Compounding
Template:Globalize/USA Pharmaceutical compounding (done in compounding pharmacies) is the creation of a particular pharmaceutical product to fit the unique needs of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s). It may also be done for more optional reasons, such as adding flavors to a medication or otherwise altering taste or texture. Compounding is most routine in the case of intravenous/parenteral medication, typically by hospital pharmacists, but is also offered by privately owned compounding pharmacies and certain retail pharmacies for various forms of medication. Whether routine or rare, intravenous or oral, etc., when a given drug product is made or modified to have characteristics that are specifically prescribed for an individual patient – it is known as "traditional" compounding.
Due to rising cost of compounding and shortage of drugs in recent times, many hospitals have shown a tendency to rely more upon large-scale compounding pharmacies to meet their regular requirement, particularly of sterile-injectable medications. When "compounding" is done on bulk production of a given formulation rather than patient-specific production, it is known as "non-traditional" compounding(which as discussed below, is arguably not "compounding" but rather "manufacturing") This development raises concerns about safety and calls for proper regulatory control and monitoring.[1] .[1]
History
This section needs additional citations for verification. (July 2010) |
Before mass production of medications became widespread, compounding was a routine activity among pharmacists. Community pharmacists who have experience with compounding techniques are now less common.
Pharmaceutical compounding has ancient roots. Hunter-gatherer societies had some knowledge of the medicinal properties of the animals, plants, molds, fungus and bacteria as well as inorganic minerals within their environment. Ancient civilizations used pharmaceutical compounding for religion, grooming, keeping the healthy well, treating the ill and preparing the dead. These ancient compounders produced the first oils from plants and animals. They discovered poisons and the antidotes. They made ointments for wounded patients and perfumes for customers.
The earliest chemists were familiar with various natural substances and their uses. These drug artisans compounded a variety of preparations such as medications, dyes, incense, perfumes, ceremonial compounds, preservatives and cosmetics. Drug compounders seeking gold and the fountain of youth drove the alchemy movement. Alchemy eventually contributed to the creation of modern pharmacy and the principles of pharmacy compounding. In the medieval Islamic world in particular, Muslim pharmacists and chemists developed advanced methods of compounding drugs. The first drugstores were opened by Muslim pharmacists in Baghdad in 754.[2][3]
The modern age of pharmacy compounding began in the 19th century with the isolation of various compounds from coal tar for the purpose of producing synthetic dyes. From this one natural product came the earliest antibacterial sulfa drugs, phenolic compounds made famous by Joseph Lister, and plastics.
During the 1800s, pharmacists specialized in the raising, preparation and compounding of crude drugs. Crude drugs, like opium, are from natural sources and usually contain several chemical compounds. The compounding pharmacist often extracted these crude drugs using water or alcohol to form extracts, concoctions and decoctions.
Pharmacists began isolating and identifying the active ingredients contained within these crude drug concoctions. Using fractionation or recrystallization, the compounding pharmacist would separate the active ingredients, like morphine, and use it in place of the crude drug. During this time modern medicine began.
With the isolation of medications from the “raw materials” or crude drugs came the birth of the modern pharmaceutical company. Pharmacists were trained to compound the preparations made by the drug companies, but they could not do it efficiently on a small scale. So economies of scale, not lack of skill or knowledge, produced a market for the modern pharmaceutical drug companies.
With the turn of the 20th century came greater government regulation of the practice of medicine. These new regulations forced the drug companies to prove that any new medication they brought to market was safe. With the discovery of penicillin, modern marketing techniques and brand promotion, the drug manufacturing industry came of age. Pharmacists continued to compound most prescriptions until the early 1950s when the majority of dispensed drugs came directly from the large pharmaceutical companies.
Roles
During research and development
Pharmaceutical compounding is a branch of pharmacy that continues to play the crucial role of drug development. Compounding pharmacists and medicinal chemists develop and test combinations of active pharmaceuticals and delivery systems for new pharmaceutical formulations so that the active ingredients are effective, stable, easy to use, and acceptable to patients. However, for actual clinical trials, production of drug products is generally considered "manufacturing" because "compounding" is typically defined as being for small batch or single individual patient production only.
