Perindopril/indapamide: Difference between revisions
No edit summary |
Names Tags: Mobile edit Mobile web edit |
||
Line 14: | Line 14: | ||
| class2 = [[Thiazide-like diuretic]] |
| class2 = [[Thiazide-like diuretic]] |
||
<!--Clinical data--> |
<!--Clinical data--> |
||
| tradename = Preterax, Noliprel |
| tradename = Preterax, Noliprel, Coversyl Plus |
||
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
||
| pregnancy_US = <!-- A / B / C / D / X --> |
| pregnancy_US = <!-- A / B / C / D / X --> |
||
Line 36: | Line 36: | ||
}} |
}} |
||
'''Perindopril/indapamide''' (marketed as '''Preterax''' and '''Noliprel''') is a combination medication which contains [[perindopril]] (an [[ACE inhibitor]]) and [[indapamide]] (a [[thiazide]]-like [[diuretic]]) both of which are used for the treatment of [[essential hypertension]] (high blood pressure).<ref name="BeeversLip2014">{{cite book|author1=D. Gareth Beevers|author2=Gregory Y. H. Lip|author3=Eoin T. O'Brien|title=ABC of Hypertension|url=https://books.google.com/books?id=HwShBQAAQBAJ&pg=PA83|date=26 November 2014|publisher=Wiley|isbn=978-1-118-59256-4|pages=83–}}</ref> |
'''Perindopril/indapamide''' (marketed as '''Preterax''', '''Coversyl Plus''' and '''Noliprel''') is a combination medication which contains [[perindopril]] (an [[ACE inhibitor]]) and [[indapamide]] (a [[thiazide]]-like [[diuretic]]) both of which are used for the treatment of [[essential hypertension]] (high blood pressure).<ref name="BeeversLip2014">{{cite book|author1=D. Gareth Beevers|author2=Gregory Y. H. Lip|author3=Eoin T. O'Brien|title=ABC of Hypertension|url=https://books.google.com/books?id=HwShBQAAQBAJ&pg=PA83|date=26 November 2014|publisher=Wiley|isbn=978-1-118-59256-4|pages=83–}}</ref> |
||
== Medical uses == |
== Medical uses == |
Revision as of 02:22, 7 August 2019
This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages)
|
Combination of | |
---|---|
Perindopril | ACE inhibitor |
Indapamide | Thiazide-like diuretic |
Clinical data | |
Trade names | Preterax, Noliprel, Coversyl Plus |
Routes of administration | Oral (tablets) |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
(verify) |
Perindopril/indapamide (marketed as Preterax, Coversyl Plus and Noliprel) is a combination medication which contains perindopril (an ACE inhibitor) and indapamide (a thiazide-like diuretic) both of which are used for the treatment of essential hypertension (high blood pressure).[1]
Medical uses
Administration
One tablet daily, preferably to be taken in the morning and before a meal.
Elderly: Normal dosage.
Kidney failure: Creatinine clearance (CrCl) >30 mL/min: no dosage modification. If CrCl <30 mL/min, treatment is contraindicated.
Contraindications
Absolute contraindications to taking perindopril/indapamide include a known allergy to perindopril, indapamide, or sulfonamides; history of Quincke's edema linked to previous ACE inhibitor therapy; end-stage kidney disease; serious liver disease; high levels of potassium in the blood; pregnancy; and lactation.
Relative contraindications to using this medication include combination therapy with lithium, potassium salts, potassium-sparing diuretics, and certain medicines which can cause abnormal heart rhythms.
Side effects
Side effects of perindopril/indapamide may include weakness, dizziness, headache, mood swings and/or sleep disturbances. Additionally, cramps, low blood pressure, allergic reactions, skin rashes, gastrointestinal disorders, dry cough, erectile dysfunctions, dry mouth, and a risk of dehydration in the elderly and in people who have congestive heart failure.
Immunosuppressed patients. Hemodialysis: risk of anaphylactoid reaction during hemodialysis with polyacrylonitrile membranes. Liver impairment.
Caution is recommended when prescribing perindopril/indapamide to people with electrolyte disorders, diabetes, gout, low blood pressure, or strict sodium-free diets, heart or kidney failure, atherosclerosis, renal artery stenosis, and in elderly people.
Pharmacology
Using a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension.
Drug interactions
Not recommended: combinations with lithium, potassium-sparing diuretics, potassium (salts), antiarrhythmic drugs which can cause torsades de pointes, anesthetic drugs, cytostatics or immunosuppressive agents.
References
- ^ D. Gareth Beevers; Gregory Y. H. Lip; Eoin T. O'Brien (26 November 2014). ABC of Hypertension. Wiley. pp. 83–. ISBN 978-1-118-59256-4.