Phosphomevalonate kinase
Appearance
Phosphomevalonate kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.4.2 | ||||||||
CAS no. | 9026-46-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phosphomevalonate kinase | |||||||
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Identifiers | |||||||
Symbol | PMVK | ||||||
NCBI gene | 10654 | ||||||
HGNC | 9141 | ||||||
OMIM | 607622 | ||||||
RefSeq | NM_006556 | ||||||
UniProt | Q15126 | ||||||
Other data | |||||||
EC number | 2.7.4.2 | ||||||
Locus | Chr. 1 p13-q23 | ||||||
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Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway[5][6][7] that in humans is encoded by the PMVK gene.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Mevalonate_pathway.png/350px-Mevalonate_pathway.png)
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163344 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027952 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bloch K, Chaykin S, Phillips AH, De Waard A (October 1959). "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry. 234 (10): 2595–604. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508.
- ^ Henning U, Moslein EM, Lynen F (July 1959). "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics. 83 (1): 259–67. doi:10.1016/0003-9861(59)90031-1. PMID 13662013.
- ^ Levy HR, Popjak G (June 1960). "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal. 75 (3): 417–28. doi:10.1042/bj0750417. PMC 1204488. PMID 14416398.
External links
- Phosphomevalonate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q15126 (Phosphomevalonate kinase) at the PDBe-KB.