Patients with unique or unusual medication needs
Physicians may prescribe an individually compounded medication for a patient with an unusual health need. This allows the physician to tailor a prescription to each individual. Compounding preparations are especially prevalent for:
- Patients requiring limited dosage strengths, such as a very small dose for infants
- Patients requiring a different formulation, such as turning a pill into a liquid or transdermal gel for people who cannot swallow pills due to disability
- Patients requiring an allergen-free medication, such as one without gluten or colored dyes
- Patients who absorb or excrete medications abnormally[4]
- Patients who need drugs that have been discontinued by pharmaceutical manufacturers because of low profitability
- Patients facing a supply shortage of their normal drug[5][6]
- Children who want flavored additives in liquid drugs, usually so that the medication tastes like candy or fruit
- Veterinary medicine, for a change in dose, change to a more easily-administered form (such as from a pill to a liquid or transdermal gel), or to add a flavor more palatable to the animal. In the United States, compounded veterinary medicine must meet the standards set forth in the Animal Medicinal Drug Use Clarification Act (AMDUCA)[4][7]
- Many types of bioidentical hormone replacement therapy[8]
Personalized medicine and polypharmacy
While the regulatory boundaries are not always clear (see "Regulation"), there is general acceptance of the need for physicians to have wide discretion to prescribe customized drug products containing unique drug-dosage combinations and/or formulations thereof specifically for individual patients. Most mass-produced drugs often have only one or two readily available dosage levels (except the most dominant drugs), and fixed-dose combination products – despite their many benefits – are even less likely to have the optimal combination of drugs and respective dosages for any given patient. Hence, the opportunity to tailor the drug(s)/dosage(s) in a given drug product as specifically contemplated for individual patients (as deemed optimal by one's physician) is an application of the classic principles underlying compounding.
Some kinds or compositions of "polypills" or other drug products are more amenable to custom-compounding than others, and most retail pharmacies no longer offer compounding services at all (although hospital pharmacies still commonly compound intravenous medications). But while fewer pharmacists are trained and experienced in the relevant skills anymore, especially regarding oral dosage forms (which are almost always mass-produced now instead), such compounding pharmacies nevertheless can be found and utilized via mail-order (if not available locally) with sufficient notice and planning.[9]
Technologies are under development to facilitate production of customized polypills, such as for example by the use of ink-jet printing mechanisms to precisely deposit selected drug substance(s) onto sheets which can then be inserted into capsules (enabling "individualized dosing and automated fabrication of medicines containing multiple drugs," in addition to custom single-drug products).[10][11][12] Similar technology can also be used to print tablets, more directly. Ink-jet or fluid-jet approaches do require each drug substance to be dissolved in a liquid solvent, but they can be particularly conducive to custom formulation with various possible excipients (in addition to custom drug/dose selections).
Regulation in the United States
In the United States, compounding pharmacies are licensed and regulated by their respective state like all other pharmacies. National standards have been created by Pharmacy Compounding Accreditation Board (PCAB).[13] However, accreditation is not mandatory and inspections for compliance occur only every three years.[14] A major source of opposition to new FDA regulation on compounding stems from certain dietary supplement makers.[15] Notably, the FDA has always had authority to regulate "manufacturing" – which is when drug products are not made or modified as to be tailored in some way to the individual patient – regardless of whether this is done at a factory or at a pharmacy. And conversely, truly legitimate/traditional compounding does not cease to be so merely by having a high frequency or occurrence – indeed, progressing towards more prevalent drug product customization is an appealing aspect of personalized medicine (see above).
Compounding pharmacies were the subject of the United States Supreme Court decision Thompson v. Western States Medical Center (535 U.S. 357, 2002),[16] which held that Congressional attempts to restrict advertising by compounding pharmacies were unconstitutional. However, the same statute (FDAMA, amending the Federal Food, Drug, and Cosmetic Act which establishes the U.S. Food and Drug Administration (FDA)) also contained a provision that largely exempted compounded products from the FDA's control by defining many of them as not being "new drugs" for FDA purposes. Since the Supreme Court did not rule on the issue of how broadly to interpret that provision, nor on the issue of whether that provision was "severable" from the struck provision, there remains today a Circuit-split on both of those questions: As of 2008, the 9th Circuit (binding in several western states) holds that the provisions are not severable, and hence section 503A of the FDAMA is void; on the other hand, the 5th Circuit (binding in several southwestern states) holds that the provisions are severable, and hence the non-struck portions of the FDAMA remain intact (including what it interpreted to be a limited exemption from FDA reach for any compounded drugs that meet the requirements given in the statute).
