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Mange is also a nickname for the name Magnus.

Mange /ˈmeɪndʒ/ is a class of skin diseases caused by parasitic mites.^[1] Since mites also infect plants, birds, and reptiles, the term "mange" or "the mange", suggesting poor condition of the hairy coat due to the infection, is sometimes reserved only for pathological mite-infestation of nonhuman mammals. Thus, mange includes mite-associated skin disease in domestic animals (cats and dogs), in livestock (such as sheep scab), and in wild animals (for example, coyotes, cougars, and bears).^[2]^[3] Since mites belong to the arachnid subclass Acari (also called Acarina), another term for mite infestation is acariasis.

Parasitic mites that cause mange in mammals embed themselves either in skin or hair follicles in the animal, depending upon their genus. Sarcoptes spp. burrow into skin, while Demodex spp. live in follicles.

In humans, these two types of mite infections, which would otherwise be known as "mange" in furry mammals, are instead known, respectively, as scabies and demodicosis. However, the mites that cause these diseases in humans are closely related to those that cause the mange in other mammals.

Types of mange

Demodectic mange

Also called demodicosis or the red mange, demodectic mange is caused by a sensitivity to and overpopulation of Demodex canis if the animal's immune system is unable to keep the mites under control. The two types of demodectic mange are localized and generalized. Localized consists of four spots or less. Most dogs are immune to demodectic mange, but dogs with compromised immune systems and the elderly are at a higher risk. It is not contagious to humans.

Arthur Stanley Hirst, a noted authority on Acari states "In typical cases of this complaint the mites are found in enormous numbers, but Friedrich Gmeiner and also Albert E. Mettam have shown that D. canis is not the actual cause of follicular mange, which is due to a bacterium Staphylococcus epidermidis or some allied form. The mite plays an important part in the disease, however, by preparing the ground for the invasion of the bacterium by dilating the follicles and sweat-glands, and possibly also carries and introduces the germ. Whilst the Acari remain in the follicles or sweat-glands some of the bacteria may penetrate more deeply and be conveyed from one point to another by the blood-stream." - "Studies on Acari No. 1. The Genus Demodex, Owen" ^[4]

A type of demodectic infection in humans is known, but is less commonly symptomatic. See Demodex folliculorum.

Sarcoptic mange

Sarcoptic mange, also known as canine scabies, is a highly contagious infestation of Sarcoptes scabiei canis, a burrowing mite. The canine sarcoptic mite can also infest cats, pigs, horses, sheep, and various other species. The human analog of burrowing mite infection, due to a closely related species, is called scabies (the "seven year itch").

All these burrowing mites are in the family Sarcoptidae. They dig into and through the skin, causing intense itching from an allergic reaction to the mite, and crusting that can quickly become infected. Hair loss and crusting frequently appear first on elbows and ears. Skin damage can occur from the dog's intense scratching and biting. Secondary skin infection is also common. Dogs with chronic sarcoptic mange are often in poor condition, and in both animals and humans, immune suppression from starvation or any other disease causes this type of mange to develop into a highly crusted form in which the burden of mites is far higher than in healthy specimens.

Treatment

Dogs affected with demodectic mange do not need to be isolated from other dogs. Demodectic mange is generally only contagious from mother to pup during suckling; it is not contagious after weaning. Many puppies will grow out of demodectic mange as their immune systems mature, but it can recur if the immune system is compromised, such as after steroid treatment or other immunocompromising illness.

In cases of sarcoptic mange, affected dogs need to be isolated from other dogs and their bedding, and places they have occupied must be thoroughly cleaned. Other dogs in contact with a diagnosed case should be evaluated and treated. A number of parasitical treatments are useful in treating canine scabies. Sulfurated lime (a mixture of calcium polysulfides) rinses applied weekly or biweekly are effective (the concentrated form for use on plants as a fungicide must be diluted 1:16 or 1:32 for use on animal skin).

Selamectin is licensed for treatment in dogs by veterinary prescription in several countries; it is applied as a dose directly to the skin, once per month (the drug does not wash off). A related and older drug ivermectin is also effective and can be given by mouth for two to four weekly treatments or until two negative skin scrapings are achieved. Oral ivermectim is not safe to use on some collie-like herding dogs, however, due to possible homozygous MDR1 (P-glycoprotein) mutations that increase its toxicity by allowing it into the brain. Ivermectin injections are also effective and given in either weekly or every two weeks in one to four doses, although the same MDR1 dog restrictions apply.

