Methanandamide: Difference between revisions
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'''Methanandamide''' ('''AM-356''') is a [[Organic compound#Synthetic compounds|synthetic]]ally created stable [[Chiral (chemistry)|chiral]] [[Structural analog|analog]] of [[anandamide]].<ref>{{cite journal |pmid= 8021930 |year= 1994 |last= Abadji |first= V|title= (R)-methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability |volume= 37 |issue= 12 |pages= 1889–93 |journal= Journal of Medicinal Chemistry |doi=10.1021/jm00038a020|display-authors=etal}}</ref> Its effects have been observed to act on the [[cannabinoid receptor]]s (specifically on [[Cannabinoid receptor type 1|CB<sub>1</sub>]] receptors, which are part of the [[central nervous system]]) found in different organisms such as mammals, fish, and certain invertebrates (e.g. ''[[Hydra (genus)|Hydra]]''). |
'''Methanandamide''' ('''AM-356''') is a [[Organic compound#Synthetic compounds|synthetic]]ally created stable [[Chiral (chemistry)|chiral]] [[Structural analog|analog]] of [[anandamide]].<ref>{{cite journal |pmid= 8021930 |year= 1994 |last= Abadji |first= V.|title= (''R'')-methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability |volume= 37 |issue= 12 |pages= 1889–93 |journal= Journal of Medicinal Chemistry |doi=10.1021/jm00038a020|display-authors=etal}}</ref> Its effects have been observed to act on the [[cannabinoid receptor]]s (specifically on [[Cannabinoid receptor type 1|CB<sub>1</sub>]] receptors, which are part of the [[central nervous system]]) found in different organisms such as mammals, fish, and certain invertebrates (e.g. ''[[Hydra (genus)|Hydra]]''). |
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==References== |
==References== |
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Revision as of 10:06, 2 August 2016
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| Names | |
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| IUPAC name
(5Z,8Z,11Z,14Z)-N-[(1R)-2-hydroxy-1-methylethyl]icosa-5,8,11,14-tetraenamide
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| Other names
AM-356; Arachidonyl-1'-hydroxy-2'-propylamide
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| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
| ChemSpider | |
PubChem CID
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| Properties | |
| C23H39NO2 | |
| Molar mass | 361.570 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Methanandamide (AM-356) is a synthetically created stable chiral analog of anandamide.[1] Its effects have been observed to act on the cannabinoid receptors (specifically on CB1 receptors, which are part of the central nervous system) found in different organisms such as mammals, fish, and certain invertebrates (e.g. Hydra).
References
- ^ Abadji, V.; et al. (1994). "(R)-methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability". Journal of Medicinal Chemistry. 37 (12): 1889–93. doi:10.1021/jm00038a020. PMID 8021930.
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