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Ninein

From Wikipedia, the free encyclopedia
NIN
Identifiers
AliasesNIN, SCKL7, ninein
External IDsOMIM: 608684; MGI: 105108; HomoloGene: 40632; GeneCards: NIN; OMA:NIN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016350
NM_020921
NM_182944
NM_182945
NM_182946

NM_001081453
NM_001286079
NM_001286080
NM_008697

RefSeq (protein)

NP_057434
NP_065972
NP_891989
NP_891991

NP_001074922
NP_001273008
NP_001273009
NP_032723
NP_001390761

Location (UCSC)Chr 14: 50.72 – 50.83 MbChr 12: 70.06 – 70.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ninein is a protein that in humans is encoded by the NIN gene.[5][6][7]

Function

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Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[7]

This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100503Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021068Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
  6. ^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.
  7. ^ a b c "Entrez Gene: NIN ninein (GSK3B interacting protein)".

Further reading

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