sciadv.aaz7835. ISSN 2375-2548.


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