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PRIM2

From Wikipedia, the free encyclopedia
PRIM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDsOMIM: 176636; MGI: 97758; HomoloGene: 731; GeneCards: PRIM2; OMA:PRIM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000947
NM_001282487
NM_001282488

NM_008922

RefSeq (protein)

NP_000938
NP_001269416
NP_001269417

NP_032948

Location (UCSC)Chr 6: 57.31 – 57.65 MbChr 1: 33.49 – 33.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[5][6]

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146143Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026134Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.
  6. ^ a b "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa".

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA primase large subunit (PRIM2)