Sovateltide
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(Redirected from IRL-1620)
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Trade names | Tyvalzi |
Other names | IRL-1620; PMZ-1620 |
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Formula | C86H117N17O27 |
Molar mass | 1820.974 g·mol−1 |
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Sovateltide (development names IRL-1620 and PMZ-1620,[1] sold in India under the brand name Tyvalzi)[2] is a synthetic analog of endothelin-1 that works as a selective endothelin-B receptor agonist. In May 2023, it was approved in India to treat acute ischemic stroke. The drug was developed by Pharmazz.[2] Sovateltide stimulates neural progenitor cells in the brain and promotes neurovascular remodeling by forming new neurons (neurogenesis) and blood vessels (angiogenesis).[3][4] Sovateltide also protects neural mitochondria and enhances their biogenesis.[5]
References
[edit]- ^ Gulati, Anil; Agrawal, Nilesh; Vibha, Deepti; Misra, U. K.; Paul, Birinder; Jain, Dinesh; Pandian, Jeyaraj; Borgohain, Rupam (January 2021). "Safety and Efficacy of Sovateltide (IRL-1620) in a Multicenter Randomized Controlled Clinical Trial in Patients with Acute Cerebral Ischemic Stroke". CNS Drugs. 35 (1): 85–104. doi:10.1007/s40263-020-00783-9. ISSN 1179-1934. PMC 7872992. PMID 33428177.
- ^ a b Keam, Susan J. (September 2023). "Sovateltide: First Approval". Drugs. 83 (13): 1239–1244. doi:10.1007/s40265-023-01922-4. ISSN 1179-1950. PMID 37486545. S2CID 260114948.
- ^ Ranjan, Amaresh K.; Gulati, Anil (2022-03-15). "Sovateltide Mediated Endothelin B Receptors Agonism and Curbing Neurological Disorders". International Journal of Molecular Sciences. 23 (6): 3146. doi:10.3390/ijms23063146. ISSN 1422-0067. PMC 8955091. PMID 35328566.
- ^ Ranjan, Amaresh K.; Briyal, Seema; Khandekar, Divya; Gulati, Anil (September 2020). "Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke". Canadian Journal of Physiology and Pharmacology. 98 (9): 659–666. doi:10.1139/cjpp-2020-0164. ISSN 0008-4212. PMID 32574518.
- ^ Ranjan, Amaresh K.; Briyal, Seema; Gulati, Anil (2020-07-29). "Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke". Scientific Reports. 10 (1): 12737. Bibcode:2020NatSR..1012737R. doi:10.1038/s41598-020-69673-w. ISSN 2045-2322. PMC 7391684. PMID 32728189.