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3 January 2023

24 December 2022

22 December 2022

18 August 2022

  • 00:3200:32, 18 August 2022 diff hist +46 Phenazocine Added reference to potency of (S) phenazocine.
  • 00:2700:27, 18 August 2022 diff hist +128 Phenazocine Phenazocine has 2 isomers. The (R) isomers is about x20 morphine in potency while the (S) isomer is about x4 morphine in potency. Presuming that the commercial product is a racemic mixture, a figure of x10 morphine is given by many sources. I can add more references but hoped someone has a reference in which the two isomers are compared.

24 June 2022

29 May 2022

30 April 2022

17 February 2022

  • 00:3200:32, 17 February 2022 diff hist +9 Phenampromide I am unsure as to the exact notation sought by Wiki. The -OH overlays the beta hydroxy moiety of related fentanyl analogues. Technically it's a 4-piperidinol, but is that of utility to readers? I am looking for and intend to include the appropriate Janssen papers but they are elusive. I would appreciate help on this. The book merely says that it IS Janssen... but nothing more. I think BBC reference is in order (3 creditable references). I would hope 2 is acceptable, but prefer to get it right.

16 February 2022

  • 14:5314:53, 16 February 2022 diff hist +203 Phenampromide Added reference to the 4-OH derivative of the 4-phenyl derivative/ It increases potency of the racemate to x150 morphine. This is an achiral derivative. It's also worth noting that adding a 3-methyl to the piperidine increases potency as does a 3,3-dimethyl. I do not think anyone has combined all of these features.

15 February 2022

8 February 2022

4 February 2022

29 January 2022

28 January 2022

23 October 2021

20 October 2021

  • 17:5517:55, 20 October 2021 diff hist −1 Tilidine Fixed spelling mistake in patent name from 'Cycloaliphatic compounds, analgesic compositionss thereof and method of use thereof as analgesics'

12 September 2021

19 August 2021

13 November 2020

17 May 2010