Topical 0.01% ivermectin in oil (Acarexx) has been reported to be effective in humans, and all mite infections in many types of animals (especially in ear mite infections where the animal cannot lick the treated area), and is so poorly absorbed that systemic toxicity is less likely in these sites. Nevertheless, topical ivermectin has not been well enough tested to be approved for this use in dogs, and is theoretically much more dangerous in zones where the animal can potentially lick the treated area. Selamectin applied to the skin (topically) has some of the same theoretical problems in collies and MDR1 dogs as ivermectim, but it has nevertheless been approved for use for all dogs provided that the animal can be observed for 8 hours after the first monthly treatment.

Similar treatments, including monthly selamectin, are used in cats with mange. A notable difference for cat treatment is that permethrin, which can be used in both dogs and humans with this condition, cannot be used in cats. The differences in cat and dog treatment are not due to differences in the mites so much as the mitocides which are poisonous to the host.

For treatment of sarcoptic infection in humans, see scabies. For demodetic infection in humans, which is not as severe as it is in animals with thicker coats (such as dogs), see Demodex folliculorum.

Diagnosis

Veterinarians usually attempt diagnosis with skin scrapings from multiple areas, which are then examined under a microscope for mites. Sarcoptes mites, because they may be present in relatively low numbers, and because they are often removed by dogs chewing at themselves, may be difficult to demonstrate. As a result, diagnosis in sarcoptic mange is often based on symptoms rather than actual confirmation of the presence of mites. A common and simple way of determining if a dog has mange is if it displays what is called a "pedal-pinna reflex", which is when the dog moves one of its hind legs in a scratching motion as the ear is being manipulated and scratched gently by the examiner; because the mites proliferate on the ear margins in nearly all cases at some point, this method works over 95% of the time.^[5] It is helpful in cases where all symptoms of mange are present but no mites are observed with a microscope. The test is also positive in animals with ear mites, an ear canal infection caused by a different but closely related mite (treatment is often the same). In some countries, an available serologic test may be useful in diagnosis.

References

^ "Mange – Definition and More from the Free Merriam-Webster Dictionary". Merriam-webster.com. 2010-08-13. Retrieved 2010-11-14.
^ "mange" at Dorland's Medical Dictionary
^ [1] Severe mite-caused mange in wild bears
^ http://ia600303.us.archive.org/32/items/studiesonacarino00brituoft/studiesonacarino00brituoft.pdf
^ "Sarcoptic Mites and Mange: Also Known As Scabies in Dogs and Cats". Thepetcenter.com. Retrieved 2010-11-14.

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 [[Selamectin]] is licensed for treatment in dogs by veterinary prescription in several countries; it is applied as a dose directly to the skin, once per month (the drug does not wash off). A related and older drug [[ivermectin]] is also effective and can be given by mouth for two to four weekly treatments or until two negative skin scrapings are achieved. Oral ivermectim is not safe to use on some collie-like [[herding dog]]s, however, due to possible homozygous [[MDR1]] ([[P-glycoprotein]]) mutations that increase its toxicity by allowing it into the brain. Ivermectin injections are also effective and given in either weekly or every two weeks in one to four doses, although the same MDR1 dog restrictions apply.
-Topical 0.01% ivermectin in oil ([[Acarexx]]) has been reported to be effective in humans, and all mite infections in many types of animals (especially in [[ear mite]] infections where the animal cannot lick the treated area), and is so poorly absorbed that systemic toxicity is less likely in these sites. Nevertheless, topical ivermectin has not been well enough tested to be approved for this use in dogs, and is theoretically much more dangerous in zones where the animal can potentially lick the treated area. Selamectin applied to the skin (i.e., topically) has some of the same theoretical problems in collies and MDR1 dogs as ivermectim, but it has nevertheless been approved for use for all dogs provided that the animal can be observed for 8 hours after the first monthly treatment.
+Topical 0.01% ivermectin in oil ([[Acarexx]]) has been reported to be effective in humans, and all mite infections in many types of animals (especially in [[ear mite]] infections where the animal cannot lick the treated area), and is so poorly absorbed that systemic toxicity is less likely in these sites. Nevertheless, topical ivermectin has not been well enough tested to be approved for this use in dogs, and is theoretically much more dangerous in zones where the animal can potentially lick the treated area. Selamectin applied to the skin (topically) has some of the same theoretical problems in collies and MDR1 dogs as ivermectim, but it has nevertheless been approved for use for all dogs provided that the animal can be observed for 8 hours after the first monthly treatment.
 Similar treatments, including monthly selamectin, are used in cats with mange. A notable difference for cat treatment is that [[permethrin]], which can be used in both dogs and humans with this condition, cannot be used in cats. The differences in cat and dog treatment are not due to differences in the mites so much as the mitocides which are poisonous to the host.