Anne Plant
Anne L. Plant is an American biologist.
Education
Plant completed a B.A. with university scholarship honors in biology with minors in math and chemistry in 1976 at University of Arizona. In 1978, she earned a M.S. in human nutrition from University of Nebraska–Lincoln under advisor Constance Kies. Her thesis was titled, The effect of copper and fiber supplementation on copper utilization in humans. Plant earned a Ph.D. in biochemistry from Baylor College of Medicine in 1983. Her doctoral advisor was Louis C. Smith. Plant's dissertation was titled Aqueous phase transfer of polycyclic aromatic hydrocarbons in model membranes and cells.[1]
Research
Plant's branch researches single-cell measurements from live cell microscopy, and development of theoretical approaches that lead to predictive understanding of complex cellular systems. Currently, Plant examines small molecular networks in engineered induced pluripotent stem cells with a statistical thermodynamics model. The heterogeneity of cellular phenotypes within isogenic populations provides a window into the diversity of ways the cellular machinery can operate to process information. This diversity of expression reflects the stochastic fluctuations that occur as connected network variables interact with one another to effect up- and down-regulation. Plant's lab goals include to measure the kinetic constants for those fluctuations, and the correlations between them, to provide a thermodynamic basis for understanding which cellular measurands are the most important for controlling a particular phenotype. This work is motivated by a critical challenge in characterizing cell-based therapies, namely what should be measured that will provide predictive information about the cell product to assure desirable functionality. Carrying out this study involves a large number of NIST collaborators to address challenges in rapid non-perturbing quantitative imaging, CRISPR-Cas genome editing of reporter iPSC lines, image analysis including the use of CNN inference, and theoretical modeling.[1]
References
- ^ a b Plant, Anne L. (2019-10-09). "Anne L Plant". NIST. Retrieved 2019-11-12.
This article incorporates text from this source, which is in the public domain.
External links
- Anne Plant publications indexed by Google Scholar
- Living people
- University of Arizona alumni
- University of Nebraska–Lincoln alumni
- Baylor College of Medicine alumni
- 20th-century American biologists
- 21st-century American biologists
- 20th-century women scientists
- 21st-century women scientists
- American women biologists
- National Institute of Standards and Technology people