CGS-21680
2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethyl-carboxamidoadenosine or C23H29N7O6·HCl (CGS21680) is a specific adenosine A2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.
The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in repiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.
It is currently manufactured by Sigma Aldrich and Tocris with the exclusive permission of Novartis Pharma AG, U.S. Patent 4,968,697.
External Links
- Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol. 100 (1): 91–97. PMID 16141383.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Xie S, Shafer G, Wilson CG, Martin HB (2006). "In vitro adenosine detection with a diamond-based sensor". Dia Rel Mater. 15 (2–3): 225–228. doi:10.1016/j.diamond.2005.08.018.
{{cite journal}}: CS1 maint: multiple names: authors list (link)