Meanwhile, in Circuits where the FDAMA is void and thus the FDA retains its original reach, the FDA weighs the following (non-exhaustive) mix of factors in deciding whether to "exercise its discretion" to require approval for a custom-compounded drug product, from its 2002 Compliance Policy Guide on the matter:[17]
- Compounding in anticipation of receiving prescriptions,
- Compounding drugs removed from the market for safety reasons,
- Compounding from bulk ingredients not approved by FDA,
- Receiving, storing, or using drugs not made in an FDA-registered facility,
- Receiving, storing, or using drugs' components not determined to meet compendia requirements,
- Using commercial-scale manufacturing or testing equipment,
- Compounding for third parties for resale,
- Compounding drugs that are essentially the same as commercially available products,
- Failing to operate in conformance with applicable state law.
Hence, making truly patient-customized products with particular drug(s)/dosage(s) upon receiving valid prescriptions from a physician is likely to be acceptable, especially if the ingredients are FDA approved, etc.
Also from the 2002 CPG document, the FDA assures compounding pharmacies that its main concern is those who effectively engage in multi-patient "manufacturing" under the guise of compounding. "FDA recognizes that pharmacists traditionally have extemporaneously compounded and manipulated reasonable quantities of human drugs upon receipt of a valid prescription for an individually identified patient from a licensed practitioner. This traditional activity is not the subject of this guidance."[18]
Analogy to "off-label" use
As a related point regarding the broad professional discretion to customize patient care, note that about 20–30% of prescription medications in the US are estimated to be used "off-label," meaning the physician believes the drug to be beneficial for a patient despite its not being approved for that particular use/condition. This too is perfectly legal, subject only to state regulations on the practice of medicine, etc.
The appropriateness or the legality of prescribing approved drugs for uses not included in their official labeling is sometimes a cause of concern and confusion among physicians. This concern has been addressed by the American Society of Health-System Pharmacists in their Statement on the Use of Medications for Unlabeled Uses:[19] Under the Federal Food, Drug and Cosmetic (FD&C) Act, a drug approved for marketing may be labeled, promoted, and advertised by the manufacturer only for those uses for which the drug's safety and effectiveness has been established and which the FDA has approved. These are commonly referred to as "approved uses." This means that adequate and well-controlled clinical trials have documented these uses, and the results of the trials have been reviewed and approved by the FDA.
The FD&C Act does not, however, limit the manner in which a physician may use an approved drug. Once a product has been approved for marketing, a physician may prescribe it for uses or in treatment regimens or patient populations that are not included in the above labeling. Such "unapproved" or more precisely, "unlabeled" uses may be appropriate and rational in certain circumstances, and, may, in fact, reflect approaches to drug therapy that have been extensively reported in medical literature.
The term "unapproved uses" is, to some extent, misleading. Valid new uses for drugs already on the market are often first discovered through serendipitous observations and therapeutic investigations. Before such advances can be added to the approved labeling, however, data substantiating the effectiveness of a new use or regimen must be submitted by the manufacturer to the FDA for evaluation. This may take time and without the initiative of the drug manufacturer whose product is involved, may never occur. For that reason, accepted medical practice often includes drug use that is not reflected in approved drug labeling.
With respect to its role in medical practice, the package insert is informational only. The FDA tries to assure that prescription drug information in the package insert accurately and fully reflects the data on safety and effectiveness on which drug approval is based.[19]
Drug testing and reporting of incidents
Poor practices on the part of drug compounders can result in contamination or in products that don't possess the strength, quality, and purity required. Unless a complaint is filed or a patient is harmed, drugs made by compounders are seldom tested, In Texas, one of only two states that does random testing, significant problems have been found. Random tests by the state’s pharmacy board over the last several years have found that as many as one in four compounded drugs was either too weak or too strong. In Missouri, the only other state that does testing, potency varied by as much as 300 percent.[20]
In 2002, the FDA, concerned about the rising number of accidents related to compounded medications, identified "red flag" factors and issued a guide devoted to human pharmacy compounding, These factors include instances where pharmacists are:
- Compounding drug products that have been pulled from the market because they were found to be unsafe or ineffective.
- Compounding drugs that are essentially copies of a commercially available drug product.
- Compounding drugs in advance of receiving prescriptions, except in very limited quantities relating to the amounts of drugs previously compounded based on valid prescriptions.
- Compounding finished drugs from bulk active ingredients that aren't components of FDA-approved drugs, without an FDA-sanctioned, investigational new-drug application.
- Receiving, storing, or using drug substances without first obtaining written assurance from the supplier that each lot of the drug substance has been made in an FDA-registered facility.
