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==Synthesis==
==Synthesis==
{{See also|Vinyl iodide functional group}}

Vinyl chloride is produced by dehydrochlorination of 1,2-dichloroethane.<ref name=Ullmann/>
Vinyl chloride is produced by dehydrochlorination of 1,2-dichloroethane.<ref name=Ullmann/>


Due to their high utility, many approaches to vinyl halides have been developed, such as:
A large number of reactions to form vinyl halides, which includes the reaction of vinyl [[organometallic]] species with halogens, and the [[Takai olefination|Takai]] and [[Wittig reaction|Wittig olefination]] reactions. [[Olefin metathesis]] has also been shown to offer a distinct synthesis approach to access vinyl halides efficiently and stereoselectively.<ref>{{Cite journal|last = Koh|first = Ming Joo|last2 = Nguyen|first2 = Thach T.|last3 = Zhang|first3 = Hanmo|last4 = Schrock|first4 = Richard R.|last5 = Hoveyda|first5 = Amir H.|title = Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis|journal = Nature|volume = 531|issue = 7595|pages = 459–465|doi = 10.1038/nature17396|pmid=27008965|pmc=4858352|bibcode = 2016Natur.531..459K|year = 2016}}</ref>

* reactions of vinyl [[organometallic]] species with halogens
[[File:Carbometalation.png|400px|Carbometalation]]

* [[Takai olefination]]
[[File:TakaiMechanism.svg|600px|Takai Olefination]]

* Stork-Zhao olefination - a modification of the [[Wittig reaction]]
[[File:Stork-Zhao Olefination.jpg|Stork-Zhao Olefination]]

* [[Olefin metathesis]]<ref>{{Cite journal|last = Koh|first = Ming Joo|last2 = Nguyen|first2 = Thach T.|last3 = Zhang|first3 = Hanmo|last4 = Schrock|first4 = Richard R.|last5 = Hoveyda|first5 = Amir H.|title = Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis|journal = Nature|volume = 531|issue = 7595|pages = 459–465|doi = 10.1038/nature17396|pmid=27008965|pmc=4858352|bibcode = 2016Natur.531..459K|year = 2016}}</ref>


==Reactions==
==Reactions==

Revision as of 20:58, 29 July 2020

General structure of a vinyl halide, where X is a halogen and R is a radical group

In organic chemistry, a vinyl halide is a compound with the formula CH2=CHX (X = halide). The term vinyl is often used to describe any alkenyl group. For this reason, alkenyl halides with the formula RCH=CHX are sometimes called vinyl halides. From the perspective of applications, the dominant member of this class of compounds is vinyl chloride, which is produced on the scale of millions of tons per year as a precursor to polyvinyl chloride.[1] Polyvinyl fluoride is another commercial product. Related compounds include vinylidene chloride and vinylidene fluoride.

Synthesis

Vinyl chloride is produced by dehydrochlorination of 1,2-dichloroethane.[1]

Due to their high utility, many approaches to vinyl halides have been developed, such as:

Carbometalation

Takai Olefination

Stork-Zhao Olefination

Reactions

Vinyl bromide and related alkenyl halides form the Grignard reagent and related organolithium reagents. Alkenyl halides undergo base elimination to give the corresponding alkyne. Most important is their use in cross-coupling reactions (e.g. Suzuki-Miyaura coupling, Stille coupling, Heck coupling, etc.).

See also

References

  1. ^ a b E.-L. Dreher; T. R. Torkelson; K. K. Beutel (2011). "Chlorethanes and Chloroethylenes". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.o06_o01. ISBN 978-3527306732.
  2. ^ Koh, Ming Joo; Nguyen, Thach T.; Zhang, Hanmo; Schrock, Richard R.; Hoveyda, Amir H. (2016). "Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis". Nature. 531 (7595): 459–465. Bibcode:2016Natur.531..459K. doi:10.1038/nature17396. PMC 4858352. PMID 27008965.

[1]


  1. ^ Nguyen, Thach T.; Koh, Ming Joo; Shen, Xiao; Romiti, Filippo; Schrock, Richard R.; Hoveyda, Amir H. (2016-04-29). "Kinetically controlled E-selective catalytic olefin metathesis". Science. 352 (6285): 569–575. Bibcode:2016Sci...352..569N. doi:10.1126/science.aaf4622. PMC 5748243. PMID 27126041.