Talk:Dizocilpine

Olney's lesions?

The article sats this: "MK-801 had a promising future as a neuroprotective agent until neurotoxic-like effects were seen in certain brain regions." Does this have to do with Olney's lesions or something else? If so, I can cite this, but otherwise, we need a citation for this. Jolb 21:34, 7 January 2007 (UTC)[reply]

The harm I know of that MK801 causes is neurovacuolization. And there could be other studies that found toxicity. I know MK801 didn't do too hot in clinical trials because it has poor tolerability, e.g. causing intense, unpleasant aural hallucinations. Here's the ref I've found for the vacuolization thing, I'll go ahead and add it in:

Olney J, Labruyerre J and Price MT. 1989. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Sciencel, Volume 244, Issue 4910, Pages 1360-1362. Accessed January 7, 2006.