- Failing to conform to applicable state law regulating the practice of pharmacy.[21]
In recent years raw materials are increasingly obtained from foreign suppliers. Large drug companies which are FDA inspected must keep careful track of who has handled their raw materials while compounding pharmacies, some so large that they resemble commercial manufacturers, are not bound by similar guidelines. In 2011 the FDA was concerned about the suspected use of unapproved Chinese ingredients in an injectable medication used to reduce the risk of premature birth, but they were refused a sample for testing. Instead, the trade group, the International Academy of Compounding Pharmacists, suggested in an email to the compounding pharmacy that they respond to any request for samples by saying: “We do not compound or distribute ‘samples’ of any of our prescription medications to anyone.” They went on to advise that if the drug was on the premises, a pharmacist should say it was awaiting pickup by a patient. [20]
Unlike commercial drug manufacturers, compounding pharmacies aren't required to report adverse events associated with compounded drugs; the FDA learns of them through voluntary reporting, the media, and other sources. However, according to their records, since 1990 there have been more than 200 adverse events involving 71 compounded products, some with devastating repercussions. Three patients died of infections stemming from contaminated compounded solutions that are used to paralyze the heart during open-heart surgery. Two patients at a Washington, D.C., Veterans Affairs hospital were blinded, and several others had their eyesight damaged by a compounded product used in cataract surgery. The contaminated product had been distributed to hospitals and clinics in eight states. In March 2005, FDA issued a nationwide alert concerning a contaminated, compounded magnesium sulfate solution that caused five cases of bacterial infections in a New Jersey hospital. A South Dakota patient treated with the product developed sepsis and died. In August 2006, the FDA warned three compounding centers to stop manufacturing and distributing thousands of doses of compounded, unapproved inhalation drugs nationwide. Inhalation drugs are used to treat diseases including asthma, emphysema, bronchitis, and cystic fibrosis. An FDA spokesperson stated, "These are potentially life-threatening conditions for which numerous FDA-approved drugs are available; compounded inhalation drugs may be distributed to patients in multiple states, and patients and their doctors may not understand that they are receiving compounded products."[21]
In 2007 Sens. Edward Kennedy (D-MA) and Pat Roberts (R-KS) introduced the Safe Drug Compounding Act of 2007 to give the FDA clear powers to regulate compounding pharmacies, with inspections and premarket approval. From 2001 to 2012, the International Academy of Compounding Pharmacists spent $1.1 million on lobbying, including efforts against this bill.[22]
In October 2012 news reports surfaced of an outbreak of fungal meningitis tied to the New England Compounding Center. [23] At that time it was also disclosed that the U.S. and Massachusetts state health regulators were aware in 2002 that steroid treatments from the New England Compounding Center could cause adverse patient reactions.[24] It was further disclosed that in 2001–02, four people died, more than a dozen were injured and hundreds exposed after they received back-pain injections tainted with a common fungus dispensed by two compounding pharmacies in California and South Carolina.[22]
In August 2013 further reports tied to the New England compounding center said that about 750 people were sickened, including 63 deaths, and that infections were linked to more than 17,600 doses of methylprednisolone acetate steroid injections used to treat back and joint pain that were shipped to 23 states. At that time, another incident was reported after at least 15 people at two Texas hospitals developed bacterial infections. All lots of medications dispensed since May 9, 2013, made by Specialty Compounding, LLC of Cedar Park, Texas were recalled. The hospitals reported affected were Corpus Christi Medical Center Bay Area and Corpus Christi Medical Center Doctors Regional. The patients had received intravenous (IV) infusions of calcium gluconate, a drug used to treat calcium deficiencies and too much potassium in the blood. Implicated in these cases is the Rhodococcus bacteria, which can cause symptoms such as fever and pain.[25]
New England Compounding Center incident
In October 2012, an outbreak of fungal meningitis was reported in the United States. The U.S. Centers for Disease Control and Prevention traced the outbreak to contaminated medication used for epidural steroid injections. The medication was packaged and marketed by the New England Compounding Center, a compounding pharmacy in Framingham, Massachusetts. On October 15, the FDA issued a warning that two more drugs, a steroid and a product used during heart surgery, may also have been contaminated. The investigation also includes fungal infections associated with injections in a peripheral joint space, such as a knee, shoulder or ankle.[26]
Criticism of compounding misuse and proposed regulatory changes
