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Cyclin-dependent kinase inhibitor protein

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Cyclin-dependent kinase inhibitor
Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1]
Identifiers
SymbolCDI
PfamPF02234
InterProIPR003175
SCOP21jsu / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1jsuC:30-80 1h27E:30-35

A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several function as tumor suppressor proteins. Cell cycle progression is negatively controlled by cyclin-dependent kinase inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G1 phase.

Examples

Protein Gene Interacts with
p16 CDKN2A Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15 CDKN2B Cyclin-dependent kinase 4
p18 CDKN2C Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19 CDKN2D Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1 CDKN1A[2] Cyclin E1/Cyclin-dependent kinase 2
p27 CDKN1B Cyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57 CDKN1C Cyclin E1/Cyclin-dependent kinase 2
CDKN3 Cyclin-dependent kinase 2

References

  1. ^ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
  2. ^ Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.