Eltoprazine
Eltoprazine is a piperazine-derivative and so-called serenic, or antiaggressive drug, used as a research chemical in scientific studies.[1] It is closely related to several other piperazines, including fluprazine, flesinoxan, and TFMPP, as well as more distantly to the azapirones such as buspirone. Eltoprazine acts as an agonist at the 5-HT1A and 5-HT1B receptors, and as an antagonist at the 5-HT2C receptor.[2] Its serenic properties may actually be mediated by anxiogenesis.[3]
References
- ^ Olivier B, Mos J, Rasmussen D. (1990). "Behavioural pharmacology of the serenic, eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 31–83. PMID 2091890.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Schipper J, Tulp MT, Sijbesma H. (1990). "Neurochemical profile of eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 85–114. PMID 1982626.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Rodgers RJ, Cole JC, Cobain MR, Daly P, Doran PJ, Eells JR, Wallis P. (1992). "Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP". Behav Pharmacol. 3 (6): 621–634. PMID 11224163.
{{cite journal}}: CS1 maint: multiple names: authors list (link)