Hemoglobin D-Punjab: Difference between revisions
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Hemoglobin D-Punjab is one of the sub-variants of Hemoglobin D, a variant of [[hemoglobin]] found in human blood. It is so named because of its higher prevalence in the [[Punjab]] region of [[India]] and [[Pakistan]]. |
'''Hemoglobin D-Punjab''' is one of the sub-variants of Hemoglobin D, a variant of [[hemoglobin]] found in human blood. It is so named because of its higher prevalence in the [[Punjab]] region of [[India]] and [[Pakistan]]. It is also the most frequent abnormal hemoglobin variant in [[Xinjiang Uyghur Autonomous Region]] of [[China]]. Studies indicate that Hemoglobin D-Punjab accounts for over 55% of the total [[hemoglobin variants]] there. |
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Hemoglobin D-Punjab was first discovered in the early 1950s in a mixed British and American family of Indian origin from the [[Los Angeles]] area; hence it is also sometimes called “D Los Angeles”. Hemoglobin D is the 4th most common hemoglobin variant. It developed as a response to the selective pressures of malaria in these regions of Asia.{{citation needed|date=December 2013}} |
Hemoglobin D-Punjab was first discovered in the early 1950s in a mixed British and American family of Indian origin from the [[Los Angeles]] area; hence it is also sometimes called “D Los Angeles”. Hemoglobin D is the 4th most common hemoglobin variant. It developed as a response to the selective pressures of malaria in these regions of Asia.{{citation needed|date=December 2013}} |
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==Symptoms of Hemoglobin D Disease== |
==Symptoms of Hemoglobin D Disease== |
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Hemoglobin D Disease can cause mild hemolytic [[anemia]] and mild to moderate [[splenomegaly]]. The anemia usually occurs in the first few months of life, as fetal hemoglobin decreases and hemoglobin D increases.{{citation needed|date=December 2013}} |
Hemoglobin D Disease can cause mild hemolytic [[anemia]] and mild to moderate [[splenomegaly]]. The anemia usually occurs in the first few months of life, as fetal hemoglobin decreases and hemoglobin D increases.{{citation needed|date=December 2013}} |
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==See also== |
==See also== |
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* [[Hemoglobin S|Hb S]] |
* [[Hemoglobin S|Hb S]] |
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Revision as of 18:02, 13 February 2015
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Hemoglobin D-Punjab is one of the sub-variants of Hemoglobin D, a variant of hemoglobin found in human blood. It is so named because of its higher prevalence in the Punjab region of India and Pakistan. It is also the most frequent abnormal hemoglobin variant in Xinjiang Uyghur Autonomous Region of China. Studies indicate that Hemoglobin D-Punjab accounts for over 55% of the total hemoglobin variants there.
Hemoglobin D-Punjab was first discovered in the early 1950s in a mixed British and American family of Indian origin from the Los Angeles area; hence it is also sometimes called “D Los Angeles”. Hemoglobin D is the 4th most common hemoglobin variant. It developed as a response to the selective pressures of malaria in these regions of Asia.[citation needed]
Linkage with Hemoglobin D Trait
Among the seven known types of Hemoglobin D, only Hemoglobin D Punjab can cause a serious hemoglobin disorder. While Hemoglobin D can be detected without a DNA test, one is needed to ascertain that a person who carries Hemoglobin D carries hemoglobin D-Punjab.[citation needed]
When a person has both Hemoglobin A and Hemoglobin D, one is said to have the Hemoglobin D Trait. Offspring of such individuals have increased risk of having Hemoglobin D Disease, Hemoglobin SD disease or Beta-thalassemia Disease.[citation needed]
Symptoms of Hemoglobin D Disease
Hemoglobin D Disease can cause mild hemolytic anemia and mild to moderate splenomegaly. The anemia usually occurs in the first few months of life, as fetal hemoglobin decreases and hemoglobin D increases.[citation needed]
See also
References
1. Tyagi S, Marwaha N, Parmar V, Basu S. Sickle cell hemoglobin-D Punjab disease (Compound Heterozygous state). Ind J Hematol Blood Transf 2000;18:31-2. 2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715661/ 3. http://www.idph.state.il.us/HealthWellness/fs/hemoglobin_d.htm 4. http://health.utah.gov/newbornscreening/Disorders/HB/Hb_D_Disease_DD/FactSheet_Provider_HbDD_En.pdf 5. www.chime.ucl.ac.uk/APoGI/data/rtf/hb/carriers/b/dp/carbook.rtf