The FDA and others say that some larger compounding pharmacies are acting like drug manufacturers and yet circumventing FDA regulations under the banner of compounding. Compounding pharmacies are regulated not by FDA but by state agencies, whose regulations are not as strict. Drugs from compounding pharmacies can be much cheaper, and can alleviate shortages, but as noted can pose greater risk of contamination due in part to the lack of FDA oversight. Compounding pharmacies have been regulated by laws that were developed when they solely made custom prescriptions for individual patients, but the FDA has sought additional authority to regulate what they term "non-traditional" compounders" who in essence are more like "miniature drug companies" than true pharmacies. Such "non-traditional" compounders behave like manufacturers in various ways – such as by having sales teams that market non-personalized drug products or production capability to doctors, and by making drugs that are essentially the same as commercially-available mass-produced drug products, and most importantly by pre-making large batches of a given drug product in anticipation of additional same prescriptions but before actually receiving them (the latter being directly the opposite of patient-specific tailoring).[1][27]
An FDA spokesperson states, "The methods of these companies seem far more consistent with those of drug manufacturers than with those of retail pharmacies. Some firms make large amounts of compounded drugs that are copies or near copies of FDA-approved, commercially available drugs. Other firms sell to physicians and patients with whom they have only a remote professional relationship."[21] The head of the FDA has recently requested the following authority from Congress:
"Nontraditional compounding should, because of the higher risk presented, be subject to a greater degree of oversight. Sterile products produced in advance of or without a prescription and shipped interstate should be subject to the highest level of controls, established by FDA and appropriate to the activity, similar to cGMP standards applicable to conventional drug manufacturers. In addition, FDA believes that with noted exceptions, certain products are not appropriate for compounding under any circumstances. These products would include: 1) what are essentially copies of FDA-approved drugs, absent a shortage justification based on the drug appearing on FDA’s shortage list; and 2) complex dosage forms such as extended release products; transdermal patches; liposomal products; most biologics; and other products as designated by FDA. Producing complex dosage forms would require an approved application and compliance with cGMP standards, along with other requirements applicable to manufactured drug products."[28] This statement also went on to advocate certain auditing and testing powers, record-keeping and reporting obligations, etc. While the first part (regarding a lack of prior prescription) is indeed consistent with limiting compounding to its traditional domain of customization, it would however be unprecedented for the FDA to regulate truly individualized drug products solely on the basis of their formulation's "complexity" (although Congress could preempt the states traditional role in this regard). At the same time, this position statement does suggest perhaps some willingness by the FDA to embrace the occasional "non-traditional compounding" of copies of FDA-approved drug products – albeit with greater regulation – in cases of specified shortages.
Various ideas have been proposed to strengthen federal US regulation in this area, including new laws making it easier to identify misuse or misnomered-use[29] and/or stricter enforcement of the longstanding distinction between compounding versus manufacturing.[30][31] Also, some US states have taken initiatives to strengthen their own oversight of compounding pharmacies.[32]
Regulation in Australia
In Australia there is no regulatory board that governs how and where a pharmacist compounds medications. It is very important for consumers to choose their Australian compounding pharmacies carefully as they are all self-regulated. The only guidelines that need to be followed are by the pharmacies' governing body – The Pharmacy Board – where the only regulation is that a compounded product be prepared on an individual basis (not manufactured) and they follow the Professional Practice Standards – Section 10.[33] Since compounding has grown in popularity, the highest quality compounding chemists are self regulated. Compounding Chemists Australia,[34] is a website devoted to ensuring they only list reputable compounding chemists. It is not uncommon to find compounding being performed in the pharmacy's back room near the kitchen sink, however, this is not illegal. Sterile compounding and non-sterile compounding have different requirements. For sterile compounding, the use of a laminar flow hood or vertical flow hood must be used. In non-sterile compounding, including most topical compounded medications, a hood is not required and does not adversely effect potency or quality of the final product.
See also
- Apothecary — the ancestral practitioner of compounding, and his shop
- Bioidentical hormone replacement therapy — Compounding is involved in the surrounding controversy
- Professional Compounding Centers of America
- New England Compounding Center meningitis outbreak
References
- ^ a b Grady, Denise; Pollack, Andrew and Tavernise, Sabrina (2012-10-07). Scant Oversight of Drug Maker in Fatal Meningitis Outbreak. New York Times.
- ^ Information taken from the abstract of Hadzović, S (1997). "[Pharmacy and the great contribution of Arab-Islamic science to its development] (Article in Croatian)". Medicinski arhiv. 51 (1–2): 47–50. ISSN 0350-199X. PMID 9324574.
- ^ Kaf al-Ghazal, Sharif (2004). "The valuable contributions of Al-Razi (Rhazes) in the history of pharmacy during the middle ages". Journal of the International Society for the History of Islamic Medicine. 3: 3–9 [8].
