Cyclin-dependent kinase inhibitor protein
| Cyclin-dependent kinase inhibitor | |||||||||||
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 Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | CDI | ||||||||||
| Pfam | PF02234 | ||||||||||
| InterPro | IPR003175 | ||||||||||
| SCOP2 | 1jsu / SCOPe / SUPFAM | ||||||||||
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A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several function as tumor suppressor proteins. Cell cycle progression is negatively controlled by cyclin-dependent kinase inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G1 phase.
Examples
References
- ^ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
- ^ Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.
External links
- Cyclin-Dependent+Kinase+Inhibitor+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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