- ^ a b "International Academy of Compounding Pharmacists: Definition of Compounding". Retrieved July 18, 2010.
- ^ "ArmourThyroid". Retrieved July 17, 2010.
- ^ "Options for thyroid treatment | Stop The Thyroid Madness". Retrieved July 17, 2010.
- ^ "www.fda.gov". Retrieved July 18, 2010.
- ^ Boothby LA, Doering PL (2008). "Bioidentical hormone therapy: a panacea that lacks supportive evidence". Curr. Opin. Obstet. Gynecol. 20 (4): 400–7. doi:10.1097/GCO.0b013e3283081ae9. PMID 18660693.
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- ^ http://onlinelibrary.wiley.com/doi/10.1002/jps.23165/abstract
- ^ "International Academy of Compounding Pharmacists: Frequently Asked Questions". Retrieved July 18, 2010.
- ^ Kotz, Deborah (2012-10-11) How risky are compounding pharmacies?. Boston.com. Retrieved on 2013-05-13.
- ^ Barrett, Paul M. (2012-11-14) America's Shadow Pharmacies. Businessweek. Retrieved on 2013-05-13.
- ^ Thompson v. Western States Medical Center (535 U.S. 357, 2002). law.cornell.edu
- ^ "Medical Center Pharmacy v. Mukasey". Fda.gov. Retrieved February 5, 2012.
- ^ "Importation of Active Pharmaceutical Ingredients (APIs) Requirements CPG 460.200 Pharmacy Compounding Compliance Policy Guides Manual (Tab M)" (PDF). Retrieved February 5, 2012.
- ^ a b "American Society of Health-Systems Pharmacists: Statement on the Use of Medications for Unlabeled Use". Retrieved April 4, 2012.
- ^ a b Bogdanich, Walt and Tavernise, Sabrina (2012-10-22). U.S. Concern Over Compounders Predates Outbreak of Meningitis. New York Times.
- ^ a b c The Special Risks of Pharmacy Compounding. Fda.gov (2012-12-03). Retrieved on 2012-12-19.
- ^ a b Pharmacies Fought Controls; Industry at the Focus of Meningitis Outbreak Beat Back More Federal Oversight, By THOMAS M. BURTON, JAMES V. GRIMALDI and TIMOTHY W. MARTIN, Wall Street Journal, October 14, 2012 Cite error: The named reference "WSJ2" was defined multiple times with different content (see the help page).
- ^ Meningitis outbreak toll: 119 cases, 11 deaths. Usatoday.com (2012-10-09). Retrieved on 2012-12-19.
- ^ Morgan, David (October 22, 2012). "Health officials knew of problem steroids in 2002: U.S. House panel". Reuters.
- ^ http://www.cbsnews.com/8301-204_162-57598110/texas-compounding-pharmacy-recalls-drugs-after-15-infections/
- ^ Cdc – Hai. Cdc.gov. Retrieved on 2012-12-19.
- ^ Martin, T. W.; Burton, T. M. and Dooren, J. C. (October 9, 2012). "Outbreak Spurs Calls for New Controls". The Wall Street Journal. The Wall Street Journal. Retrieved October 9, 2012.
{{cite web}}
: CS1 maint: multiple names: authors list (link) - ^ A Continuing Investigation into the Fungal Meningitis Outbreak and Whether It Could Have Been Prevented. Statement of Margraret A. Hamburg, M.D., Commissioner of Food and Drugs, April 16, 2013.
- ^ Pikesville man joins push for drug oversight reform after meningitis outbreak – Baltimore Sun. Articles.baltimoresun.com (2012-11-14). Retrieved on 2013-05-13.
- ^ Morin, Monte. (2013-04-16) FDA chief vows to get 'aggressive' with compounding pharmacies. latimes.com. Retrieved on 2013-05-13.
- ^ Michigan Journal of Law Reform » Compounding Reform: Reconsidering the Draft Safe Drug Compounding Act of 2007 in Light of the Ongoing Fungal Meningitis Outbreak. Mjlr.org (2013-03-17). Retrieved on 2013-05-13.
- ^ Proposed Legislative Reforms Addressing Compounded Drugs. cidreview.cidmcorp.com
- ^ "Professional Practice Standards VERSION 4 2010" (PDF). Retrieved February 5, 2012.
- ^ "Compounding Chemists Australia". Compoundingchemists.com.au. Retrieved February 5, 2012.